Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease

Background Adults with Down syndrome are at an ultra-high risk of developing early-onset Alzheimer's disease. Episodic memory deficits are one of the earliest signs of the disease, but their association with regional brain atrophy in the population with Down syndrome has not been explored. We a...

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Autores: Benejam, B, Aranha, MR, Videla, L, Padilla, C, Valldeneu, S, Fernandez, S, Altuna, M, Carmona-Iragui, M, Barroeta, I, Iulita, MF, Montal, V, Pegueroles, J, Bejanin, A, Gimenez, S, Gonzalez-Ortiz, S, Videla, S, Bartres-Faz, D, Alcolea, D, Blesa, R, Lleo, A, Fortea, J
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositório:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p13021
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13021
https://ddd.uab.cat/record/275204
Access Level:Acceso aberto
Palavra-chave:Down syndrome
Alzheimer's disease
Dementia
Episodic memory
MRI
Cortical thickness
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spelling Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's diseaseBenejam, BAranha, MRVidela, LPadilla, CValldeneu, SFernandez, SAltuna, MCarmona-Iragui, MBarroeta, IIulita, MFMontal, VPegueroles, JBejanin, AGimenez, SGonzalez-Ortiz, SVidela, SBartres-Faz, DAlcolea, DBlesa, RLleo, AFortea, JDown syndromeAlzheimer's diseaseDementiaEpisodic memoryMRICortical thicknessBackground Adults with Down syndrome are at an ultra-high risk of developing early-onset Alzheimer's disease. Episodic memory deficits are one of the earliest signs of the disease, but their association with regional brain atrophy in the population with Down syndrome has not been explored. We aimed to investigate the neuroanatomical correlates of episodic memory in adults with Down syndrome and symptomatic Alzheimer's disease. Methods Single-center, cross-sectional study. A total of 139 adults with Down syndrome (85 asymptomatic and 54 with symptomatic Alzheimer's disease) were included in the study (mean age 43.6 +/- 10.9 years, 46% female). Episodic memory was assessed using the modified Cued Recall Test. Immediate (trial 1 free immediate recall, trial 3 free immediate recall, total free immediate recall score, and total immediate score) and delayed scores (free delayed recall score and total delayed score) were examined. Cortical thickness from magnetic resonance imaging was determined with surface-based morphometry using the FreeSurfer 6.0 software package. The clusters of reduced cortical thickness were compared between symptomatic and asymptomatic participants to create a cortical atrophy map. Then, the correlation between cortical thickness and the modified Cued Recall Test subscores were separately assessed in symptomatic and asymptomatic subjects, controlling for age, sex, and severity of intellectual disability. Results Compared with asymptomatic participants, those with symptomatic Alzheimer's disease showed a pattern of cortical atrophy in posterior parieto-temporo-occipital cortices. In symptomatic subjects, trial 1 immediate free recall significantly correlated with cortical atrophy in lateral prefrontal regions. Trial 3 free immediate recall and total free immediate recall were associated with the most widespread cortical atrophy. Total immediate score was related to posterior cortical atrophy, including lateral parietal and temporal cortex, posterior cingulate cortex, precuneus, and medial temporal lobe areas. Delayed memory scores were associated with cortical atrophy in temporoparietal and medial temporal lobe regions. No significant relationships were observed between episodic memory measures and cortical atrophy in asymptomatic subjects. Conclusions Different episodic memory measures were associated with cortical atrophy in specific brain regions in adults with Down syndrome and Alzheimer's disease. These results overlap with those described in sporadic Alzheimer's disease and further support the similarities between Down syndrome-associated Alzheimer's disease and that in the general population.BMC2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13021https://ddd.uab.cat/record/275204Alzheimers Research & TherapyISSN: 17589193reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p130212026-06-14T12:41:47Z
dc.title.none.fl_str_mv Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease
title Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease
spellingShingle Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease
