Big Pharma, Little Science? A bibliometric perspective on big pharma&apos

There is a widespread perception that pharmaceutical R&D is facing a productivity crisis characterised by stagnation in the numbers of new drug approvals in the face of increasing R&D costs. This study explores pharmaceutical R&D dynamics by examining the publication activiti...

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Detalles Bibliográficos
Autores: Ismael Rafols, Hopkins, M.M., Hoekman, J., Siepel, J., O'Hare, A., Perianes-Rodriguez, A., Nightingale, P.
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/62835
Acceso en línea:https://riunet.upv.es/handle/10251/62835
Access Level:acceso abierto
Palabra clave:Pharmaceuticals
Bibliometrics
Outsourcing
Europe
Globalisation
Research network
Innovation
Collaboration
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spelling Big Pharma, Little Science? A bibliometric perspective on big pharma&aposs R&ampD declineIsmael RafolsHopkins, M.M.Hoekman, J.Siepel, J.O'Hare, A.Perianes-Rodriguez, A.Nightingale, P.PharmaceuticalsBibliometricsOutsourcingEuropeGlobalisationResearch networkInnovationCollaborationThere is a widespread perception that pharmaceutical R&D is facing a productivity crisis characterised by stagnation in the numbers of new drug approvals in the face of increasing R&D costs. This study explores pharmaceutical R&D dynamics by examining the publication activities of all R&D laboratories of the major European and US pharmaceutical firms (Big Pharma) during the period 1995-2009. The empirical findings present an industry in transformation. In the first place, we observe a decline of the total number of publications by large firms. Second, we show a relative increase of their external collaborations suggesting a tendency to outsource, and a diversification of the disciplinary base, in particular towards computation, health services and more clinical approaches. Also evident is a more pronounced decline in publications by both R&D laboratories located in Europe and by firms with European headquarters. Finally, while publications by Big Pharma in emerging economies sharply increase, they remain extremely low compared with those in developed countries. In summary, the trend in this transformation is one of a gradual decrease in internal research efforts and increasing reliance on external research. These empirical insights support the view that Big Pharma are increasingly becoming 'network integrators' rather than the prime locus of drug discovery.We thank Mike O'Neill, Luigi Orsenigo and Sergio Sismondo for comments. Ismael Rafols and Alice O'Hare were funded by the EU FP7 project FRIDA(Grant 225546, http://www.fridaproject.eu) and the US NSF (Award no. 0830207, http://idr.gatech.edu/). Michael Hopkins and Josh Siepel were supported by ESRC grant RES-360-25-0076. Jarno Hoekman has been supported by the Netherlands Organisation for Scientific Research (NWO) under the VIDI programme, number 452-06-005. Antonio Perianes-Rodríguez conducted his research at the University of Sussex as awardee of José Castillejo grant, JC2010-0042, funded by the Spanish Ministry of Education. The findings and observations contained in this paper are those of the authors and do not necessarily reflect the views of the funders.ElsevierEuropean CommissionNational Science Foundation, EEUUEconomic and Social Research Council, Reino UnidoNetherlands Organization for Scientific ResearchMinisterio de EducaciónRepositorio Institucional de la Universitat Politècnica de València Riunet20142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/62835reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengEuropean Commission https://doi.org/10.13039/501100000780 FP7 225546 Fostering Regional Innovation and Development through Anchors and Networks: A Cross Regional Comparison in an Evolving International ContextEconomic and Social Research Council, Reino Unido https://doi.org/10.13039/501100000269 RES-360-25-0076 Mapping the Dynamics of Emergent TechnologiesMinisterio de Educación, Argentina ME JC2010-0042 JC2010-0042Netherlands Organization for Scientific Research https://doi.org/10.13039/501100003246 452.06.005National Science Foundation, China https://doi.org/10.13039/100000001 0830207 TLS- Measuring and Tracking Research Knowledge Integrationopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/628352026-06-13T07:49:27Z
dc.title.none.fl_str_mv Big Pharma, Little Science? A bibliometric perspective on big pharma&apos
s R&amp
D decline
title Big Pharma, Little Science? A bibliometric perspective on big pharma&apos
spellingShingle Big Pharma, Little Science? A bibliometric perspective on big pharma&apos
Ismael Rafols
Pharmaceuticals
Bibliometrics
Outsourcing
Europe
Globalisation
Research network
Innovation
Collaboration
title_short Big Pharma, Little Science? A bibliometric perspective on big pharma&apos
title_full Big Pharma, Little Science? A bibliometric perspective on big pharma&apos
title_fullStr Big Pharma, Little Science? A bibliometric perspective on big pharma&apos
title_full_unstemmed Big Pharma, Little Science? A bibliometric perspective on big pharma&apos
title_sort Big Pharma, Little Science? A bibliometric perspective on big pharma&apos
dc.creator.none.fl_str_mv Ismael Rafols
Hopkins, M.M.
Hoekman, J.
Siepel, J.
O'Hare, A.
Perianes-Rodriguez, A.
Nightingale, P.
author Ismael Rafols
author_facet Ismael Rafols
Hopkins, M.M.
Hoekman, J.
Siepel, J.
O'Hare, A.
Perianes-Rodriguez, A.
Nightingale, P.
author_role author
author2 Hopkins, M.M.
Hoekman, J.
Siepel, J.
O'Hare, A.
Perianes-Rodriguez, A.
Nightingale, P.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
National Science Foundation, EEUU
Economic and Social Research Council, Reino Unido
Netherlands Organization for Scientific Research
Ministerio de Educación
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Pharmaceuticals
Bibliometrics
Outsourcing
Europe
Globalisation
Research network
Innovation
Collaboration
topic Pharmaceuticals
Bibliometrics
Outsourcing
Europe
Globalisation
Research network
Innovation
Collaboration
description There is a widespread perception that pharmaceutical R&D is facing a productivity crisis characterised by stagnation in the numbers of new drug approvals in the face of increasing R&D costs. This study explores pharmaceutical R&D dynamics by examining the publication activities of all R&D laboratories of the major European and US pharmaceutical firms (Big Pharma) during the period 1995-2009. The empirical findings present an industry in transformation. In the first place, we observe a decline of the total number of publications by large firms. Second, we show a relative increase of their external collaborations suggesting a tendency to outsource, and a diversification of the disciplinary base, in particular towards computation, health services and more clinical approaches. Also evident is a more pronounced decline in publications by both R&D laboratories located in Europe and by firms with European headquarters. Finally, while publications by Big Pharma in emerging economies sharply increase, they remain extremely low compared with those in developed countries. In summary, the trend in this transformation is one of a gradual decrease in internal research efforts and increasing reliance on external research. These empirical insights support the view that Big Pharma are increasingly becoming 'network integrators' rather than the prime locus of drug discovery.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/62835
url https://riunet.upv.es/handle/10251/62835
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 FP7 225546 Fostering Regional Innovation and Development through Anchors and Networks: A Cross Regional Comparison in an Evolving International Context
Economic and Social Research Council, Reino Unido https://doi.org/10.13039/501100000269 RES-360-25-0076 Mapping the Dynamics of Emergent Technologies
Ministerio de Educación, Argentina ME JC2010-0042 JC2010-0042
Netherlands Organization for Scientific Research https://doi.org/10.13039/501100003246 452.06.005
National Science Foundation, China https://doi.org/10.13039/100000001 0830207 TLS- Measuring and Tracking Research Knowledge Integration
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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