Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation

Brain-derived neurotrophic factor (BDNF) and leptin are essential in neurodevelopment and central regulation of feeding and energy balance. We studied the metabolic imprinting effects of physiological leptin supplementation during suckling in the brain of 5-week-old mouse pups. Leptin-treated animal...

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Autores: Rodriguez, Ana María, Asnani-Kishnani, Madhu, Yau Qiu, Zhi Xin, Galmés, Sebastià, Palou, Andreu
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/25249
Acceso en línea:https://hdl.handle.net/20.500.13003/25249
Access Level:acceso abierto
Palabra clave:BDNF
Energy balance
Feeding behaviour
Hypothalamus
Leptin
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spelling Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulationRodriguez, Ana MaríaAsnani-Kishnani, MadhuYau Qiu, Zhi XinGalmés, SebastiàPalou, AndreuBDNFEnergy balanceFeeding behaviourHypothalamusLeptinBrain-derived neurotrophic factor (BDNF) and leptin are essential in neurodevelopment and central regulation of feeding and energy balance. We studied the metabolic imprinting effects of physiological leptin supplementation during suckling in the brain of 5-week-old mouse pups. Leptin-treated animals showed lower cumulative food intake and increased energy efficiency, which was related to higher lean mass. Among different brain areas, hypothalamic expression of Bdnf and upstream transcription control-related genes, such as Ppargc1a and Fndc5, was increased by leptin supplementation, especially in females. This was accompanied by higher expression of energy balance key genes (such as Prkaa2 and Cpt1c) and insulin/leptin signalling pathways, primarily in females, also with lower levels of total/phosphorylated AMPK, ACC or STAT3, mainly in males. In leptin-treated females, the exon IV Bdnf promoter showed increased methylation at a specific CpG site. Leptin supplementation during suckling can sex-dependently imprint hypothalamic gene expression, regulating the Ppargc1a/Fndc5/Bdnf pathway and related genes involved in energy balance, associated with a leaner phenotype, with a higher positive impact in females.Stoneham, MA, USA : Butterworths, c1990-20252025-06-0720252025-06-07research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/25249reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/252492026-06-22T12:44:07Z
dc.title.none.fl_str_mv Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation
title Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation
spellingShingle Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation
Rodriguez, Ana María
BDNF
Energy balance
Feeding behaviour
Hypothalamus
Leptin
title_short Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation
title_full Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation
title_fullStr Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation
title_full_unstemmed Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation
title_sort Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation
dc.creator.none.fl_str_mv Rodriguez, Ana María
Asnani-Kishnani, Madhu
Yau Qiu, Zhi Xin
Galmés, Sebastià
Palou, Andreu
author Rodriguez, Ana María
author_facet Rodriguez, Ana María
Asnani-Kishnani, Madhu
Yau Qiu, Zhi Xin
Galmés, Sebastià
Palou, Andreu
author_role author
author2 Asnani-Kishnani, Madhu
Yau Qiu, Zhi Xin
Galmés, Sebastià
Palou, Andreu
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv BDNF
Energy balance
Feeding behaviour
Hypothalamus
Leptin
topic BDNF
Energy balance
Feeding behaviour
Hypothalamus
Leptin
description Brain-derived neurotrophic factor (BDNF) and leptin are essential in neurodevelopment and central regulation of feeding and energy balance. We studied the metabolic imprinting effects of physiological leptin supplementation during suckling in the brain of 5-week-old mouse pups. Leptin-treated animals showed lower cumulative food intake and increased energy efficiency, which was related to higher lean mass. Among different brain areas, hypothalamic expression of Bdnf and upstream transcription control-related genes, such as Ppargc1a and Fndc5, was increased by leptin supplementation, especially in females. This was accompanied by higher expression of energy balance key genes (such as Prkaa2 and Cpt1c) and insulin/leptin signalling pathways, primarily in females, also with lower levels of total/phosphorylated AMPK, ACC or STAT3, mainly in males. In leptin-treated females, the exon IV Bdnf promoter showed increased methylation at a specific CpG site. Leptin supplementation during suckling can sex-dependently imprint hypothalamic gene expression, regulating the Ppargc1a/Fndc5/Bdnf pathway and related genes involved in energy balance, associated with a leaner phenotype, with a higher positive impact in females.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-06-07
2025
2025-06-07
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/25249
url https://hdl.handle.net/20.500.13003/25249
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Stoneham, MA, USA : Butterworths, c1990-
publisher.none.fl_str_mv Stoneham, MA, USA : Butterworths, c1990-
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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