Benejam, B
Down syndrome
Alzheimer's disease
Dementia
Episodic memory
MRI
Cortical thickness
title_short Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease
title_full Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease
title_fullStr Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease
title_full_unstemmed Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease
title_sort Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease
dc.creator.none.fl_str_mv Benejam, B
Aranha, MR
Videla, L
Padilla, C
Valldeneu, S
Fernandez, S
Altuna, M
Carmona-Iragui, M
Barroeta, I
Iulita, MF
Montal, V
Pegueroles, J
Bejanin, A
Gimenez, S
Gonzalez-Ortiz, S
Videla, S
Bartres-Faz, D
Alcolea, D
Blesa, R
Lleo, A
Fortea, J
author Benejam, B
author_facet Benejam, B
Aranha, MR
Videla, L
Padilla, C
Valldeneu, S
Fernandez, S
Altuna, M
Carmona-Iragui, M
Barroeta, I
Iulita, MF
Montal, V
Pegueroles, J
Bejanin, A
Gimenez, S
Gonzalez-Ortiz, S
Videla, S
Bartres-Faz, D
Alcolea, D
Blesa, R
Lleo, A
Fortea, J
author_role author
author2 Aranha, MR
Videla, L
Padilla, C
Valldeneu, S
Fernandez, S
Altuna, M
Carmona-Iragui, M
Barroeta, I
Iulita, MF
Montal, V
Pegueroles, J
Bejanin, A
Gimenez, S
Gonzalez-Ortiz, S
Videla, S
Bartres-Faz, D
Alcolea, D
Blesa, R
Lleo, A
Fortea, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Down syndrome
Alzheimer's disease
Dementia
Episodic memory
MRI
Cortical thickness
topic Down syndrome
Alzheimer's disease
Dementia
Episodic memory
MRI
Cortical thickness
description Background Adults with Down syndrome are at an ultra-high risk of developing early-onset Alzheimer's disease. Episodic memory deficits are one of the earliest signs of the disease, but their association with regional brain atrophy in the population with Down syndrome has not been explored. We aimed to investigate the neuroanatomical correlates of episodic memory in adults with Down syndrome and symptomatic Alzheimer's disease. Methods Single-center, cross-sectional study. A total of 139 adults with Down syndrome (85 asymptomatic and 54 with symptomatic Alzheimer's disease) were included in the study (mean age 43.6 +/- 10.9 years, 46% female). Episodic memory was assessed using the modified Cued Recall Test. Immediate (trial 1 free immediate recall, trial 3 free immediate recall, total free immediate recall score, and total immediate score) and delayed scores (free delayed recall score and total delayed score) were examined. Cortical thickness from magnetic resonance imaging was determined with surface-based morphometry using the FreeSurfer 6.0 software package. The clusters of reduced cortical thickness were compared between symptomatic and asymptomatic participants to create a cortical atrophy map. Then, the correlation between cortical thickness and the modified Cued Recall Test subscores were separately assessed in symptomatic and asymptomatic subjects, controlling for age, sex, and severity of intellectual disability. Results Compared with asymptomatic participants, those with symptomatic Alzheimer's disease showed a pattern of cortical atrophy in posterior parieto-temporo-occipital cortices. In symptomatic subjects, trial 1 immediate free recall significantly correlated with cortical atrophy in lateral prefrontal regions. Trial 3 free immediate recall and total free immediate recall were associated with the most widespread cortical atrophy. Total immediate score was related to posterior cortical atrophy, including lateral parietal and temporal cortex, posterior cingulate cortex, precuneus, and medial temporal lobe areas. Delayed memory scores were associated with cortical atrophy in temporoparietal and medial temporal lobe regions. No significant relationships were observed between episodic memory measures and cortical atrophy in asymptomatic subjects. Conclusions Different episodic memory measures were associated with cortical atrophy in specific brain regions in adults with Down syndrome and Alzheimer's disease. These results overlap with those described in sporadic Alzheimer's disease and further support the similarities between Down syndrome-associated Alzheimer's disease and that in the general population.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13021
https://ddd.uab.cat/record/275204
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13021
https://ddd.uab.cat/record/275204
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Alzheimers Research & Therapy
ISSN: 17589193
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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