Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort study

Background: In current guidelines, staging laparoscopy (SL) is recommended in patients with locally advanced gastric cancer (GC). This study aimed to assess the clinical practice of SL and its association with administration of systemic treatment in a European cohort of GC patients (GASTRODATA). Met...

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Autores: Sędłak, Katarzyna, Pera Román, Manuel, Rawicz-Pruszyński, Karol
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2025
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:dnet:rdupf_______::7f23e7ff5d3808892cc3f85ea7a5b0b5
Acceso en línea:https://hdl.handle.net/10230/72885
http://dx.doi.org/10.1245/s10434-025-17905-6
Access Level:acceso abierto
Palabra clave:Gastric cancer
Multimodal treatment
Staging laparoscopy
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spelling Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort studySędłak, KatarzynaPera Román, ManuelRawicz-Pruszyński, KarolGastric cancerMultimodal treatmentStaging laparoscopyBackground: In current guidelines, staging laparoscopy (SL) is recommended in patients with locally advanced gastric cancer (GC). This study aimed to assess the clinical practice of SL and its association with administration of systemic treatment in a European cohort of GC patients (GASTRODATA). Methods: In this retrospective cohort study, patients with locally advanced GC who underwent multimodal treatment in 24 European centers were analyzed. Patients with early (cT1) or metastatic GC at diagnosis and those with missing data on chemotherapy administration were excluded. Results: Of 2558 patients, 1726 were selected, with 562 (32.6%) undergoing SL. Patients who did not undergo SL were older (72 vs. 65 years; p < 0.001) and had higher Charlson Comorbidity Index scores (- 2: 33.8% vs. 20.5%; p < 0.001). These patients had more complications (30.9% vs. 24.4%; p = 0.005), higher 90-day mortality (4.7% vs. 2.3%; p = 0.017), and were less likely to receive neoadjuvant (35% vs. 78.6%; p < 0.001) or adjuvant (27.1% vs. 33.8%; p = 0.005) chemotherapy. Non-SL patients had higher rates of serosal invasion (pT4: 38.0% vs. 26.0%; p < 0.001) and lymph node metastasis (63.5% vs. 60.4%; p = 0.004). Conclusions: SL was performed in one-third of individuals with locally advanced GC. Absence of SL was associated with higher T-stage discrepancy and decreased utilization of multimodal treatment.Springer2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/72885http://dx.doi.org/10.1245/s10434-025-17905-6reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésAnnals of Surgical Oncology. 2025;32(10):7615-7626© The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:rdupf_______::7f23e7ff5d3808892cc3f85ea7a5b0b52026-06-12T07:21:37Z
dc.title.none.fl_str_mv Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort study
title Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort study
spellingShingle Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort study
Sędłak, Katarzyna
Gastric cancer
Multimodal treatment
Staging laparoscopy
title_short Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort study
title_full Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort study
title_fullStr Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort study
title_full_unstemmed Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort study
title_sort Staging laparoscopy in gastric cancer patients treated with curative intent: A European GASTRODATA cohort study
dc.creator.none.fl_str_mv Sędłak, Katarzyna
Pera Román, Manuel
Rawicz-Pruszyński, Karol
author Sędłak, Katarzyna
author_facet Sędłak, Katarzyna
Pera Román, Manuel
Rawicz-Pruszyński, Karol
author_role author
author2 Pera Román, Manuel
Rawicz-Pruszyński, Karol
author2_role author
author
dc.subject.none.fl_str_mv Gastric cancer
Multimodal treatment
Staging laparoscopy
topic Gastric cancer
Multimodal treatment
Staging laparoscopy
description Background: In current guidelines, staging laparoscopy (SL) is recommended in patients with locally advanced gastric cancer (GC). This study aimed to assess the clinical practice of SL and its association with administration of systemic treatment in a European cohort of GC patients (GASTRODATA). Methods: In this retrospective cohort study, patients with locally advanced GC who underwent multimodal treatment in 24 European centers were analyzed. Patients with early (cT1) or metastatic GC at diagnosis and those with missing data on chemotherapy administration were excluded. Results: Of 2558 patients, 1726 were selected, with 562 (32.6%) undergoing SL. Patients who did not undergo SL were older (72 vs. 65 years; p < 0.001) and had higher Charlson Comorbidity Index scores (- 2: 33.8% vs. 20.5%; p < 0.001). These patients had more complications (30.9% vs. 24.4%; p = 0.005), higher 90-day mortality (4.7% vs. 2.3%; p = 0.017), and were less likely to receive neoadjuvant (35% vs. 78.6%; p < 0.001) or adjuvant (27.1% vs. 33.8%; p = 0.005) chemotherapy. Non-SL patients had higher rates of serosal invasion (pT4: 38.0% vs. 26.0%; p < 0.001) and lymph node metastasis (63.5% vs. 60.4%; p = 0.004). Conclusions: SL was performed in one-third of individuals with locally advanced GC. Absence of SL was associated with higher T-stage discrepancy and decreased utilization of multimodal treatment.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/72885
http://dx.doi.org/10.1245/s10434-025-17905-6
url https://hdl.handle.net/10230/72885
http://dx.doi.org/10.1245/s10434-025-17905-6
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Annals of Surgical Oncology. 2025;32(10):7615-7626
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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