Antimicrobial peptides in the battle against orthopedic implant-related infections: A review

Prevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insufficient, and infection prevalence may rise due to t...

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Autores: Costa, B. (Bruna)|||/items/98c36bca-2538-4887-9a45-5b074a610209, Martinez-de-Tejada, G. (Guillermo)|||/items/d1daba26-b84c-4914-8630-f3a980ec3bc8, Gomes, P.A.C. (Paula A. C.)|||/items/1980a046-3919-4ca7-a397-a6c3e85ef5cd, Martins, M.C.L. (M. Cristina L.)|||/items/64a7137d-5678-463c-b790-784c99b97fe8, Costa, F. (Fabiola)|||/items/bf17d949-89cf-40ce-9480-214b368d9121
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/68497
Acesso em linha:https://hdl.handle.net/10171/68497
Access Level:acceso abierto
Palavra-chave:Antimicrobial
Antimicrobial-peptides (AMPs)
Orthopedic implant-related infections
Peptide immobilization
Peptide release
Surface functionalization
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spelling Antimicrobial peptides in the battle against orthopedic implant-related infections: A reviewCosta, B. (Bruna)|||/items/98c36bca-2538-4887-9a45-5b074a610209Martinez-de-Tejada, G. (Guillermo)|||/items/d1daba26-b84c-4914-8630-f3a980ec3bc8Gomes, P.A.C. (Paula A. C.)|||/items/1980a046-3919-4ca7-a397-a6c3e85ef5cdMartins, M.C.L. (M. Cristina L.)|||/items/64a7137d-5678-463c-b790-784c99b97fe8Costa, F. (Fabiola)|||/items/bf17d949-89cf-40ce-9480-214b368d9121AntimicrobialAntimicrobial-peptides (AMPs)Orthopedic implant-related infectionsPeptide immobilizationPeptide releaseSurface functionalizationPrevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insufficient, and infection prevalence may rise due to the dissemination of antibiotic resistance. Antimicrobial peptides (AMPs) have attracted attention as promising substitutes of conventional antibiotics, owing to their broad-spectrum of activity, high efficacy at very low concentrations, and, importantly, low propensity for inducing resistance. The aim of this review is to offer an updated perspective of the development of AMPs-based preventive strategies for orthopedic and dental implant-related infections. In this regard, two major research strategies are herein addressed, namely (i) AMP-releasing systems from titanium-modified surfaces and from bone cements or beads; and (ii) AMP immobilization strategies used to graft AMPs onto titanium or other model surfaces with potential translation as coatings. In overview, releasing strategies have evolved to guarantee higher loadings, prolonged and targeted delivery periods upon infection. In addition, avant-garde self-assembling strategies or polymer brushes allowed higher immobilized peptide surface densities, overcoming bioavailability issues. Future research efforts should focus on the regulatory demands for pre-clinical and clinical validation towards clinical translation.MDPIDadun. Depósito Académico Digital Universidad de Navarra20242024-01-2320212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/68497reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/684972026-06-21T12:47:57Z
dc.title.none.fl_str_mv Antimicrobial peptides in the battle against orthopedic implant-related infections: A review
title Antimicrobial peptides in the battle against orthopedic implant-related infections: A review
spellingShingle Antimicrobial peptides in the battle against orthopedic implant-related infections: A review
Costa, B. (Bruna)|||/items/98c36bca-2538-4887-9a45-5b074a610209
Antimicrobial
Antimicrobial-peptides (AMPs)
Orthopedic implant-related infections
Peptide immobilization
Peptide release
Surface functionalization
title_short Antimicrobial peptides in the battle against orthopedic implant-related infections: A review
title_full Antimicrobial peptides in the battle against orthopedic implant-related infections: A review
title_fullStr Antimicrobial peptides in the battle against orthopedic implant-related infections: A review
title_full_unstemmed Antimicrobial peptides in the battle against orthopedic implant-related infections: A review
title_sort Antimicrobial peptides in the battle against orthopedic implant-related infections: A review
dc.creator.none.fl_str_mv Costa, B. (Bruna)|||/items/98c36bca-2538-4887-9a45-5b074a610209
Martinez-de-Tejada, G. (Guillermo)|||/items/d1daba26-b84c-4914-8630-f3a980ec3bc8
Gomes, P.A.C. (Paula A. C.)|||/items/1980a046-3919-4ca7-a397-a6c3e85ef5cd
Martins, M.C.L. (M. Cristina L.)|||/items/64a7137d-5678-463c-b790-784c99b97fe8
Costa, F. (Fabiola)|||/items/bf17d949-89cf-40ce-9480-214b368d9121
author Costa, B. (Bruna)|||/items/98c36bca-2538-4887-9a45-5b074a610209
author_facet Costa, B. (Bruna)|||/items/98c36bca-2538-4887-9a45-5b074a610209
Martinez-de-Tejada, G. (Guillermo)|||/items/d1daba26-b84c-4914-8630-f3a980ec3bc8
Gomes, P.A.C. (Paula A. C.)|||/items/1980a046-3919-4ca7-a397-a6c3e85ef5cd
Martins, M.C.L. (M. Cristina L.)|||/items/64a7137d-5678-463c-b790-784c99b97fe8
Costa, F. (Fabiola)|||/items/bf17d949-89cf-40ce-9480-214b368d9121
author_role author
author2 Martinez-de-Tejada, G. (Guillermo)|||/items/d1daba26-b84c-4914-8630-f3a980ec3bc8
Gomes, P.A.C. (Paula A. C.)|||/items/1980a046-3919-4ca7-a397-a6c3e85ef5cd
Martins, M.C.L. (M. Cristina L.)|||/items/64a7137d-5678-463c-b790-784c99b97fe8
Costa, F. (Fabiola)|||/items/bf17d949-89cf-40ce-9480-214b368d9121
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Antimicrobial
Antimicrobial-peptides (AMPs)
Orthopedic implant-related infections
Peptide immobilization
Peptide release
Surface functionalization
topic Antimicrobial
Antimicrobial-peptides (AMPs)
Orthopedic implant-related infections
Peptide immobilization
Peptide release
Surface functionalization
description Prevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insufficient, and infection prevalence may rise due to the dissemination of antibiotic resistance. Antimicrobial peptides (AMPs) have attracted attention as promising substitutes of conventional antibiotics, owing to their broad-spectrum of activity, high efficacy at very low concentrations, and, importantly, low propensity for inducing resistance. The aim of this review is to offer an updated perspective of the development of AMPs-based preventive strategies for orthopedic and dental implant-related infections. In this regard, two major research strategies are herein addressed, namely (i) AMP-releasing systems from titanium-modified surfaces and from bone cements or beads; and (ii) AMP immobilization strategies used to graft AMPs onto titanium or other model surfaces with potential translation as coatings. In overview, releasing strategies have evolved to guarantee higher loadings, prolonged and targeted delivery periods upon infection. In addition, avant-garde self-assembling strategies or polymer brushes allowed higher immobilized peptide surface densities, overcoming bioavailability issues. Future research efforts should focus on the regulatory demands for pre-clinical and clinical validation towards clinical translation.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
2024
2024-01-23
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/68497
url https://hdl.handle.net/10171/68497
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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