CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression

[Introduction]: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear...

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Autores: Rodrigues, Cristiana, Laranjeira, Paula, Pinho, Aryane, Silva, Isabel, Silva, Sandra, Coucelo, Margarida, Oliveira, Ana C., Simões, Ana Teresa, Damásio, Inês, Matos Silva, Helena, Urbano, Mafalda, Sarmento-Ribeiro, Ana Bela, Geraldes, Catarina, Domingues, M. Rosário, Almeida, Julia, Criado, Ignacio, Orfao, Alberto, Paiva, Artur
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/370151
Acceso en línea:http://hdl.handle.net/10261/370151
Access Level:acceso abierto
Palabra clave:CD20+ T cells
Chronic lymphocytic leukemia
Monoclonal B lymphocytosis
Immunoglobulin heavy chain variable region
T cell polarization
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
title CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
spellingShingle CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
Rodrigues, Cristiana
CD20+ T cells
Chronic lymphocytic leukemia
Monoclonal B lymphocytosis
Immunoglobulin heavy chain variable region
T cell polarization
title_short CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
title_full CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
title_fullStr CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
title_full_unstemmed CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
title_sort CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
dc.creator.none.fl_str_mv Rodrigues, Cristiana
Laranjeira, Paula
Pinho, Aryane
Silva, Isabel
Silva, Sandra
Coucelo, Margarida
Oliveira, Ana C.
Simões, Ana Teresa
Damásio, Inês
Matos Silva, Helena
Urbano, Mafalda
Sarmento-Ribeiro, Ana Bela
Geraldes, Catarina
Domingues, M. Rosário
Almeida, Julia
Criado, Ignacio
Orfao, Alberto
Paiva, Artur
author Rodrigues, Cristiana
author_facet Rodrigues, Cristiana
Laranjeira, Paula
Pinho, Aryane
Silva, Isabel
Silva, Sandra
Coucelo, Margarida
Oliveira, Ana C.
Simões, Ana Teresa
Damásio, Inês
Matos Silva, Helena
Urbano, Mafalda
Sarmento-Ribeiro, Ana Bela
Geraldes, Catarina
Domingues, M. Rosário
Almeida, Julia
Criado, Ignacio
Orfao, Alberto
Paiva, Artur
author_role author
author2 Laranjeira, Paula
Pinho, Aryane
Silva, Isabel
Silva, Sandra
Coucelo, Margarida
Oliveira, Ana C.
Simões, Ana Teresa
Damásio, Inês
Matos Silva, Helena
Urbano, Mafalda
Sarmento-Ribeiro, Ana Bela
Geraldes, Catarina
Domingues, M. Rosário
Almeida, Julia
Criado, Ignacio
Orfao, Alberto
Paiva, Artur
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Asociación Española Contra el Cáncer
Associazione Italiana per la Ricerca sul Cancro
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv CD20+ T cells
Chronic lymphocytic leukemia
Monoclonal B lymphocytosis
Immunoglobulin heavy chain variable region
T cell polarization
topic CD20+ T cells
Chronic lymphocytic leukemia
Monoclonal B lymphocytosis
Immunoglobulin heavy chain variable region
T cell polarization
description [Introduction]: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/370151
url http://hdl.handle.net/10261/370151
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_1_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s001
Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_2_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s002
Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_3_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s003
Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_4_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s004
Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_5_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s005
https://doi.org/10.3389/fonc.2024.1380648
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progressionRodrigues, CristianaLaranjeira, PaulaPinho, AryaneSilva, IsabelSilva, SandraCoucelo, MargaridaOliveira, Ana C.Simões, Ana TeresaDamásio, InêsMatos Silva, HelenaUrbano, MafaldaSarmento-Ribeiro, Ana BelaGeraldes, CatarinaDomingues, M. RosárioAlmeida, JuliaCriado, IgnacioOrfao, AlbertoPaiva, ArturCD20+ T cellsChronic lymphocytic leukemiaMonoclonal B lymphocytosisImmunoglobulin heavy chain variable regionT cell polarization[Introduction]: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer.[Methods]: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease.[Results and discussion]: CD20+ T cells were more represented within the CD8+ T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vβ 5.1 in CD4+ CD20+ T cells in CLL.This work was supported by the 0639-IDIAL-NET-3-3 grant (INTERREG POCTEP Spain-Portugal) from the European Regional Development Fund, and by the “Early Cancer Research Initiative Network on MBL (ECRINM3)” ACCELERATOR award (CRUK -UK-, Fundación AECC -Spain- and Associazione Italiana per la Ricerca Sul Cancro -Italy).Peer reviewedFrontiers MediaEuropean CommissionAsociación Española Contra el CáncerAssociazione Italiana per la Ricerca sul CancroConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/370151reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésRodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_1_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s001Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_2_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s002Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_3_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s003Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_4_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s004Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana C.; Simões, Ana Teresa; Damásio, Inês; Matos Silva, Helena; Urbano, Mafalda; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Domingues, M. Rosário; Almeida, Julia; Criado, Ignacio; Orfao, Alberto; Paiva, Artur; 2024; Image_5_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]; Frontiers Media; https://doi.org/10.3389/fonc.2024.1380648.s005https://doi.org/10.3389/fonc.2024.1380648Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3701512026-05-22T06:33:51Z
score 15,81155

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