White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

van Velzen, LS; Kelly, S; Isaev, D; Aleman, A; Aftanas, LI; Bauer, J; Baune, BT; Brak, IV; Carballedo, A; Connolly, CG; Couvy-Duchesne, B; Cullen, KR; Danilenko, KV; Dannlowski, U; Enneking, V; Filimonova, E; Foerster, K; Frodl, T; Gotlib, IH; Groenewold, NA; Grotegerd, D; Harris, MA; Hatton, SN; Hawkins, EL; Hickie, IB; Ho, TC; Jansen, A; Kircher, T; Klimes-Dougan, B; Kochunov, P; Krug, A; Lagopoulos, J; Lee, R; Lett, TA; Li, M; MacMaster, FP; Martin, NG; McIntosh, AM; McLellan, Q; Meinert, S; Nenadic, I; Osipov, E; Penninx, BWJH; Portella, MJ; Repple, J; Roos, A; Sacchet, MD; Saemann, PG; Schnell, K; Shen, XY; Sim, K; Stein, DJ; van Tol, MJ; Tomyshev, AS; Tozzi, L; Veer, IM; Vermeiren, R; Vives-Gilabert, Y; Walter, H; Walter, M; van der Wee, NJA; van der Werff, SJA; Schreiner, MW; Whalley, HC; Wright, MJ; Yang, TT; Zhu, A; Veltman, DJ; Thompson, PM; Jahanshad, N; Schmaal, L

White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we e...

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Autores:	van Velzen, LS, Kelly, S, Isaev, D, Aleman, A, Aftanas, LI, Bauer, J, Baune, BT, Brak, IV, Carballedo, A, Connolly, CG, Couvy-Duchesne, B, Cullen, KR, Danilenko, KV, Dannlowski, U, Enneking, V, Filimonova, E, Foerster, K, Frodl, T, Gotlib, IH, Groenewold, NA, Grotegerd, D, Harris, MA, Hatton, SN, Hawkins, EL, Hickie, IB, Ho, TC, Jansen, A, Kircher, T, Klimes-Dougan, B, Kochunov, P, Krug, A, Lagopoulos, J, Lee, R, Lett, TA, Li, M, MacMaster, FP, Martin, NG, McIntosh, AM, McLellan, Q, Meinert, S, Nenadic, I, Osipov, E, Penninx, BWJH, Portella, MJ, Repple, J, Roos, A, Sacchet, MD, Saemann, PG, Schnell, K, Shen, XY, Sim, K, Stein, DJ, van Tol, MJ, Tomyshev, AS, Tozzi, L, Veer, IM, Vermeiren, R, Vives-Gilabert, Y, Walter, H, Walter, M, van der Wee, NJA, van der Werff, SJA, Schreiner, MW, Whalley, HC, Wright, MJ, Yang, TT, Zhu, A, Veltman, DJ, Thompson, PM, Jahanshad, N, Schmaal, L
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2020
País:	España
Institución:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p1825
Acceso en línea:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1825 http://ddd.uab.cat/record/226603
Access Level:	acceso abierto

