Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia

The retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed up throughout the evolution of the disease. As opposed...

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Autores: García Martín, Elena Salobrar, Hoz Montañana, María Rosa De, Ramírez Sebastián, Ana Isabel, Salazar Corral, Juan José, Rojas Lozano, María Del Pilar, López Cuenca, Inés, Fernández Albarral, José, Ramírez Sebastián, José Manuel
Tipo de recurso: capítulo de libro
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8703
Acceso en línea:https://hdl.handle.net/20.500.14352/8703
Access Level:acceso abierto
Palabra clave:616.894-053.9
617.735-073
616.8-003.8
Alzheimer’s disease
Biomarker
Neurodegeneration
Retina
Visual system
Neurociencias (Medicina)
Oftalmología
Optometría
Técnicas de la imagen
2490 Neurociencias
3201.09 Oftalmología
2209.15 Optometría
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s DementiaGarcía Martín, Elena SalobrarHoz Montañana, María Rosa DeRamírez Sebastián, Ana IsabelSalazar Corral, Juan JoséRojas Lozano, María Del PilarLópez Cuenca, InésFernández Albarral, JoséRamírez Sebastián, José Manuel616.894-053.9617.735-073616.8-003.8Alzheimer’s diseaseBiomarkerNeurodegenerationRetinaVisual systemNeurociencias (Medicina)OftalmologíaOptometríaTécnicas de la imagen2490 Neurociencias3201.09 Oftalmología2209.15 OptometríaThe retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed up throughout the evolution of the disease. As opposed to other CNS structures, the eye is easily accessible for in vivo observation. Retinal organization allows for the identification of its different neurons, and in consequence, detection of minimal changes taking place during neurodegeneration is possible. Functional vision studies performed on AD patients in recent years have shown how visual acuity, contrast sensitivity, color vision, and visual integration vary with the progression of neurodegeneration. The development of optical coherence tomography in ophthalmology has meant a breakthrough in retinal exploratory techniques, allowing the obtention of high-resolution images using light. This technique enables retinal analysis in the earliest stages of AD, being considered as a biomarker of neuronal damage. Given AD’s high prevalence and its expected increase, it is important to perform easy tests that cause minimal discomfort to the patients at a low cost while offering abundant information on the stage of the disease.Codon PublicationsUniversidad Complutense de Madrid20192019-12-2020192019-12-20book parthttp://purl.org/coar/resource_type/c_3248info:eu-repo/semantics/bookPartapplication/pdfhttps://hdl.handle.net/20.500.14352/8703reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 3.0 Españahttps://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/87032026-06-02T12:44:21Z
dc.title.none.fl_str_mv Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia
title Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia
spellingShingle Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia
García Martín, Elena Salobrar
616.894-053.9
617.735-073
616.8-003.8
Alzheimer’s disease
Biomarker
Neurodegeneration
Retina
Visual system
Neurociencias (Medicina)
Oftalmología
Optometría
Técnicas de la imagen
2490 Neurociencias
3201.09 Oftalmología
2209.15 Optometría
title_short Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia
title_full Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia
title_fullStr Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia
title_full_unstemmed Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia
title_sort Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia
dc.creator.none.fl_str_mv García Martín, Elena Salobrar
Hoz Montañana, María Rosa De
Ramírez Sebastián, Ana Isabel
Salazar Corral, Juan José
Rojas Lozano, María Del Pilar
López Cuenca, Inés
Fernández Albarral, José
Ramírez Sebastián, José Manuel
author García Martín, Elena Salobrar
author_facet García Martín, Elena Salobrar
Hoz Montañana, María Rosa De
Ramírez Sebastián, Ana Isabel
Salazar Corral, Juan José
Rojas Lozano, María Del Pilar
López Cuenca, Inés
Fernández Albarral, José
Ramírez Sebastián, José Manuel
author_role author
author2 Hoz Montañana, María Rosa De
Ramírez Sebastián, Ana Isabel
Salazar Corral, Juan José
Rojas Lozano, María Del Pilar
López Cuenca, Inés
Fernández Albarral, José
Ramírez Sebastián, José Manuel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.894-053.9
617.735-073
616.8-003.8
Alzheimer’s disease
Biomarker
Neurodegeneration
Retina
Visual system
Neurociencias (Medicina)
Oftalmología
Optometría
Técnicas de la imagen
2490 Neurociencias
3201.09 Oftalmología
2209.15 Optometría
topic 616.894-053.9
617.735-073
616.8-003.8
Alzheimer’s disease
Biomarker
Neurodegeneration
Retina
Visual system
Neurociencias (Medicina)
Oftalmología
Optometría
Técnicas de la imagen
2490 Neurociencias
3201.09 Oftalmología
2209.15 Optometría
description The retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed up throughout the evolution of the disease. As opposed to other CNS structures, the eye is easily accessible for in vivo observation. Retinal organization allows for the identification of its different neurons, and in consequence, detection of minimal changes taking place during neurodegeneration is possible. Functional vision studies performed on AD patients in recent years have shown how visual acuity, contrast sensitivity, color vision, and visual integration vary with the progression of neurodegeneration. The development of optical coherence tomography in ophthalmology has meant a breakthrough in retinal exploratory techniques, allowing the obtention of high-resolution images using light. This technique enables retinal analysis in the earliest stages of AD, being considered as a biomarker of neuronal damage. Given AD’s high prevalence and its expected increase, it is important to perform easy tests that cause minimal discomfort to the patients at a low cost while offering abundant information on the stage of the disease.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-12-20
2019
2019-12-20
dc.type.none.fl_str_mv book part
http://purl.org/coar/resource_type/c_3248
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8703
url https://hdl.handle.net/20.500.14352/8703
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 3.0 España
https://creativecommons.org/licenses/by-nc/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 3.0 España
https://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Codon Publications
publisher.none.fl_str_mv Codon Publications
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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