Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions

This study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were as...

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Autores: Iriondo De Hond, Amaia, Rios, Maria Belen, Herrera, Teresa, Rodríguez Bertos, Antonio Manuel, Nuñez, Fernando, San Andrés Larrea, Manuel Ignacio, Sánchez-Fortún Rodríguez, Sebastián, del Castillo, Maria Dolores
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8054
Acceso en línea:https://hdl.handle.net/20.500.14352/8054
Access Level:acceso abierto
Palabra clave:antioxidant
coffee silverskin
food safety
novel food
nutrition
short-chain fatty acids
Alimentación
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spelling Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological FunctionsIriondo De Hond, AmaiaRios, Maria BelenHerrera, TeresaRodríguez Bertos, Antonio ManuelNuñez, FernandoSan Andrés Larrea, Manuel IgnacioSánchez-Fortún Rodríguez, Sebastiándel Castillo, Maria Doloresantioxidantcoffee silverskinfood safetynovel foodnutritionshort-chain fatty acidsAlimentaciónThis study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were assessed. Proteins, amino acids, fat, fatty acids, fiber, simple sugars and micronutrients were analyzed. For the first time, toxicological and physiological effects were evaluated in vivo by a repeated-dose study in healthy Wistar rats. Hormone secretion, antioxidant (enzymatic and no-enzymatic) and anti-inflammatory biomarkers, and dietary fiber fermentability of CSE (analysis of SCFAs in feces) were studied in biological samples. This unique research confirms the feasibility of CSE as a human dietary supplement with several nutrition claims: “source of proteins (16%), potassium, magnesium, calcium and vitamin C, low in fat (0.44%) and high in fiber (22%)”. This is the first report demonstrating that its oral administration (1 g/kg) for 28 days is innocuous. Hormone secretion, antioxidant or anti-inflammatory biomarkers were not affected in heathy animals. Total SCFAs derived from CSE fiber fermentation were significantly higher (p < 0.05) in male treated rats compared to male control rats. All the new information pinpoints CSE as a natural, sustainable and safe food ingredient containing fermentable fiber able to produce SCFAs with beneficial effects on gut microbiota.MDPIUniversidad Complutense de Madrid20192019-11-0720192019-11-07journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8054reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/80542026-06-02T12:44:21Z
dc.title.none.fl_str_mv Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
title Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
spellingShingle Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
Iriondo De Hond, Amaia
antioxidant
coffee silverskin
food safety
novel food
nutrition
short-chain fatty acids
Alimentación
title_short Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
title_full Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
title_fullStr Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
title_full_unstemmed Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
title_sort Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
dc.creator.none.fl_str_mv Iriondo De Hond, Amaia
Rios, Maria Belen
Herrera, Teresa
Rodríguez Bertos, Antonio Manuel
Nuñez, Fernando
San Andrés Larrea, Manuel Ignacio
Sánchez-Fortún Rodríguez, Sebastián
del Castillo, Maria Dolores
author Iriondo De Hond, Amaia
author_facet Iriondo De Hond, Amaia
Rios, Maria Belen
Herrera, Teresa
Rodríguez Bertos, Antonio Manuel
Nuñez, Fernando
San Andrés Larrea, Manuel Ignacio
Sánchez-Fortún Rodríguez, Sebastián
del Castillo, Maria Dolores
author_role author
author2 Rios, Maria Belen
Herrera, Teresa
Rodríguez Bertos, Antonio Manuel
Nuñez, Fernando
San Andrés Larrea, Manuel Ignacio
Sánchez-Fortún Rodríguez, Sebastián
del Castillo, Maria Dolores
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv antioxidant
coffee silverskin
food safety
novel food
nutrition
short-chain fatty acids
Alimentación
topic antioxidant
coffee silverskin
food safety
novel food
nutrition
short-chain fatty acids
Alimentación
description This study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were assessed. Proteins, amino acids, fat, fatty acids, fiber, simple sugars and micronutrients were analyzed. For the first time, toxicological and physiological effects were evaluated in vivo by a repeated-dose study in healthy Wistar rats. Hormone secretion, antioxidant (enzymatic and no-enzymatic) and anti-inflammatory biomarkers, and dietary fiber fermentability of CSE (analysis of SCFAs in feces) were studied in biological samples. This unique research confirms the feasibility of CSE as a human dietary supplement with several nutrition claims: “source of proteins (16%), potassium, magnesium, calcium and vitamin C, low in fat (0.44%) and high in fiber (22%)”. This is the first report demonstrating that its oral administration (1 g/kg) for 28 days is innocuous. Hormone secretion, antioxidant or anti-inflammatory biomarkers were not affected in heathy animals. Total SCFAs derived from CSE fiber fermentation were significantly higher (p < 0.05) in male treated rats compared to male control rats. All the new information pinpoints CSE as a natural, sustainable and safe food ingredient containing fermentable fiber able to produce SCFAs with beneficial effects on gut microbiota.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-11-07
2019
2019-11-07
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8054
url https://hdl.handle.net/20.500.14352/8054
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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