Screen-printed electrodes for the determination of iridium in drugs

Among the impurities that must be controlled in drugs and pharmaceuticals, metal ions are considered. These metal impurities appear in those products because of their use as catalysts. Although Pharmacopeias recommend ICP based methods for their determination, the use of electroanalytical techniques...

Descripción completa

Detalles Bibliográficos
Autores: Zaguirre, Marc, Ariño Blasco, Cristina, Serrano i Plana, Núria, Díaz Cruz, José Manuel, Esteban i Cortada, Miquel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/140559
Acceso en línea:https://hdl.handle.net/2445/140559
Access Level:acceso abierto
Palabra clave:Voltametria
Iridi
Voltammetry
Iridium
id ES_7e0fb7df7ff103fe2ebb83ff22f18095
oai_identifier_str oai:recercat.cat:2445/140559
network_acronym_str ES
network_name_str España
repository_id_str
spelling Screen-printed electrodes for the determination of iridium in drugsZaguirre, MarcAriño Blasco, CristinaSerrano i Plana, NúriaDíaz Cruz, José ManuelEsteban i Cortada, MiquelVoltametriaIridiVoltammetryIridiumAmong the impurities that must be controlled in drugs and pharmaceuticals, metal ions are considered. These metal impurities appear in those products because of their use as catalysts. Although Pharmacopeias recommend ICP based methods for their determination, the use of electroanalytical techniques can be considered as a sensible, selective and non-expensive alternative for the determination of heavy metal ions in general and metal impurities in particular. In the present work, we propose a differential pulse voltammetric method based on the use of carbon based-screen-printed electrodes (graphite, nanotubes or nanofibers) that allows the determination of iridium in drugs at the concentration limits recommended by official organisms. Carbon screen-printed electrode modified with nanotubes (CNT-SPCE) is the sensor that provided the best LOD and LOQ (0.03 and 0.10 mg L-1 respectively). Then, the proposed method was applied to the voltammetric determination of iridium in spiked drug samples purchased in local chemists using CNT-SPCE.Wiley-VCH2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion6 p.application/pdfhttps://hdl.handle.net/2445/140559Articles publicats en revistes (Enginyeria Química i Química Analítica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1002/elan.201800502Electroanalysis, 2018, vol. 30, num. 12, p. 2925-2930https://doi.org/10.1002/elan.201800502(c) Wiley-VCH, 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1405592026-05-29T05:05:01Z
dc.title.none.fl_str_mv Screen-printed electrodes for the determination of iridium in drugs
title Screen-printed electrodes for the determination of iridium in drugs
spellingShingle Screen-printed electrodes for the determination of iridium in drugs
Zaguirre, Marc
Voltametria
Iridi
Voltammetry
Iridium
title_short Screen-printed electrodes for the determination of iridium in drugs
title_full Screen-printed electrodes for the determination of iridium in drugs
title_fullStr Screen-printed electrodes for the determination of iridium in drugs
title_full_unstemmed Screen-printed electrodes for the determination of iridium in drugs
title_sort Screen-printed electrodes for the determination of iridium in drugs
dc.creator.none.fl_str_mv Zaguirre, Marc
Ariño Blasco, Cristina
Serrano i Plana, Núria
Díaz Cruz, José Manuel
Esteban i Cortada, Miquel
author Zaguirre, Marc
author_facet Zaguirre, Marc
Ariño Blasco, Cristina
Serrano i Plana, Núria
Díaz Cruz, José Manuel
Esteban i Cortada, Miquel
author_role author
author2 Ariño Blasco, Cristina
Serrano i Plana, Núria
Díaz Cruz, José Manuel
Esteban i Cortada, Miquel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Voltametria
Iridi
Voltammetry
Iridium
topic Voltametria
Iridi
Voltammetry
Iridium
description Among the impurities that must be controlled in drugs and pharmaceuticals, metal ions are considered. These metal impurities appear in those products because of their use as catalysts. Although Pharmacopeias recommend ICP based methods for their determination, the use of electroanalytical techniques can be considered as a sensible, selective and non-expensive alternative for the determination of heavy metal ions in general and metal impurities in particular. In the present work, we propose a differential pulse voltammetric method based on the use of carbon based-screen-printed electrodes (graphite, nanotubes or nanofibers) that allows the determination of iridium in drugs at the concentration limits recommended by official organisms. Carbon screen-printed electrode modified with nanotubes (CNT-SPCE) is the sensor that provided the best LOD and LOQ (0.03 and 0.10 mg L-1 respectively). Then, the proposed method was applied to the voltammetric determination of iridium in spiked drug samples purchased in local chemists using CNT-SPCE.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/140559
url https://hdl.handle.net/2445/140559
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/elan.201800502
Electroanalysis, 2018, vol. 30, num. 12, p. 2925-2930
https://doi.org/10.1002/elan.201800502
dc.rights.none.fl_str_mv (c) Wiley-VCH, 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley-VCH, 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Química i Química Analítica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411709368664064
score 15.812429

Similares en LA Referencia