Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation

Biological differences between males and females change the course of different diseases and affect therapeutic measures' responses. Heart failure is not an exception to these differences. Women account for a minority of patients on the waiting list for heart transplantation or other advanced h...

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Autores: García Cosío, María Dolores, González Vílchez, Francisco, López Vilella, Raquel, Barge Caballero, Eduardo, Gómez Bueno, Manuel, Martínez Sellés Oliveria Soares, Manuel, Azorín, José María, Rangel Sousa, Diego, González Costello, José, Delgado, Juan F., Et al.
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/10278
Acceso en línea:http://hdl.handle.net/11268/10278
Access Level:acceso abierto
Palabra clave:Insuficiencia cardiaca
Enfermedad cardiovascular
Trasplante de órganos
Distribución por sexo
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spelling Influence of Gender in Advanced Heart Failure Therapies and Outcome Following TransplantationGarcía Cosío, María DoloresGonzález Vílchez, FranciscoLópez Vilella, RaquelBarge Caballero, EduardoGómez Bueno, ManuelMartínez Sellés Oliveria Soares, ManuelAzorín, José MaríaRangel Sousa, DiegoGonzález Costello, JoséDelgado, Juan F.Et al.Insuficiencia cardiacaEnfermedad cardiovascularTrasplante de órganosDistribución por sexoBiological differences between males and females change the course of different diseases and affect therapeutic measures' responses. Heart failure is not an exception to these differences. Women account for a minority of patients on the waiting list for heart transplantation or other advanced heart failure therapies. The reason for this under-representation is unknown. Men have a worse cardiovascular risk profile and suffer more often from ischemic heart disease. Conversely, transplanted women are younger and more frequently have non-ischemic cardiac disorders. Women's poorer survival on the waiting list for heart transplantation has been previously described, but this trend has been corrected in recent years. The use of ventricular assist devices in women is progressively increasing, with comparable results than in men. The indication rate for a heart transplant in women (number of women on the waiting list for millions of habitants) has remained unchanged over the past 25 years. Long-term results of heart transplants are equal for both men and women. We have analyzed the data of a national registry of heart transplant patients to look for possible future directions for a more in-depth study of sex differences in this area. We have analyzed 1-year outcomes of heart transplant recipients. We found similar results in men and women and no sex-related interactions with any of the factors related to survival or differences in death causes between men and women. We should keep trying to approach sex differences in prospective studies to confirm if they deserve a different approach, which is not supported by current evidence.20212021-07-3120212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/10278reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/102782026-06-11T12:41:27Z
dc.title.none.fl_str_mv Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation
title Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation
spellingShingle Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation
García Cosío, María Dolores
Insuficiencia cardiaca
Enfermedad cardiovascular
Trasplante de órganos
Distribución por sexo
title_short Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation
title_full Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation
title_fullStr Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation
title_full_unstemmed Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation
title_sort Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation
dc.creator.none.fl_str_mv García Cosío, María Dolores
González Vílchez, Francisco
López Vilella, Raquel
Barge Caballero, Eduardo
Gómez Bueno, Manuel
Martínez Sellés Oliveria Soares, Manuel
Azorín, José María
Rangel Sousa, Diego
González Costello, José
Delgado, Juan F.
Et al.
author García Cosío, María Dolores
author_facet García Cosío, María Dolores
González Vílchez, Francisco
López Vilella, Raquel
Barge Caballero, Eduardo
Gómez Bueno, Manuel
Martínez Sellés Oliveria Soares, Manuel
Azorín, José María
Rangel Sousa, Diego
González Costello, José
Delgado, Juan F.
Et al.
author_role author
author2 González Vílchez, Francisco
López Vilella, Raquel
Barge Caballero, Eduardo
Gómez Bueno, Manuel
Martínez Sellés Oliveria Soares, Manuel
Azorín, José María
Rangel Sousa, Diego
González Costello, José
Delgado, Juan F.
Et al.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Insuficiencia cardiaca
Enfermedad cardiovascular
Trasplante de órganos
Distribución por sexo
topic Insuficiencia cardiaca
Enfermedad cardiovascular
Trasplante de órganos
Distribución por sexo
description Biological differences between males and females change the course of different diseases and affect therapeutic measures' responses. Heart failure is not an exception to these differences. Women account for a minority of patients on the waiting list for heart transplantation or other advanced heart failure therapies. The reason for this under-representation is unknown. Men have a worse cardiovascular risk profile and suffer more often from ischemic heart disease. Conversely, transplanted women are younger and more frequently have non-ischemic cardiac disorders. Women's poorer survival on the waiting list for heart transplantation has been previously described, but this trend has been corrected in recent years. The use of ventricular assist devices in women is progressively increasing, with comparable results than in men. The indication rate for a heart transplant in women (number of women on the waiting list for millions of habitants) has remained unchanged over the past 25 years. Long-term results of heart transplants are equal for both men and women. We have analyzed the data of a national registry of heart transplant patients to look for possible future directions for a more in-depth study of sex differences in this area. We have analyzed 1-year outcomes of heart transplant recipients. We found similar results in men and women and no sex-related interactions with any of the factors related to survival or differences in death causes between men and women. We should keep trying to approach sex differences in prospective studies to confirm if they deserve a different approach, which is not supported by current evidence.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-07-31
2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/10278
url http://hdl.handle.net/11268/10278
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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