Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing

A decline in mitochondrial function and increased susceptibility to oxidative stress is a hallmark of ageing. Exercise endogenously generates reactive oxygen species (ROS) in skeletal muscle and promotes mitochondrial remodelling resulting in improved mitochondrial function. It is unclear how exerci...

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Autores: Xia, Qin, Li, Penglin, Casas-Martínez, José C., Miranda-Vizuete, Antonio, McDermott, Emma, Dockery, Peter, Goljanek-Whysall, Katarzyna, McDonagh, Brian
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/387150
Acceso en línea:http://hdl.handle.net/10261/387150
https://api.elsevier.com/content/abstract/scopus_id/85201859243
Access Level:acceso abierto
Palabra clave:Ageing
C.elegans
DAF-16
Exercise
Mitochondrial ER contact sites
Peroxiredoxin 2
eat-3
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spelling Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageingXia, QinLi, PenglinCasas-Martínez, José C.Miranda-Vizuete, AntonioMcDermott, EmmaDockery, PeterGoljanek-Whysall, KatarzynaMcDonagh, BrianAgeingC.elegansDAF-16ExerciseMitochondrial ER contact sitesPeroxiredoxin 2eat-3A decline in mitochondrial function and increased susceptibility to oxidative stress is a hallmark of ageing. Exercise endogenously generates reactive oxygen species (ROS) in skeletal muscle and promotes mitochondrial remodelling resulting in improved mitochondrial function. It is unclear how exercise induced redox signalling results in alterations in mitochondrial dynamics and morphology.We would like to sincerely thank Elizabeth Veal lab for providing the anti-PRDX-2 antibody and VE1 prdx-2 mutant strain, the Tavernarakis lab for providing the IR2539 mitophagy reporter strain and the facilities and scientific and technical assistance of the Anatomy Imaging and Microscopy Facility at the University of Galway (https://imaging.universityofgalway.ie/imaging/) for electron microscopy work. QX (202006370047) and PL (202206370063) studentships are funded by the Chinese Scholarship Council (CSC), JCCM studentship is funded by the College of Nursing Medicine and Health Sciences, University of Galway.Peer reviewedElsevier BVChina Scholarship CouncilUniversity of GalwayMiranda-Vizuete, Antonio [0000-0002-6856-5396]McDonagh, Brian [0000-0003-2534-4427]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/387150https://api.elsevier.com/content/abstract/scopus_id/85201859243reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésXia, Qin; Li, Penglin; Casas-Martínez, José C.; Miranda-Vizuete, Antonio; McDermott, Emma; Dockery, Peter; Goljanek-Whysall, Katarzyna; McDonagh, Brian; 2024; Peroxiredoxin regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing [Dataset]; Mendeley Data; https://doi.org/10.17632/shysb8dsw3.1https://doi.org/10.1016/j.molmet.2024.102003Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3871502026-05-22T06:33:51Z
dc.title.none.fl_str_mv Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing
title Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing
spellingShingle Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing
Xia, Qin
Ageing
C.elegans
DAF-16
Exercise
Mitochondrial ER contact sites
Peroxiredoxin 2
eat-3
title_short Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing
title_full Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing
title_fullStr Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing
title_full_unstemmed Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing
title_sort Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing
dc.creator.none.fl_str_mv Xia, Qin
Li, Penglin
Casas-Martínez, José C.
Miranda-Vizuete, Antonio
McDermott, Emma
Dockery, Peter
Goljanek-Whysall, Katarzyna
McDonagh, Brian
author Xia, Qin
author_facet Xia, Qin
Li, Penglin
Casas-Martínez, José C.
Miranda-Vizuete, Antonio
McDermott, Emma
Dockery, Peter
Goljanek-Whysall, Katarzyna
McDonagh, Brian
author_role author
author2 Li, Penglin
Casas-Martínez, José C.
Miranda-Vizuete, Antonio
McDermott, Emma
Dockery, Peter
Goljanek-Whysall, Katarzyna
McDonagh, Brian
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv China Scholarship Council
University of Galway
Miranda-Vizuete, Antonio [0000-0002-6856-5396]
McDonagh, Brian [0000-0003-2534-4427]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ageing
C.elegans
DAF-16
Exercise
Mitochondrial ER contact sites
Peroxiredoxin 2
eat-3
topic Ageing
C.elegans
DAF-16
Exercise
Mitochondrial ER contact sites
Peroxiredoxin 2
eat-3
description A decline in mitochondrial function and increased susceptibility to oxidative stress is a hallmark of ageing. Exercise endogenously generates reactive oxygen species (ROS) in skeletal muscle and promotes mitochondrial remodelling resulting in improved mitochondrial function. It is unclear how exercise induced redox signalling results in alterations in mitochondrial dynamics and morphology.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/387150
https://api.elsevier.com/content/abstract/scopus_id/85201859243
url http://hdl.handle.net/10261/387150
https://api.elsevier.com/content/abstract/scopus_id/85201859243
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Xia, Qin; Li, Penglin; Casas-Martínez, José C.; Miranda-Vizuete, Antonio; McDermott, Emma; Dockery, Peter; Goljanek-Whysall, Katarzyna; McDonagh, Brian; 2024; Peroxiredoxin regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing [Dataset]; Mendeley Data; https://doi.org/10.17632/shysb8dsw3.1
https://doi.org/10.1016/j.molmet.2024.102003
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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