Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study

Purpose The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological pr...

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Autores: Gómez-Acebo I, Dierssen-Sotos T, Palazuelos-Calderón C, Pérez-Gómez B, Amiano P, Guevara M, Molina AJ, Domingo L, Fernández-Ortiz M, Moreno V, Alguacil J, Fernández-Tardón G, Ibáñez J, Marcos-Gragera R, Diaz-Santos M, Alonso MH, Alonso-Molero J, Castaño-Vinyals G, Palomo AG, Ardanaz E, Molinuevo A, Aragonés N, Kogevinas M, Pollán M, Llorca J
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p7388
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/7388
Access Level:acceso abierto
Palavra-chave:Cohort
Epidemiology
Breast cancer
Relative survival
MCC-spain
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spelling Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain studyGómez-Acebo IDierssen-Sotos TPalazuelos-Calderón CPérez-Gómez BAmiano PGuevara MMolina AJDomingo LFernández-Ortiz MMoreno VAlguacil JFernández-Tardón GIbáñez JMarcos-Gragera RDiaz-Santos MAlonso MHAlonso-Molero JCastaño-Vinyals GPalomo AGArdanaz EMolinuevo AAragonés NKogevinas MPollán MLlorca JCohortEpidemiologyBreast cancerRelative survivalMCC-spainPurpose The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increasedSPRINGER2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/7388BREAST CANCER RESEARCH AND TREATMENTISSN: 01676806ISSNe: 15737217reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p73882026-06-11T12:45:17Z
dc.title.none.fl_str_mv Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
spellingShingle Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
Gómez-Acebo I
Cohort
Epidemiology
Breast cancer
Relative survival
MCC-spain
title_short Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_full Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_fullStr Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_full_unstemmed Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_sort Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
dc.creator.none.fl_str_mv Gómez-Acebo I
Dierssen-Sotos T
Palazuelos-Calderón C
Pérez-Gómez B
Amiano P
Guevara M
Molina AJ
Domingo L
Fernández-Ortiz M
Moreno V
Alguacil J
Fernández-Tardón G
Ibáñez J
Marcos-Gragera R
Diaz-Santos M
Alonso MH
Alonso-Molero J
Castaño-Vinyals G
Palomo AG
Ardanaz E
Molinuevo A
Aragonés N
Kogevinas M
Pollán M
Llorca J
author Gómez-Acebo I
author_facet Gómez-Acebo I
Dierssen-Sotos T
Palazuelos-Calderón C
Pérez-Gómez B
Amiano P
Guevara M
Molina AJ
Domingo L
Fernández-Ortiz M
Moreno V
Alguacil J
Fernández-Tardón G
Ibáñez J
Marcos-Gragera R
Diaz-Santos M
Alonso MH
Alonso-Molero J
Castaño-Vinyals G
Palomo AG
Ardanaz E
Molinuevo A
Aragonés N
Kogevinas M
Pollán M
Llorca J
author_role author
author2 Dierssen-Sotos T
Palazuelos-Calderón C
Pérez-Gómez B
Amiano P
Guevara M
Molina AJ
Domingo L
Fernández-Ortiz M
Moreno V
Alguacil J
Fernández-Tardón G
Ibáñez J
Marcos-Gragera R
Diaz-Santos M
Alonso MH
Alonso-Molero J
Castaño-Vinyals G
Palomo AG
Ardanaz E
Molinuevo A
Aragonés N
Kogevinas M
Pollán M
Llorca J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cohort
Epidemiology
Breast cancer
Relative survival
MCC-spain
topic Cohort
Epidemiology
Breast cancer
Relative survival
MCC-spain
description Purpose The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/7388
url https://fisabio.portalinvestigacion.com/publicaciones/7388
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER
publisher.none.fl_str_mv SPRINGER
dc.source.none.fl_str_mv BREAST CANCER RESEARCH AND TREATMENT
ISSN: 01676806
ISSNe: 15737217
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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