Angiogenic factors for planning fetal surveillance in fetal growth restriction and small-for-gestational-age fetuses

The aim of this study was to assess the added value of the soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio for adjusting the periodicity of ultrasound examinations in early-onset fetal growth restriction (FGR) and small for gestational age (SGA). A prospective, o...

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Detalles Bibliográficos
Autores: Bonacina, Erika|||0000-0002-8042-8247, Mendoza, Manel|||0000-0002-3030-3833, Farràs Llobet, Alba|||0000-0003-2100-7693, García Manau, Pablo, Serrano, Berta|||0000-0002-1264-9195, Hurtado, Ivan|||0000-0002-0084-1710, Ferrer-Oliveras, Raquel|||0000-0001-9942-7589, Illan, Lidia, Armengol-Alsina, Mireia|||0000-0002-2087-5176, Carreras Moratonas, Elena|||0000-0003-3471-7248
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:281799
Acceso en línea:https://ddd.uab.cat/record/281799
https://dx.doi.org/urn:doi:10.1111/1471-0528.17151
Access Level:acceso abierto
Palabra clave:Fetal Doppler
Fetal growth restriction
Fetal surveillance
PlGF
Sflt-1
Small for gestational age
Descripción
Sumario:The aim of this study was to assess the added value of the soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio for adjusting the periodicity of ultrasound examinations in early-onset fetal growth restriction (FGR) and small for gestational age (SGA). A prospective, observational study. Tertiary referral hospital. One hundred and thirty-four single pregnancies with ultrasonographic estimated fetal weight (EFW) below the 10th centile between 20 +0 and 31 +6 weeks of gestation with antegrade umbilical artery flow. The time from Doppler and sFlt-1/PlGF assessment to delivery was recorded and classified into four ranges: <1, <2, <3 and <4 weeks. Sensitivity (Sn), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of sFlt-1/PlGF values to predict the time to delivery. In the SGA cohort, the NPV calculated for an sFlt-1/PlGF cut-off value of 38 was 100% for delivery before 3 weeks, and 98% for delivery before 4 weeks after diagnosis (95% CI 0.89-1.00). In the FGR cohort, the NPV calculated for an sFlt-1/PlGF cut-off value of 38 was 100% for delivery before 2 weeks after diagnosis (95% CI 0.92-1.00). By contrast, more than 50% of cases with an sFlt-1/PlGF value of.

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