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spelling	White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working groupvan Velzen, LSKelly, SIsaev, DAleman, AAftanas, LIBauer, JBaune, BTBrak, IVCarballedo, AConnolly, CGCouvy-Duchesne, BCullen, KRDanilenko, KVDannlowski, UEnneking, VFilimonova, EFoerster, KFrodl, TGotlib, IHGroenewold, NAGrotegerd, DHarris, MAHatton, SNHawkins, ELHickie, IBHo, TCJansen, AKircher, TKlimes-Dougan, BKochunov, PKrug, ALagopoulos, JLee, RLett, TALi, MMacMaster, FPMartin, NGMcIntosh, AMMcLellan, QMeinert, SNenadic, IOsipov, EPenninx, BWJHPortella, MJRepple, JRoos, ASacchet, MDSaemann, PGSchnell, KShen, XYSim, KStein, DJvan Tol, MJTomyshev, ASTozzi, LVeer, IMVermeiren, RVives-Gilabert, YWalter, HWalter, Mvan der Wee, NJAvan der Werff, SJASchreiner, MWWhalley, HCWright, MJYang, TTZhu, AVeltman, DJThompson, PMJahanshad, NSchmaal, LAlterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12-88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen'sdbetween 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen'sdbetween 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD.SPRINGERNATURE2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1825http://ddd.uab.cat/record/226603MOLECULAR PSYCHIATRYISSN: 13594184ISSNe: 14765578reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p18252026-06-14T12:41:47Z
dc.title.none.fl_str_mv	White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
title	White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
spellingShingle	White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group van Velzen, LS
title_short	White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
title_full	White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
title_fullStr	White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
title_full_unstemmed	White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
title_sort	White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
dc.creator.none.fl_str_mv	van Velzen, LS Kelly, S Isaev, D Aleman, A Aftanas, LI Bauer, J Baune, BT Brak, IV Carballedo, A Connolly, CG Couvy-Duchesne, B Cullen, KR Danilenko, KV Dannlowski, U Enneking, V Filimonova, E Foerster, K Frodl, T Gotlib, IH Groenewold, NA Grotegerd, D Harris, MA Hatton, SN Hawkins, EL Hickie, IB Ho, TC Jansen, A Kircher, T Klimes-Dougan, B Kochunov, P Krug, A Lagopoulos, J Lee, R Lett, TA Li, M MacMaster, FP Martin, NG McIntosh, AM McLellan, Q Meinert, S Nenadic, I Osipov, E Penninx, BWJH Portella, MJ Repple, J Roos, A Sacchet, MD Saemann, PG Schnell, K Shen, XY Sim, K Stein, DJ van Tol, MJ Tomyshev, AS Tozzi, L Veer, IM Vermeiren, R Vives-Gilabert, Y Walter, H Walter, M van der Wee, NJA van der Werff, SJA Schreiner, MW Whalley, HC Wright, MJ Yang, TT Zhu, A Veltman, DJ Thompson, PM Jahanshad, N Schmaal, L
author	van Velzen, LS
author_facet	van Velzen, LS Kelly, S Isaev, D Aleman, A Aftanas, LI Bauer, J Baune, BT Brak, IV Carballedo, A Connolly, CG Couvy-Duchesne, B Cullen, KR Danilenko, KV Dannlowski, U Enneking, V Filimonova, E Foerster, K Frodl, T Gotlib, IH Groenewold, NA Grotegerd, D Harris, MA Hatton, SN Hawkins, EL Hickie, IB Ho, TC Jansen, A Kircher, T Klimes-Dougan, B Kochunov, P Krug, A Lagopoulos, J Lee, R Lett, TA Li, M MacMaster, FP Martin, NG McIntosh, AM McLellan, Q Meinert, S Nenadic, I Osipov, E Penninx, BWJH Portella, MJ Repple, J Roos, A Sacchet, MD Saemann, PG Schnell, K Shen, XY Sim, K Stein, DJ van Tol, MJ Tomyshev, AS Tozzi, L Veer, IM Vermeiren, R Vives-Gilabert, Y Walter, H Walter, M van der Wee, NJA van der Werff, SJA Schreiner, MW Whalley, HC Wright, MJ Yang, TT Zhu, A Veltman, DJ Thompson, PM Jahanshad, N Schmaal, L
author_role	author
author2	Kelly, S Isaev, D Aleman, A Aftanas, LI Bauer, J Baune, BT Brak, IV Carballedo, A Connolly, CG Couvy-Duchesne, B Cullen, KR Danilenko, KV Dannlowski, U Enneking, V Filimonova, E Foerster, K Frodl, T Gotlib, IH Groenewold, NA Grotegerd, D Harris, MA Hatton, SN Hawkins, EL Hickie, IB Ho, TC Jansen, A Kircher, T Klimes-Dougan, B Kochunov, P Krug, A Lagopoulos, J Lee, R Lett, TA Li, M MacMaster, FP Martin, NG McIntosh, AM McLellan, Q Meinert, S Nenadic, I Osipov, E Penninx, BWJH Portella, MJ Repple, J Roos, A Sacchet, MD Saemann, PG Schnell, K Shen, XY Sim, K Stein, DJ van Tol, MJ Tomyshev, AS Tozzi, L Veer, IM Vermeiren, R Vives-Gilabert, Y Walter, H Walter, M van der Wee, NJA van der Werff, SJA Schreiner, MW Whalley, HC Wright, MJ Yang, TT Zhu, A Veltman, DJ Thompson, PM Jahanshad, N Schmaal, L
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
description	Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12-88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen'sdbetween 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen'sdbetween 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD.
publishDate	2020
dc.date.none.fl_str_mv	2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1825 http://ddd.uab.cat/record/226603
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1825 http://ddd.uab.cat/record/226603
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	SPRINGERNATURE
publisher.none.fl_str_mv	SPRINGERNATURE
dc.source.none.fl_str_mv	MOLECULAR PSYCHIATRY ISSN: 13594184 ISSNe: 14765578 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

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