Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)

Objective To explore the separate and joint associations of childhood adversities and 5-HTTLPR polymorphism as risk factors for substance use disorders among adults. Design Retrospective case-control study. Setting Cases from the substance unit and controls from a representative sample of the adult...

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Autores: Navarro Mateu, Fernando, Quesada, Mari Paz, Escámez, Teresa, Alcaraz, María José, Seiquer de la Peña, Catherine, Salmerón, Diego, Huerta, José María, Vilagut Saiz, Gemma, 1975-, Chirlaque, María Dolores, Navarro, Carmen, Husky, Mathilde M., Kessler, Ronald C., Alonso Caballero, Jordi, Martínez, Salvador
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/42379
Acesso em linha:http://hdl.handle.net/10230/42379
http://dx.doi.org/10.1136/bmjopen-2019-030328
Access Level:acceso abierto
Palavra-chave:Case-control study
Childhood adversities 5-HTTLPR polymorphism
Risk factors
Substance use disorders
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spelling Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)Navarro Mateu, FernandoQuesada, Mari PazEscámez, TeresaAlcaraz, María JoséSeiquer de la Peña, CatherineSalmerón, DiegoHuerta, José MaríaVilagut Saiz, Gemma, 1975-Chirlaque, María DoloresNavarro, CarmenHusky, Mathilde M.Kessler, Ronald C.Alonso Caballero, JordiMartínez, SalvadorCase-control studyChildhood adversities 5-HTTLPR polymorphismRisk factorsSubstance use disordersObjective To explore the separate and joint associations of childhood adversities and 5-HTTLPR polymorphism as risk factors for substance use disorders among adults. Design Retrospective case-control study. Setting Cases from the substance unit and controls from a representative sample of the adult general population in the metropolitan area of Murcia (Spain). Participants Cases were defined as outpatients 18 years old or older currently in the treatment for alcohol, opioids or cocaine use disorders in the clinical unit. Controls were randomly selected among individuals without substance use disorders who participated in the Psychiatric Enquiry to General Population in Southeast Spain-Murcia (PEGASUS-Murcia) project, a cross-sectional study of a representative sample of the adult general population. In all, 142 cases and 531 controls were interviewed and a subsample of 114 cases (80.3%) and 329 controls (62%) provided a biological sample. Exposure A history of 12 childhood adversities, lifetime mental disorders and sociodemographic variables was assessed with the Composite International Diagnostic Interview (CIDI)version 3.0). Buccal swabs were obtained to genotype the 5-HTTLPR polymorphism with the biallelic and the triallelic classification. Main outcome and measure Multivariable logistic regression models were performed to estimate adjusted ORs and 95% CI. Results Childhood adversities were associated with an elevated risk of substance use disorders (OR=5.77, 95% CI 3.46 to 9.61). Homozygotes for the short allele of the 5-HTTLPR polymorphism also showed the elevated risk of substance use disorders for the biallelic and triallelic classification: (1.97 (1.10 to 3.55) and 2.01 (1.11 to 3.64), respectively). No evidence for gene × environment interactions was found. Conclusions Childhood adversities and the 5-HTTLPR polymorphism are involved in the aetiology of substance use disorders though findings exploring the existence of a gene–environment interaction were inconclusive.BMJ Publishing Group201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/42379http://dx.doi.org/10.1136/bmjopen-2019-030328reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBMJ Open. 2019; 9(9):e030328© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/423792026-06-12T07:21:37Z
dc.title.none.fl_str_mv Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
title Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
spellingShingle Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
Navarro Mateu, Fernando
Case-control study
Childhood adversities 5-HTTLPR polymorphism
Risk factors
Substance use disorders
title_short Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
title_full Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
title_fullStr Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
title_full_unstemmed Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
title_sort Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
dc.creator.none.fl_str_mv Navarro Mateu, Fernando
Quesada, Mari Paz
Escámez, Teresa
Alcaraz, María José
Seiquer de la Peña, Catherine
Salmerón, Diego
Huerta, José María
Vilagut Saiz, Gemma, 1975-
Chirlaque, María Dolores
Navarro, Carmen
Husky, Mathilde M.
Kessler, Ronald C.
Alonso Caballero, Jordi
Martínez, Salvador
author Navarro Mateu, Fernando
author_facet Navarro Mateu, Fernando
Quesada, Mari Paz
Escámez, Teresa
Alcaraz, María José
Seiquer de la Peña, Catherine
Salmerón, Diego
Huerta, José María
Vilagut Saiz, Gemma, 1975-
Chirlaque, María Dolores
Navarro, Carmen
Husky, Mathilde M.
Kessler, Ronald C.
Alonso Caballero, Jordi
Martínez, Salvador
author_role author
author2 Quesada, Mari Paz
Escámez, Teresa
Alcaraz, María José
Seiquer de la Peña, Catherine
Salmerón, Diego
Huerta, José María
Vilagut Saiz, Gemma, 1975-
Chirlaque, María Dolores
Navarro, Carmen
Husky, Mathilde M.
Kessler, Ronald C.
Alonso Caballero, Jordi
Martínez, Salvador
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Case-control study
Childhood adversities 5-HTTLPR polymorphism
Risk factors
Substance use disorders
topic Case-control study
Childhood adversities 5-HTTLPR polymorphism
Risk factors
Substance use disorders
description Objective To explore the separate and joint associations of childhood adversities and 5-HTTLPR polymorphism as risk factors for substance use disorders among adults. Design Retrospective case-control study. Setting Cases from the substance unit and controls from a representative sample of the adult general population in the metropolitan area of Murcia (Spain). Participants Cases were defined as outpatients 18 years old or older currently in the treatment for alcohol, opioids or cocaine use disorders in the clinical unit. Controls were randomly selected among individuals without substance use disorders who participated in the Psychiatric Enquiry to General Population in Southeast Spain-Murcia (PEGASUS-Murcia) project, a cross-sectional study of a representative sample of the adult general population. In all, 142 cases and 531 controls were interviewed and a subsample of 114 cases (80.3%) and 329 controls (62%) provided a biological sample. Exposure A history of 12 childhood adversities, lifetime mental disorders and sociodemographic variables was assessed with the Composite International Diagnostic Interview (CIDI)version 3.0). Buccal swabs were obtained to genotype the 5-HTTLPR polymorphism with the biallelic and the triallelic classification. Main outcome and measure Multivariable logistic regression models were performed to estimate adjusted ORs and 95% CI. Results Childhood adversities were associated with an elevated risk of substance use disorders (OR=5.77, 95% CI 3.46 to 9.61). Homozygotes for the short allele of the 5-HTTLPR polymorphism also showed the elevated risk of substance use disorders for the biallelic and triallelic classification: (1.97 (1.10 to 3.55) and 2.01 (1.11 to 3.64), respectively). No evidence for gene × environment interactions was found. Conclusions Childhood adversities and the 5-HTTLPR polymorphism are involved in the aetiology of substance use disorders though findings exploring the existence of a gene–environment interaction were inconclusive.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/42379
http://dx.doi.org/10.1136/bmjopen-2019-030328
url http://hdl.handle.net/10230/42379
http://dx.doi.org/10.1136/bmjopen-2019-030328
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv BMJ Open. 2019; 9(9):e030328
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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