Ochratoxin A kinetics: a review of analytical methods and studies in rat model

Ochratoxin A (OTA) is a thermostable mycotoxin that contaminates a great variety of foodstuffs. It is nephrotoxic in all of the mammalian species tested, being the pig the most sensitive one; among rodents, rats are the most susceptible to OTA carcinogenicity. Kinetics, by studying the absorption, d...

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Autores: Vettorazzi, A. (Ariane)|||/items/b1ef6cda-f150-427f-b212-9f29c2c4f557, Gonzalez-Peñas, E. (Elena)|||/items/0e4b9ed7-4224-4664-a4f1-c6403a8c833f, Lopez-de-Cerain, A. (Adela)|||/items/8d95b72a-6816-4612-884b-5cf5c6c172f1
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/37249
Acceso en línea:https://hdl.handle.net/10171/37249
Access Level:acceso abierto
Palabra clave:Ochratoxin A
Kinetics
Analytical techniques
Rat
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spelling Ochratoxin A kinetics: a review of analytical methods and studies in rat modelOchratoxin A kinetics in ratsVettorazzi, A. (Ariane)|||/items/b1ef6cda-f150-427f-b212-9f29c2c4f557Gonzalez-Peñas, E. (Elena)|||/items/0e4b9ed7-4224-4664-a4f1-c6403a8c833fLopez-de-Cerain, A. (Adela)|||/items/8d95b72a-6816-4612-884b-5cf5c6c172f1Ochratoxin AKineticsAnalytical techniquesRatOchratoxin A (OTA) is a thermostable mycotoxin that contaminates a great variety of foodstuffs. It is nephrotoxic in all of the mammalian species tested, being the pig the most sensitive one; among rodents, rats are the most susceptible to OTA carcinogenicity. Kinetics, by studying the absorption, distribution, metabolism and excretion of xenobiotics, is an important tool for the extrapolation of animal toxicity data. The most important kinetic studies performed with OTA in rats have been reviewed, together with the different methods used for OTA quantification in biological matrices. Thirteen studies in Wistar, Sprague-Dawley or F344 rats, using radiolabeled OTA or TLC, HPLC-FLD or HPLC-MS have been summarized. Very often methods validated for food have been directly applied to tissues. Strain, sex and age differences have been detected but the interpretation is difficult due to the different experimental conditions, and the connection of the several factors that may account for these differences.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20152015-01-1220142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/37249reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/372492026-06-21T12:47:57Z
dc.title.none.fl_str_mv Ochratoxin A kinetics: a review of analytical methods and studies in rat model
Ochratoxin A kinetics in rats
title Ochratoxin A kinetics: a review of analytical methods and studies in rat model
spellingShingle Ochratoxin A kinetics: a review of analytical methods and studies in rat model
Vettorazzi, A. (Ariane)|||/items/b1ef6cda-f150-427f-b212-9f29c2c4f557
Ochratoxin A
Kinetics
Analytical techniques
Rat
title_short Ochratoxin A kinetics: a review of analytical methods and studies in rat model
title_full Ochratoxin A kinetics: a review of analytical methods and studies in rat model
title_fullStr Ochratoxin A kinetics: a review of analytical methods and studies in rat model
title_full_unstemmed Ochratoxin A kinetics: a review of analytical methods and studies in rat model
title_sort Ochratoxin A kinetics: a review of analytical methods and studies in rat model
dc.creator.none.fl_str_mv Vettorazzi, A. (Ariane)|||/items/b1ef6cda-f150-427f-b212-9f29c2c4f557
Gonzalez-Peñas, E. (Elena)|||/items/0e4b9ed7-4224-4664-a4f1-c6403a8c833f
Lopez-de-Cerain, A. (Adela)|||/items/8d95b72a-6816-4612-884b-5cf5c6c172f1
author Vettorazzi, A. (Ariane)|||/items/b1ef6cda-f150-427f-b212-9f29c2c4f557
author_facet Vettorazzi, A. (Ariane)|||/items/b1ef6cda-f150-427f-b212-9f29c2c4f557
Gonzalez-Peñas, E. (Elena)|||/items/0e4b9ed7-4224-4664-a4f1-c6403a8c833f
Lopez-de-Cerain, A. (Adela)|||/items/8d95b72a-6816-4612-884b-5cf5c6c172f1
author_role author
author2 Gonzalez-Peñas, E. (Elena)|||/items/0e4b9ed7-4224-4664-a4f1-c6403a8c833f
Lopez-de-Cerain, A. (Adela)|||/items/8d95b72a-6816-4612-884b-5cf5c6c172f1
author2_role author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Ochratoxin A
Kinetics
Analytical techniques
Rat
topic Ochratoxin A
Kinetics
Analytical techniques
Rat
description Ochratoxin A (OTA) is a thermostable mycotoxin that contaminates a great variety of foodstuffs. It is nephrotoxic in all of the mammalian species tested, being the pig the most sensitive one; among rodents, rats are the most susceptible to OTA carcinogenicity. Kinetics, by studying the absorption, distribution, metabolism and excretion of xenobiotics, is an important tool for the extrapolation of animal toxicity data. The most important kinetic studies performed with OTA in rats have been reviewed, together with the different methods used for OTA quantification in biological matrices. Thirteen studies in Wistar, Sprague-Dawley or F344 rats, using radiolabeled OTA or TLC, HPLC-FLD or HPLC-MS have been summarized. Very often methods validated for food have been directly applied to tissues. Strain, sex and age differences have been detected but the interpretation is difficult due to the different experimental conditions, and the connection of the several factors that may account for these differences.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01
2014
2014-01-01
2015
2015-01-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/37249
url https://hdl.handle.net/10171/37249
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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