New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia

The levels and roles of lipid mediators can be modified in response to nutritional stimuli. The aim of this study was to investigate shifts in oxylipin and sphingolipid profiles stimulated by a hypercholesterolemic (HC) diet along with the modulating effects of onion introduced as an antioxidant fun...

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Authors: González Peña, Diana, Checa, Antonio, Ancos, Begoña de, Wheelock, Craig E., Sánchez-Moreno, Concepción
Format: article
Status:Published version
Publication Date:2017
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/171429
Online Access:http://hdl.handle.net/10261/171429
Access Level:Open access
Keyword:Eicosanoids
Mass spectrometry
Lipid profiling
Sphingolipids
Oxylipins
Inflammation
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spelling New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemiaGonzález Peña, DianaCheca, AntonioAncos, Begoña deWheelock, Craig E.Sánchez-Moreno, ConcepciónEicosanoidsMass spectrometryLipid profilingSphingolipidsOxylipinsInflammationThe levels and roles of lipid mediators can be modified in response to nutritional stimuli. The aim of this study was to investigate shifts in oxylipin and sphingolipid profiles stimulated by a hypercholesterolemic (HC) diet along with the modulating effects of onion introduced as an antioxidant functional ingredient characterized in the diet (HCO). Oxylipin and sphingolipid profiles were determined in plasma and tissues from Wistar rats using LC-MS/MS. Plasma ω-3 and ω-6 PUFA-derived oxylipins decreased in rats after 7 weeks of HC feeding, but did not evidence a further shift with HCO diet. Onion ingredient supplementation modulated the hepatic concentrations of prostaglandins and enhanced ω-3 oxylipins in the liver of HCO-fed rats relative to the HC group. The HC diet induced shifts in plasma sphingolipids, increasing sphingoid bases, dihydroceramides and ceramides, whilst the sphingomyelin, hexosylceramide and lactosylceramide families decreased. The HCO diet modified some HC diet-induced changes in sphingolipids in liver and spleen tissue. Onion supplementation effected changes in lipid mediator levels in diet-induced hypercholesterolemic Wistar rats. The potential of onion as regulator of pro-inflammatory mediators, and possible enhancer of pro-resolution pathways, warrants further study of the interaction of functional ingredients with bioactive lipid mediators and their potential impact on inflammation, oxidative stress and organ dysfunction.This work was supported by the Spanish Ministry of Science and Innovation [AGL2010-15910 (subprogram ALI)]. CEW was funded by the Swedish Heart Lung Foundation. DG-P also acknowledge the grant from the Margit and Folke Pehrzon Foundation.Peer ReviewedElsevierMinisterio de Ciencia e Innovación (España)Swedish Heart-Lung FoundationMargit and Folke Pehrzon FoundationConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820172018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/171429reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.redox.2016.12.002Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1714292026-05-22T06:33:51Z
dc.title.none.fl_str_mv New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
title New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
spellingShingle New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
González Peña, Diana
Eicosanoids
Mass spectrometry
Lipid profiling
Sphingolipids
Oxylipins
Inflammation
title_short New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
title_full New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
title_fullStr New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
title_full_unstemmed New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
title_sort New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
dc.creator.none.fl_str_mv González Peña, Diana
Checa, Antonio
Ancos, Begoña de
Wheelock, Craig E.
Sánchez-Moreno, Concepción
author González Peña, Diana
author_facet González Peña, Diana
Checa, Antonio
Ancos, Begoña de
Wheelock, Craig E.
Sánchez-Moreno, Concepción
author_role author
author2 Checa, Antonio
Ancos, Begoña de
Wheelock, Craig E.
Sánchez-Moreno, Concepción
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Swedish Heart-Lung Foundation
Margit and Folke Pehrzon Foundation
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Eicosanoids
Mass spectrometry
Lipid profiling
Sphingolipids
Oxylipins
Inflammation
topic Eicosanoids
Mass spectrometry
Lipid profiling
Sphingolipids
Oxylipins
Inflammation
description The levels and roles of lipid mediators can be modified in response to nutritional stimuli. The aim of this study was to investigate shifts in oxylipin and sphingolipid profiles stimulated by a hypercholesterolemic (HC) diet along with the modulating effects of onion introduced as an antioxidant functional ingredient characterized in the diet (HCO). Oxylipin and sphingolipid profiles were determined in plasma and tissues from Wistar rats using LC-MS/MS. Plasma ω-3 and ω-6 PUFA-derived oxylipins decreased in rats after 7 weeks of HC feeding, but did not evidence a further shift with HCO diet. Onion ingredient supplementation modulated the hepatic concentrations of prostaglandins and enhanced ω-3 oxylipins in the liver of HCO-fed rats relative to the HC group. The HC diet induced shifts in plasma sphingolipids, increasing sphingoid bases, dihydroceramides and ceramides, whilst the sphingomyelin, hexosylceramide and lactosylceramide families decreased. The HCO diet modified some HC diet-induced changes in sphingolipids in liver and spleen tissue. Onion supplementation effected changes in lipid mediator levels in diet-induced hypercholesterolemic Wistar rats. The potential of onion as regulator of pro-inflammatory mediators, and possible enhancer of pro-resolution pathways, warrants further study of the interaction of functional ingredients with bioactive lipid mediators and their potential impact on inflammation, oxidative stress and organ dysfunction.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/171429
url http://hdl.handle.net/10261/171429
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.redox.2016.12.002
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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