Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal method

Surface modification, encompassing both chemical and physical features, plays a crucial role in fulfilling the requirements of biomaterial applications and also improves their performance. Due to that, this study focuses on the optimization of morphology and functionalization of hydroxyapatite (HAP)...

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Detalles Bibliográficos
Autores: Mohandes, Fatemeh, Gómez, Elvira, Serrà i Ramos, Albert
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::7a788122b22022f9f1f5091e63e240e0
Acceso en línea:https://hdl.handle.net/2445/229209
Access Level:acceso abierto
Palabra clave:Biocompatibilitat
Superfícies hidrofòbiques
Alteració hidrotermal
Biocompatibility
Hydrophobic surfaces
Hydrothermal alteration
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spelling Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal methodMohandes, FatemehGómez, ElviraSerrà i Ramos, AlbertBiocompatibilitatSuperfícies hidrofòbiquesAlteració hidrotermalBiocompatibilityHydrophobic surfacesHydrothermal alterationSurface modification, encompassing both chemical and physical features, plays a crucial role in fulfilling the requirements of biomaterial applications and also improves their performance. Due to that, this study focuses on the optimization of morphology and functionalization of hydroxyapatite (HAP). For this purpose, hydrothermal growth of HAP on (fluorine tin oxide) FTO is carried out in the presence of calcium and phosphate precursors with Ca/P molar ratio of 1.67:1 in the solution. Trisodium nitrilotriacetic acid (NTA) is used as a chelating additive for the first time during hydrothermal process at temperature between 120 and 180 °C for 16–24 h. Further studies on the effect of NTA concentration on HAP formation indicate that hierarchical structures are formed in the presence of NTA with NTA/Ca molar ratio of 1:1 at temperature between 150 and 180 °C for 24 h, improving crystallinity as temperature increasing. To facilitate the functionalization of HAP, the layer deposited at 180 °C with NTA/Ca molar ratio of 1:1 is peeled using two different reagents, Fluoromount™ and polyvinyl alcohol (PVA). The HAP peeled with PVA shows no relevant morphological changes in SEM images, indicating a successful peeling process using PVA. After that, the HAP powders are functionalized with alendronate (AL) molecules and studied using ATR-FTIR, XPS and BET techniques. Chemical shift of PO43− vibrations and appearance of the new peaks assigned to the –NH2 group demonstrate successful AL-functionalization. The AL-HAP hierarchical structures fabricated with the aid of NTA can be introduced as multifunctional biomaterials for future bio-applications.Elsevier B.V.2026202620242026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/229209Articles publicats en revistes (Ciència dels Materials i Química Física)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.ceramint.2024.03.027Ceramics International, 2024, vol. 50, p. 19283-19292https://doi.org/10.1016/j.ceramint.2024.03.027cc-by (c) Mohandes, Fatemeh et al., 2024http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::7a788122b22022f9f1f5091e63e240e02026-05-29T05:05:01Z
dc.title.none.fl_str_mv Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal method
title Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal method
spellingShingle Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal method
Mohandes, Fatemeh
Biocompatibilitat
Superfícies hidrofòbiques
Alteració hidrotermal
Biocompatibility
Hydrophobic surfaces
Hydrothermal alteration
title_short Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal method
title_full Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal method
title_fullStr Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal method
title_full_unstemmed Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal method
title_sort Surface modification of hierarchical hydroxyapatite fabricated via hydrothermal method
dc.creator.none.fl_str_mv Mohandes, Fatemeh
Gómez, Elvira
Serrà i Ramos, Albert
author Mohandes, Fatemeh
author_facet Mohandes, Fatemeh
Gómez, Elvira
Serrà i Ramos, Albert
author_role author
author2 Gómez, Elvira
Serrà i Ramos, Albert
author2_role author
author
dc.subject.none.fl_str_mv Biocompatibilitat
Superfícies hidrofòbiques
Alteració hidrotermal
Biocompatibility
Hydrophobic surfaces
Hydrothermal alteration
topic Biocompatibilitat
Superfícies hidrofòbiques
Alteració hidrotermal
Biocompatibility
Hydrophobic surfaces
Hydrothermal alteration
description Surface modification, encompassing both chemical and physical features, plays a crucial role in fulfilling the requirements of biomaterial applications and also improves their performance. Due to that, this study focuses on the optimization of morphology and functionalization of hydroxyapatite (HAP). For this purpose, hydrothermal growth of HAP on (fluorine tin oxide) FTO is carried out in the presence of calcium and phosphate precursors with Ca/P molar ratio of 1.67:1 in the solution. Trisodium nitrilotriacetic acid (NTA) is used as a chelating additive for the first time during hydrothermal process at temperature between 120 and 180 °C for 16–24 h. Further studies on the effect of NTA concentration on HAP formation indicate that hierarchical structures are formed in the presence of NTA with NTA/Ca molar ratio of 1:1 at temperature between 150 and 180 °C for 24 h, improving crystallinity as temperature increasing. To facilitate the functionalization of HAP, the layer deposited at 180 °C with NTA/Ca molar ratio of 1:1 is peeled using two different reagents, Fluoromount™ and polyvinyl alcohol (PVA). The HAP peeled with PVA shows no relevant morphological changes in SEM images, indicating a successful peeling process using PVA. After that, the HAP powders are functionalized with alendronate (AL) molecules and studied using ATR-FTIR, XPS and BET techniques. Chemical shift of PO43− vibrations and appearance of the new peaks assigned to the –NH2 group demonstrate successful AL-functionalization. The AL-HAP hierarchical structures fabricated with the aid of NTA can be introduced as multifunctional biomaterials for future bio-applications.
publishDate 2024
dc.date.none.fl_str_mv 2024
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/229209
url https://hdl.handle.net/2445/229209
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.ceramint.2024.03.027
Ceramics International, 2024, vol. 50, p. 19283-19292
https://doi.org/10.1016/j.ceramint.2024.03.027
dc.rights.none.fl_str_mv cc-by (c) Mohandes, Fatemeh et al., 2024
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Mohandes, Fatemeh et al., 2024
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Ciència dels Materials i Química Física)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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