Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation
Understanding the origin and fate of sex chromosomes has been one of the most intriguing questions in biology. In therian (marsupial and eutherian) mammals, most species are characterized by a heteromorphic XX female XY male sex chromosome system. It is commonly accepted that they originated from a...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:321125 |
| Acceso en línea: | https://ddd.uab.cat/record/321125 https://dx.doi.org/urn:doi:10.3389/fcell.2025.1562403 |
| Access Level: | acceso abierto |
| Palabra clave: | Marsupials Meiosis Neo sex-chromosomes inactivation Meiotic sex chromosome Double strand breaks Recombination |
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Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiationMarin Gual, Laia|||0000-0003-1480-0976Hogg, Carolyn J.Chang, J. KingPask, Andrew J.|||0000-0002-1900-2263Renfree, Marilyn B.|||0000-0002-4589-0436Waters, Paul D.|||0000-0002-4689-8747Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151MarsupialsMeiosisNeo sex-chromosomes inactivationMeiotic sex chromosomeDouble strand breaksRecombinationUnderstanding the origin and fate of sex chromosomes has been one of the most intriguing questions in biology. In therian (marsupial and eutherian) mammals, most species are characterized by a heteromorphic XX female XY male sex chromosome system. It is commonly accepted that they originated from a pair of autosomes after gaining a sex-determining function, leading to recombination suppression and subsequent Y chromosome degeneration. Unlike eutherian sex chromosomes which share a pseudo-autosomal region (PAR), the marsupial sex chromosomes are typically tiny and lack any homology. However, there is a lack of empirical evidence on biological systems that represent early stages of sex chromosome differentiation. Here, we describe the meiotic dynamics of an XY1Y2 system in the greater bilby (Macrotis lagotis: family Thylacomyidae) that resulted from a fusion between an autosome and the ancestral X chromosome. We compared the similarities and differences in the regulation of meiosis in two other Australian marsupial species with different sex chromosome systems: the tammar wallaby (Macropus eugenii: family Macropodidae) and the fat-tailed dunnart (Sminthopsis crassicaudata: family Dasyuridae), both with the ancestral XY system. We performed a cytological analysis of meiotic prophase I, including the study of chromosome synapsis, double strand break formation (as a proxy of recombination) and meiotic sex chromosome inactivation. Our results suggest that the neo-PAR in the greater bilby represents an early stage of differentiation, providing new insights into sex chromosome evolution. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/321125https://dx.doi.org/urn:doi:10.3389/fcell.2025.1562403reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-112557GB-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00122open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3211252026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation |
| title |
Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation |
| spellingShingle |
Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation Marin Gual, Laia|||0000-0003-1480-0976 Marsupials Meiosis Neo sex-chromosomes inactivation Meiotic sex chromosome Double strand breaks Recombination |
| title_short |
Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation |
| title_full |
Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation |
| title_fullStr |
Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation |
| title_full_unstemmed |
Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation |
| title_sort |
Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation |
| dc.creator.none.fl_str_mv |
Marin Gual, Laia|||0000-0003-1480-0976 Hogg, Carolyn J. Chang, J. King Pask, Andrew J.|||0000-0002-1900-2263 Renfree, Marilyn B.|||0000-0002-4589-0436 Waters, Paul D.|||0000-0002-4689-8747 Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151 |
| author |
Marin Gual, Laia|||0000-0003-1480-0976 |
| author_facet |
Marin Gual, Laia|||0000-0003-1480-0976 Hogg, Carolyn J. Chang, J. King Pask, Andrew J.|||0000-0002-1900-2263 Renfree, Marilyn B.|||0000-0002-4589-0436 Waters, Paul D.|||0000-0002-4689-8747 Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151 |
| author_role |
author |
| author2 |
Hogg, Carolyn J. Chang, J. King Pask, Andrew J.|||0000-0002-1900-2263 Renfree, Marilyn B.|||0000-0002-4589-0436 Waters, Paul D.|||0000-0002-4689-8747 Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151 |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Marsupials Meiosis Neo sex-chromosomes inactivation Meiotic sex chromosome Double strand breaks Recombination |
| topic |
Marsupials Meiosis Neo sex-chromosomes inactivation Meiotic sex chromosome Double strand breaks Recombination |
| description |
Understanding the origin and fate of sex chromosomes has been one of the most intriguing questions in biology. In therian (marsupial and eutherian) mammals, most species are characterized by a heteromorphic XX female XY male sex chromosome system. It is commonly accepted that they originated from a pair of autosomes after gaining a sex-determining function, leading to recombination suppression and subsequent Y chromosome degeneration. Unlike eutherian sex chromosomes which share a pseudo-autosomal region (PAR), the marsupial sex chromosomes are typically tiny and lack any homology. However, there is a lack of empirical evidence on biological systems that represent early stages of sex chromosome differentiation. Here, we describe the meiotic dynamics of an XY1Y2 system in the greater bilby (Macrotis lagotis: family Thylacomyidae) that resulted from a fusion between an autosome and the ancestral X chromosome. We compared the similarities and differences in the regulation of meiosis in two other Australian marsupial species with different sex chromosome systems: the tammar wallaby (Macropus eugenii: family Macropodidae) and the fat-tailed dunnart (Sminthopsis crassicaudata: family Dasyuridae), both with the ancestral XY system. We performed a cytological analysis of meiotic prophase I, including the study of chromosome synapsis, double strand break formation (as a proxy of recombination) and meiotic sex chromosome inactivation. Our results suggest that the neo-PAR in the greater bilby represents an early stage of differentiation, providing new insights into sex chromosome evolution. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/321125 https://dx.doi.org/urn:doi:10.3389/fcell.2025.1562403 |
| url |
https://ddd.uab.cat/record/321125 https://dx.doi.org/urn:doi:10.3389/fcell.2025.1562403 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-112557GB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00122 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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