Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.

OBJECTIVES: To determine the prevalence, characteristics, timing of implementation and prognosis of patients with left bundle branch block (LBBB) and acute heart failure (AHF) treated with cardiac resynchronization therapy (CRT) in a real-life registry. METHODS: We analysed the characteristics of pa...

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Autores: Aguiló O, Trullàs JC, Espinosa B, López-Ayala P, Gil V, López-Grima ML, Herrero-Puente P, Jacob J, López-Díez MP, Garrido JM, Millán J, Aguirre A, Piñera P, Müller CE, Llorens P, Miro Ò
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p17616
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/17616
Access Level:acceso abierto
Palabra clave:bundle-branch block
cardiac resynchronization therapy
heart failure
mortality
id ES_7e19244acf2f10c57ea2b610e48dc8d3
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.Aguiló OTrullàs JCEspinosa BLópez-Ayala PGil VLópez-Grima MLHerrero-Puente PJacob JLópez-Díez MPGarrido JMMillán JAguirre APiñera PMüller CELlorens PMiro Òbundle-branch blockcardiac resynchronization therapyheart failuremortalityOBJECTIVES: To determine the prevalence, characteristics, timing of implementation and prognosis of patients with left bundle branch block (LBBB) and acute heart failure (AHF) treated with cardiac resynchronization therapy (CRT) in a real-life registry. METHODS: We analysed the characteristics of patients with AHF and LBBB at the time of inclusion in the EAHFE (Epidemiology Acute Heart Failure Emergency) cohort to determine the indication for CRT, the timing of implementation and its impact on 10-year all-cause mortality. RESULTS: 729 patients with a median age of 82 years and there was a high burden of comorbidities and functional dependence. The median left-ventricle ejection fraction (LVEF) was 40%. Forty-six (6%) patients were treated with CRT at some point during follow-up, with a median time of delay for CRT implementation of 960 (IQR=1,147 days) and at least 108 more untreated patients fulfilled criteria for CRT. Patients receiving CRT were younger, had different comorbidities, less functional dependence (higher Barthel index) and lower LVEF values. The median follow-up was 5.7 years (95% CI: 5.6-5.8) and CRT was not associated with changes in 10-year mortality (adjusted HR 1.33, 95% CI: 0.72-2.48; p-value 0.4). When compared with untreated patients fulfilling criteria for CRT, very similar results were observed (adjusted HR 1.34, 95% CI: 0.67-2.68). CONCLUSIONS: CRT implementation was delayed and underused in patients with AHF and LBBB. Under these circumstances, CRT is not associated with a reduction in all-cause mortality in the long term.CORPORACION EDITORA MEDICA VALLE2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/17616Colombia MedicaISSN: 16579534ISSNe: 01208322reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Españolinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p176162026-06-11T12:45:17Z
dc.title.none.fl_str_mv Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.
title Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.
spellingShingle Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.
Aguiló O
bundle-branch block
cardiac resynchronization therapy
heart failure
mortality
title_short Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.
title_full Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.
title_fullStr Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.
title_full_unstemmed Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.
title_sort Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.
dc.creator.none.fl_str_mv Aguiló O
Trullàs JC
Espinosa B
López-Ayala P
Gil V
López-Grima ML
Herrero-Puente P
Jacob J
López-Díez MP
Garrido JM
Millán J
Aguirre A
Piñera P
Müller CE
Llorens P
Miro Ò
author Aguiló O
author_facet Aguiló O
Trullàs JC
Espinosa B
López-Ayala P
Gil V
López-Grima ML
Herrero-Puente P
Jacob J
López-Díez MP
Garrido JM
Millán J
Aguirre A
Piñera P
Müller CE
Llorens P
Miro Ò
author_role author
author2 Trullàs JC
Espinosa B
López-Ayala P
Gil V
López-Grima ML
Herrero-Puente P
Jacob J
López-Díez MP
Garrido JM
Millán J
Aguirre A
Piñera P
Müller CE
Llorens P
Miro Ò
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv bundle-branch block
cardiac resynchronization therapy
heart failure
mortality
topic bundle-branch block
cardiac resynchronization therapy
heart failure
mortality
description OBJECTIVES: To determine the prevalence, characteristics, timing of implementation and prognosis of patients with left bundle branch block (LBBB) and acute heart failure (AHF) treated with cardiac resynchronization therapy (CRT) in a real-life registry. METHODS: We analysed the characteristics of patients with AHF and LBBB at the time of inclusion in the EAHFE (Epidemiology Acute Heart Failure Emergency) cohort to determine the indication for CRT, the timing of implementation and its impact on 10-year all-cause mortality. RESULTS: 729 patients with a median age of 82 years and there was a high burden of comorbidities and functional dependence. The median left-ventricle ejection fraction (LVEF) was 40%. Forty-six (6%) patients were treated with CRT at some point during follow-up, with a median time of delay for CRT implementation of 960 (IQR=1,147 days) and at least 108 more untreated patients fulfilled criteria for CRT. Patients receiving CRT were younger, had different comorbidities, less functional dependence (higher Barthel index) and lower LVEF values. The median follow-up was 5.7 years (95% CI: 5.6-5.8) and CRT was not associated with changes in 10-year mortality (adjusted HR 1.33, 95% CI: 0.72-2.48; p-value 0.4). When compared with untreated patients fulfilling criteria for CRT, very similar results were observed (adjusted HR 1.34, 95% CI: 0.67-2.68). CONCLUSIONS: CRT implementation was delayed and underused in patients with AHF and LBBB. Under these circumstances, CRT is not associated with a reduction in all-cause mortality in the long term.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/17616
url https://fisabio.portalinvestigacion.com/publicaciones/17616
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CORPORACION EDITORA MEDICA VALLE
publisher.none.fl_str_mv CORPORACION EDITORA MEDICA VALLE
dc.source.none.fl_str_mv Colombia Medica
ISSN: 16579534
ISSNe: 01208322
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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