Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer

[Purpose] The aim of this study was to analysis of the clinicopathological characteristics and prognosis of colorectal cancer (CRC) under the age of 50 years.

Detalhes bibliográficos
Autores: Viñal, David, Martínez-Recio, S., Ruiz, I., Jiménez-Bou, Diego, Peña, J., Martin-Montalvo, G., Rueda-Lara, A., Alameda, M., Prieto, Ignacio, Muñoz, Alberto, Rodríguez-Cobos, Javier, Bustamante-Madrid, Pilar, Larriba, María Jesús, Ghanem, Ismael, Fernández-Barral, Asunción, Feliu, Jaime, Barbáchano, Antonio, González-Sancho, José Manuel, Burgos, Aurora, Pastrián, L. G., Rodríguez-Salas, Nuria
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/307140
Acesso em linha:http://hdl.handle.net/10261/307140
Access Level:acceso abierto
Palavra-chave:Prognosis
Young adult
Colorectal cancer
Screening
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spelling Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancerViñal, DavidMartínez-Recio, S.Ruiz, I.Jiménez-Bou, DiegoPeña, J.Martin-Montalvo, G.Rueda-Lara, A.Alameda, M.Prieto, IgnacioMuñoz, AlbertoRodríguez-Cobos, JavierBustamante-Madrid, PilarLarriba, María JesúsGhanem, IsmaelFernández-Barral, AsunciónFeliu, JaimeBarbáchano, AntonioGonzález-Sancho, José ManuelBurgos, AuroraPastrián, L. G.Rodríguez-Salas, NuriaPrognosisYoung adultColorectal cancerScreening[Purpose] The aim of this study was to analysis of the clinicopathological characteristics and prognosis of colorectal cancer (CRC) under the age of 50 years.[Methods] Between January 2009 and December 2018, 1,126 primary CRC patients were included from National Health Insurance Service Ilsan Hospital. The patients were divided into group 1 (n=111, ≤50 years) and group 2 (n=1,015, >50 years). The clinicopathologic features and prognostic outcomes were compared. In addition, to analyze whether there were any differences of those characteristics in 3 groups, patients aged under 50 years were divided into their 20s, 30s, and 40s.[Results] Group 1 had a slightly higher distribution in the left colon and rectum, lower T stage I and higher T stage IV rate, and a significantly higher distribution in stage N2 than group 2 (30.6%:16.3%, P<0.001). Poor histological differentiation of tumors was significantly high in group 1 (P=0.003). The 5-year survival rate for those in their 30s (69.2%) and 40s (91.6%) was higher than those in their 20s who died immediately after surgery (P<0.001). The 5-year disease-free survival rate was also confirmed to be meaningful for each age group, with 0% in their 20s, 53.8% in their 30s, 79.2% in their 40s (P<0.001).[Conclusion] Although the age was not an independent prognostic factor for overall survival in this study, the early onset group of CRCs is more advanced at the time of diagnosis and has a more aggressive histologic type.Peer reviewedKorean Society of ColoproctologyConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320222023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/307140reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3393/ac.2021.00976.0139Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3071402026-05-22T06:33:51Z
dc.title.none.fl_str_mv Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer
title Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer
spellingShingle Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer
Viñal, David
Prognosis
Young adult
Colorectal cancer
Screening
title_short Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer
title_full Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer
title_fullStr Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer
title_full_unstemmed Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer
title_sort Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer
dc.creator.none.fl_str_mv Viñal, David
Martínez-Recio, S.
Ruiz, I.
Jiménez-Bou, Diego
Peña, J.
Martin-Montalvo, G.
Rueda-Lara, A.
Alameda, M.
Prieto, Ignacio
Muñoz, Alberto
Rodríguez-Cobos, Javier
Bustamante-Madrid, Pilar
Larriba, María Jesús
Ghanem, Ismael
Fernández-Barral, Asunción
Feliu, Jaime
Barbáchano, Antonio
González-Sancho, José Manuel
Burgos, Aurora
Pastrián, L. G.
Rodríguez-Salas, Nuria
author Viñal, David
author_facet Viñal, David
Martínez-Recio, S.
Ruiz, I.
Jiménez-Bou, Diego
Peña, J.
Martin-Montalvo, G.
Rueda-Lara, A.
Alameda, M.
Prieto, Ignacio
Muñoz, Alberto
Rodríguez-Cobos, Javier
Bustamante-Madrid, Pilar
Larriba, María Jesús
Ghanem, Ismael
Fernández-Barral, Asunción
Feliu, Jaime
Barbáchano, Antonio
González-Sancho, José Manuel
Burgos, Aurora
Pastrián, L. G.
Rodríguez-Salas, Nuria
author_role author
author2 Martínez-Recio, S.
Ruiz, I.
Jiménez-Bou, Diego
Peña, J.
Martin-Montalvo, G.
Rueda-Lara, A.
Alameda, M.
Prieto, Ignacio
Muñoz, Alberto
Rodríguez-Cobos, Javier
Bustamante-Madrid, Pilar
Larriba, María Jesús
Ghanem, Ismael
Fernández-Barral, Asunción
Feliu, Jaime
Barbáchano, Antonio
González-Sancho, José Manuel
Burgos, Aurora
Pastrián, L. G.
Rodríguez-Salas, Nuria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Prognosis
Young adult
Colorectal cancer
Screening
topic Prognosis
Young adult
Colorectal cancer
Screening
description [Purpose] The aim of this study was to analysis of the clinicopathological characteristics and prognosis of colorectal cancer (CRC) under the age of 50 years.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/307140
url http://hdl.handle.net/10261/307140
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3393/ac.2021.00976.0139
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Korean Society of Coloproctology
publisher.none.fl_str_mv Korean Society of Coloproctology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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