Pleural and pericardial effusion associated with Bartonella henselae infection in a feline patient

A 7-year-old female spayed domestic shorthair cat was presented to our hospital with a 2-day history of anorexia, dyspnoea and lethargy. Blood tests revealed mild anaemia (packed cell volume [PCV] 22.4%) and the biochemistry panel was unremarkable. Thoracic radiographs and echocardiography showed th...

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Detalles Bibliográficos
Autores: Torrano Guillamón, Ana, Juarez Sarrión, Casandra, Álvarez-Fernández, Alejandra|||0000-0002-1906-0180, Solano Gallego, Laia|||0000-0001-8479-4896, González Villajos, Carlos, Arenas Bermejo, Carolina, Castro López, Jorge
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:317368
Acceso en línea:https://ddd.uab.cat/record/317368
https://dx.doi.org/urn:doi:10.1177/20551169251313617
Access Level:acceso abierto
Palabra clave:Bartonella henselae
Pleural effusion
Pericardial effusion
Fever
Descripción
Sumario:A 7-year-old female spayed domestic shorthair cat was presented to our hospital with a 2-day history of anorexia, dyspnoea and lethargy. Blood tests revealed mild anaemia (packed cell volume [PCV] 22.4%) and the biochemistry panel was unremarkable. Thoracic radiographs and echocardiography showed the presence of pericardial effusion with cardiac tamponade as well as pleural effusion. During the initial attempt at pericardiocentesis, a small sample was obtained, sufficient only for fluid analysis and cytology. Subsequently, the pericardial effusion immediately resolved, presumably owing to the drainage of pericardial fluid into the pleural space. Thoracocentesis was then performed, yielding 50 ml of fluid. The analysis of the fluid was consistent with a protein-rich transudate associated with macrophagic-neutrophilic inflammation in both sampled areas. PCR was positive for Bartonella henselae in the pleural/pericardial fluid pool and peripheral blood. Bacterial culture was negative and feline coronavirus real-time PCR was negative. The patient was treated with marbofloxacin 5 mg/kg PO q24h for 5 weeks. No clinical signs were reported at this time; however, blood B henselae PCR remained positive. Treatment was changed to doxycycline at 5 mg/kg PO q12h for 6 weeks. The cat remained subclinical throughout the treatment, and a blood PCR after 6 weeks yielded negative results. To the best of the authors' knowledge, the present clinical findings related to B henselae infection in a cat without concurrent heart failure have not been previously documented. This clinical case highlights the need to include Bartonella species as a differential diagnosis in cats with protein-rich transudate effusions associated with neutrophilic-macrophagic inflammation and fever.