The interplay between Caenorhabditis elegans larval development and Orsay virus infection

The development of Caenorhabditis elegans is tightly regulated and highly sensitive to environmental cues, including pathogens. While the effects of bacterial and fungal infections on development have been studied, the influence of viral infections remains poorly understood. We investigate the bidir...

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Detalhes bibliográficos
Autores: Melero, Izan, Castiglioni, Victoria G., Olmo-Uceda, María J., Villena-Jiménez, Ana, Olmedo López, María, González, Rubén, Santiago F., Elena
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/180668
Acesso em linha:https://hdl.handle.net/11441/180668
https://doi.org/10.1016/j.isci.2025.114193
Access Level:acceso abierto
Palavra-chave:Immunology
Virology
Developmental Biology
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spelling The interplay between Caenorhabditis elegans larval development and Orsay virus infectionMelero, IzanCastiglioni, Victoria G.Olmo-Uceda, María J.Villena-Jiménez, AnaOlmedo López, MaríaGonzález, RubénSantiago F., ElenaImmunologyVirologyDevelopmental BiologyThe development of Caenorhabditis elegans is tightly regulated and highly sensitive to environmental cues, including pathogens. While the effects of bacterial and fungal infections on development have been studied, the influence of viral infections remains poorly understood. We investigate the bidirectional relationship between C. elegans larval development and infection by its natural enteric pathogen Orsay virus (OrV). We show that OrV can replicate efficiently during molting periods and that infection initiated in more developed larvae leads to significantly higher viral loads and broader intestinal cell infection. Conversely, OrV infection perturbs the expression of developmental regulators and alters the timing of larval transitions: it accelerates the first molt and delays the subsequent stages, ultimately resynchronizing overall developmental timing. These findings suggest that developmental transitions create windows of altered antiviral capacity. Our work highlights trade-offs between developmental progression and immune competence, offering new insights into how host-pathogen interactions are shaped by development.Cell PressGenéticaBIO371: Genética del Desarrollo en Organismos Modelo2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/180668https://doi.org/10.1016/j.isci.2025.114193reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésiScience, 28 (12), 114193.https://www.cell.com/iscience/fulltext/S2589-0042(25)02454-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS258900422502454X%3Fshowall%3Dtrueinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1806682026-06-17T12:51:07Z
dc.title.none.fl_str_mv The interplay between Caenorhabditis elegans larval development and Orsay virus infection
title The interplay between Caenorhabditis elegans larval development and Orsay virus infection
spellingShingle The interplay between Caenorhabditis elegans larval development and Orsay virus infection
Melero, Izan
Immunology
Virology
Developmental Biology
title_short The interplay between Caenorhabditis elegans larval development and Orsay virus infection
title_full The interplay between Caenorhabditis elegans larval development and Orsay virus infection
title_fullStr The interplay between Caenorhabditis elegans larval development and Orsay virus infection
title_full_unstemmed The interplay between Caenorhabditis elegans larval development and Orsay virus infection
title_sort The interplay between Caenorhabditis elegans larval development and Orsay virus infection
dc.creator.none.fl_str_mv Melero, Izan
Castiglioni, Victoria G.
Olmo-Uceda, María J.
Villena-Jiménez, Ana
Olmedo López, María
González, Rubén
Santiago F., Elena
author Melero, Izan
author_facet Melero, Izan
Castiglioni, Victoria G.
Olmo-Uceda, María J.
Villena-Jiménez, Ana
Olmedo López, María
González, Rubén
Santiago F., Elena
author_role author
author2 Castiglioni, Victoria G.
Olmo-Uceda, María J.
Villena-Jiménez, Ana
Olmedo López, María
González, Rubén
Santiago F., Elena
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Genética
BIO371: Genética del Desarrollo en Organismos Modelo
dc.subject.none.fl_str_mv Immunology
Virology
Developmental Biology
topic Immunology
Virology
Developmental Biology
description The development of Caenorhabditis elegans is tightly regulated and highly sensitive to environmental cues, including pathogens. While the effects of bacterial and fungal infections on development have been studied, the influence of viral infections remains poorly understood. We investigate the bidirectional relationship between C. elegans larval development and infection by its natural enteric pathogen Orsay virus (OrV). We show that OrV can replicate efficiently during molting periods and that infection initiated in more developed larvae leads to significantly higher viral loads and broader intestinal cell infection. Conversely, OrV infection perturbs the expression of developmental regulators and alters the timing of larval transitions: it accelerates the first molt and delays the subsequent stages, ultimately resynchronizing overall developmental timing. These findings suggest that developmental transitions create windows of altered antiviral capacity. Our work highlights trade-offs between developmental progression and immune competence, offering new insights into how host-pathogen interactions are shaped by development.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/180668
https://doi.org/10.1016/j.isci.2025.114193
url https://hdl.handle.net/11441/180668
https://doi.org/10.1016/j.isci.2025.114193
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv iScience, 28 (12), 114193.
https://www.cell.com/iscience/fulltext/S2589-0042(25)02454-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS258900422502454X%3Fshowall%3Dtrue
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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