Enantioselective Synthesis of Spiro[indolizidine-1,3 '-oxindoles]

A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3'-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic 5-oxoester, bromination of the resulting oxazolopiperidone lactam, and a final stereose...

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Detalhes bibliográficos
Autores: Pérez Bosch, Maria, Ramos, Carlos, Massi, Lucia, Gazzola, Silvia, Taglienti, Chiara, Yayik, Nihan, Molins i Grau, Elies, Viayna Gaza, Antonio, Luque Garriga, F. Xavier, Bosch Cartes, Joan, Amat Tusón, Mercedes
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/167518
Acesso em linha:https://hdl.handle.net/2445/167518
Access Level:acceso abierto
Palavra-chave:Síntesi orgànica
Enantiòmers
Oxidació
Compostos heterocíclics
Organic synthesis
Enantiomers
Oxidation
Heterocyclic compounds
Descrição
Resumo:A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3'-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic 5-oxoester, bromination of the resulting oxazolopiperidone lactam, and a final stereoselective spirocyclization, is reported.

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