Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort

COPPADIS Study Group.

Bibliographic Details
Authors: Jesús Maestre, Silvia, Labrador, Miguel Ángel, Adarmes-Gómez, Astrid, Méndel-Del Barrio, C., Martinez-Castrillo, Juan Carlos, Alonso Cánovas, Araceli, Sánchez Alonso, Pilar, Novo Ponte, S., Alonso Losada, María G., López-Ariztegui, Nuria, Segundo Rodríguez, J. C., Morales Casado, M. I., Gastón, Itziar, Lacruz, F., Clavero, Pedro, Kulisevsky, Jaime, Pagonabarraga-Mora, Javier, Pascual-Sedano, Berta, Martínez-Martín, Pablo, Santos-García, Diego, Mir, Pablo
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/236546
Online Access:http://hdl.handle.net/10261/236546
Access Level:Open access
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spelling Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohortJesús Maestre, SilviaLabrador, Miguel ÁngelAdarmes-Gómez, AstridMéndel-Del Barrio, C.Martinez-Castrillo, Juan CarlosAlonso Cánovas, AraceliSánchez Alonso, PilarNovo Ponte, S.Alonso Losada, María G.López-Ariztegui, NuriaSegundo Rodríguez, J. C.Morales Casado, M. I.Gastón, ItziarLacruz, F.Clavero, PedroKulisevsky, JaimePagonabarraga-Mora, JavierPascual-Sedano, BertaMartínez-Martín, PabloSantos-García, DiegoMir, PabloCOPPADIS Study Group.The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.Funding sources: www.curemoselparkinson.org.Springer NatureCuremos el PárkinsonConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/236546reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://doi.org/10.1038/s41598-020-73756-zSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2365462026-05-22T06:33:51Z
dc.title.none.fl_str_mv Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
spellingShingle Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
Jesús Maestre, Silvia
title_short Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title_full Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title_fullStr Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title_full_unstemmed Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
title_sort Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
dc.creator.none.fl_str_mv Jesús Maestre, Silvia
Labrador, Miguel Ángel
Adarmes-Gómez, Astrid
Méndel-Del Barrio, C.
Martinez-Castrillo, Juan Carlos
Alonso Cánovas, Araceli
Sánchez Alonso, Pilar
Novo Ponte, S.
Alonso Losada, María G.
López-Ariztegui, Nuria
Segundo Rodríguez, J. C.
Morales Casado, M. I.
Gastón, Itziar
Lacruz, F.
Clavero, Pedro
Kulisevsky, Jaime
Pagonabarraga-Mora, Javier
Pascual-Sedano, Berta
Martínez-Martín, Pablo
Santos-García, Diego
Mir, Pablo
author Jesús Maestre, Silvia
author_facet Jesús Maestre, Silvia
Labrador, Miguel Ángel
Adarmes-Gómez, Astrid
Méndel-Del Barrio, C.
Martinez-Castrillo, Juan Carlos
Alonso Cánovas, Araceli
Sánchez Alonso, Pilar
Novo Ponte, S.
Alonso Losada, María G.
López-Ariztegui, Nuria
Segundo Rodríguez, J. C.
Morales Casado, M. I.
Gastón, Itziar
Lacruz, F.
Clavero, Pedro
Kulisevsky, Jaime
Pagonabarraga-Mora, Javier
Pascual-Sedano, Berta
Martínez-Martín, Pablo
Santos-García, Diego
Mir, Pablo
author_role author
author2 Labrador, Miguel Ángel
Adarmes-Gómez, Astrid
Méndel-Del Barrio, C.
Martinez-Castrillo, Juan Carlos
Alonso Cánovas, Araceli
Sánchez Alonso, Pilar
Novo Ponte, S.
Alonso Losada, María G.
López-Ariztegui, Nuria
Segundo Rodríguez, J. C.
Morales Casado, M. I.
Gastón, Itziar
Lacruz, F.
Clavero, Pedro
Kulisevsky, Jaime
Pagonabarraga-Mora, Javier
Pascual-Sedano, Berta
Martínez-Martín, Pablo
Santos-García, Diego
Mir, Pablo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Curemos el Párkinson
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description COPPADIS Study Group.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/236546
url http://hdl.handle.net/10261/236546
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://doi.org/10.1038/s41598-020-73756-z
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411718602424320
score 15,812429

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