Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation

High-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the reinforcing effects of palatable foods and is crucially involved in the develo...

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Autores: Gutiérrez Martos, Miriam, 1989-, Girard, Benoît, Mendonça Netto, Sueli, Perroy, Julie, Valjent, Emmanuel, Maldonado, Rafael, 1961-, Martín Sánchez, Miquel, 1971-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/34825
Acceso en línea:http://hdl.handle.net/10230/34825
http://dx.doi.org/10.1111/adb.12541
Access Level:acceso abierto
Palabra clave:Neuroinflammation
Neuronal plasticity
Nucleus accumbens
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spelling Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activationGutiérrez Martos, Miriam, 1989-Girard, BenoîtMendonça Netto, SueliPerroy, JulieValjent, EmmanuelMaldonado, Rafael, 1961-Martín Sánchez, Miquel, 1971-NeuroinflammationNeuronal plasticityNucleus accumbensHigh-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the reinforcing effects of palatable foods and is crucially involved in the development of eating disorders. We describe that prolonged exposure to high-caloric chocolate cafeteria diet leads to overeating and overweight in mice. NAc functionality was altered in these mice, presenting structural plasticity modifications in medium spiny neurons, increased expression of neuroinflammatory factors and activated microglia, and abnormal responses after amphetamine-induced hyperlocomotion. Chronic inactivation of microglia normalized these neurobiological and behavioural alterations exclusively in mice exposed to cafeteria diet. Our data suggest that prolonged exposure to cafeteria diet produces neuroplastic and functional changes in the NAc that can modify feeding behaviour. Microglia activation and neuroinflammation play an important role in the development of these neurobiological alterations.This work was supported by the European Commission, FP7 (#HEALTH‐F2‐2013‐602891) to R.M.; the Spanish Ministerio de Economía y Competitividad‐MINECO (#SAF2014‐59648‐P‐FEDER), the Spanish Instituto de Salud Carlos III, RETICS‐RTA (#RD12/0028/0023‐FEDER) and the Generalitat de Catalunya, AGAUR (#2014‐SGR‐1547) to R.M. The financial support of the Fundació La Marató‐TV3 (#201620‐30) is also acknowledged. We would like to thank the Advance Light Microscopy Unit of the Center for Genomic Regulation for their technical assistance on the acquisition and processing of microscopy images. S. M‐N. was supported by CAPES fellowship of the Brazilian Government (Programa Ciência Sem Fronteiras).Wiley-Blackwell20182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34825http://dx.doi.org/10.1111/adb.12541reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésAddiction Biology. 2018 Mar;23(2):735-49info:eu-repo/grantAgreement/EC/FP7/602891info:eu-repo/grantAgreement/ES/1PE/SAF2014-59648-PThis is the pre-peer reviewed version of the following article: Gutiérrez-Martos M, Girard B, Mendonça-Netto S, Perroy J, Valjent E, Maldonado R et al. Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation. Addict Biol. 2018 Mar; 23(2): 735-749, which has been published in final form at http://dx.doi.org/10.1111/adb.12541. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/348252026-06-12T07:21:37Z
dc.title.none.fl_str_mv Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
title Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
spellingShingle Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
Gutiérrez Martos, Miriam, 1989-
Neuroinflammation
Neuronal plasticity
Nucleus accumbens
title_short Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
title_full Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
title_fullStr Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
title_full_unstemmed Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
title_sort Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
dc.creator.none.fl_str_mv Gutiérrez Martos, Miriam, 1989-
Girard, Benoît
Mendonça Netto, Sueli
Perroy, Julie
Valjent, Emmanuel
Maldonado, Rafael, 1961-
Martín Sánchez, Miquel, 1971-
author Gutiérrez Martos, Miriam, 1989-
author_facet Gutiérrez Martos, Miriam, 1989-
Girard, Benoît
Mendonça Netto, Sueli
Perroy, Julie
Valjent, Emmanuel
Maldonado, Rafael, 1961-
Martín Sánchez, Miquel, 1971-
author_role author
author2 Girard, Benoît
Mendonça Netto, Sueli
Perroy, Julie
Valjent, Emmanuel
Maldonado, Rafael, 1961-
Martín Sánchez, Miquel, 1971-
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuroinflammation
Neuronal plasticity
Nucleus accumbens
topic Neuroinflammation
Neuronal plasticity
Nucleus accumbens
description High-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the reinforcing effects of palatable foods and is crucially involved in the development of eating disorders. We describe that prolonged exposure to high-caloric chocolate cafeteria diet leads to overeating and overweight in mice. NAc functionality was altered in these mice, presenting structural plasticity modifications in medium spiny neurons, increased expression of neuroinflammatory factors and activated microglia, and abnormal responses after amphetamine-induced hyperlocomotion. Chronic inactivation of microglia normalized these neurobiological and behavioural alterations exclusively in mice exposed to cafeteria diet. Our data suggest that prolonged exposure to cafeteria diet produces neuroplastic and functional changes in the NAc that can modify feeding behaviour. Microglia activation and neuroinflammation play an important role in the development of these neurobiological alterations.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34825
http://dx.doi.org/10.1111/adb.12541
url http://hdl.handle.net/10230/34825
http://dx.doi.org/10.1111/adb.12541
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Addiction Biology. 2018 Mar;23(2):735-49
info:eu-repo/grantAgreement/EC/FP7/602891
info:eu-repo/grantAgreement/ES/1PE/SAF2014-59648-P
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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