Presentation of cytomegalovirus antigens by non-classical HLA class I molecules
Human cytomegalovirus (HCMV) causes a prevalent lifelong infection in all human populations. Although the course is generally mild and the virus remains latent, HCMV can cause severe disorders in immunocompromised patients and, particularly, in congenital infection. NK cells and T lymphocytes specif...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/688632 |
| Acceso en línea: | http://hdl.handle.net/10803/688632 |
| Access Level: | acceso abierto |
| Palabra clave: | Immunology Cytomegalovirus HLA T lymphocyte NK cell Immunologia Citomegalovirus Limfòcits T Cèl·lules NK Pèptids 576 |
| Sumario: | Human cytomegalovirus (HCMV) causes a prevalent lifelong infection in all human populations. Although the course is generally mild and the virus remains latent, HCMV can cause severe disorders in immunocompromised patients and, particularly, in congenital infection. NK cells and T lymphocytes specific for viral antigens presented by classical HLA-class I (HLA-I) molecules (i.e. HLA-A, -B, -C) play an important role in the control of HCMV infection. Here, we explored the existence of additional viral peptides presented by non-classical HLA class I molecules. |
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