Solvent-cast direct-writing as a fabrication strategy for radiopaque stents
Bioresorbable stents (BRS) potential in treating coronary heart disease is still to be further developed. Current trends include research with new polymeric materials, the need for thinner struts combined with appropriate mechanical properties, radiopacity and optimized local drug delivery. This wor...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/360840 |
| Acceso en línea: | https://hdl.handle.net/2117/360840 https://dx.doi.org/10.1016/j.addma.2021.102392 |
| Access Level: | acceso abierto |
| Palabra clave: | Tissue engineering Biomedical materials Biomedical engineering X-Rays Solvent-cast direct-writing Bioresorbable stents Poly-l-lactic acid Radiopacity X-Ray imaging Enginyeria de teixits Materials biomèdics Enginyeria biomèdica Raigs X Àrees temàtiques de la UPC::Enginyeria dels materials |
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Solvent-cast direct-writing as a fabrication strategy for radiopaque stentsChausse Calbet, Victor|||0000-0002-2644-6305Schieber, RomainRaymond Llorens, Santiago|||0000-0001-8302-3002Ségry, BrianSabaté, RamonKolandaivelu, KumaranGinebra Molins, Maria Pau|||0000-0002-4700-5621Pegueroles Neyra, Marta|||0000-0002-7895-8337Tissue engineeringBiomedical materialsBiomedical engineeringX-RaysSolvent-cast direct-writingBioresorbable stentsPoly-l-lactic acidRadiopacityX-Ray imagingEnginyeria de teixitsMaterials biomèdicsEnginyeria biomèdicaRaigs XÀrees temàtiques de la UPC::Enginyeria dels materialsBioresorbable stents (BRS) potential in treating coronary heart disease is still to be further developed. Current trends include research with new polymeric materials, the need for thinner struts combined with appropriate mechanical properties, radiopacity and optimized local drug delivery. This work presents a novel solvent-cast direct-write (SC-DW) printing system to manufacture BRS onto a rotating cylinder with poly-l-lactic acid (PLLA) and poly(l-lactic-co- ¿ -caprolactone) (PLCL) inks. Printed stents were characterized in terms of mechanical, thermal and biological properties with human umbilical vein endothelial cells (HUVECs). Expansion assays showed that stents withstood pressures of at least 16 atm and the indirect cytotoxicity test indicated that stents were biocompatible. Polymeric inks were further modified with the addition of 3 radiopaque agents, namely iodine, triiodobenzoic acid (TIBA) and barium sulfate (BaSO) to render stents radiopaque. Subsequent characterization showed a general increase in strut thickness with respect to control PLLA or PLCL stents, which in turn resulted in higher resistance to compression. Microcomputed tomography was used to assess stents’ radiopacity, showing that TIBA and BaSO-containing stents presented high X-ray attenuation values and maintained their radiopacity after 3 months incubation time.Peer ReviewedElsevier20212021-12-0120222022-01-27journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/360840https://dx.doi.org/10.1016/j.addma.2021.102392reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3608402026-05-27T15:37:01Z |
| dc.title.none.fl_str_mv |
Solvent-cast direct-writing as a fabrication strategy for radiopaque stents |
| title |
Solvent-cast direct-writing as a fabrication strategy for radiopaque stents |
| spellingShingle |
Solvent-cast direct-writing as a fabrication strategy for radiopaque stents Chausse Calbet, Victor|||0000-0002-2644-6305 Tissue engineering Biomedical materials Biomedical engineering X-Rays Solvent-cast direct-writing Bioresorbable stents Poly-l-lactic acid Radiopacity X-Ray imaging Enginyeria de teixits Materials biomèdics Enginyeria biomèdica Raigs X Àrees temàtiques de la UPC::Enginyeria dels materials |
| title_short |
Solvent-cast direct-writing as a fabrication strategy for radiopaque stents |
| title_full |
Solvent-cast direct-writing as a fabrication strategy for radiopaque stents |
| title_fullStr |
Solvent-cast direct-writing as a fabrication strategy for radiopaque stents |
| title_full_unstemmed |
Solvent-cast direct-writing as a fabrication strategy for radiopaque stents |
| title_sort |
Solvent-cast direct-writing as a fabrication strategy for radiopaque stents |
| dc.creator.none.fl_str_mv |
Chausse Calbet, Victor|||0000-0002-2644-6305 Schieber, Romain Raymond Llorens, Santiago|||0000-0001-8302-3002 Ségry, Brian Sabaté, Ramon Kolandaivelu, Kumaran Ginebra Molins, Maria Pau|||0000-0002-4700-5621 Pegueroles Neyra, Marta|||0000-0002-7895-8337 |
| author |
Chausse Calbet, Victor|||0000-0002-2644-6305 |
| author_facet |
Chausse Calbet, Victor|||0000-0002-2644-6305 Schieber, Romain Raymond Llorens, Santiago|||0000-0001-8302-3002 Ségry, Brian Sabaté, Ramon Kolandaivelu, Kumaran Ginebra Molins, Maria Pau|||0000-0002-4700-5621 Pegueroles Neyra, Marta|||0000-0002-7895-8337 |
| author_role |
author |
| author2 |
Schieber, Romain Raymond Llorens, Santiago|||0000-0001-8302-3002 Ségry, Brian Sabaté, Ramon Kolandaivelu, Kumaran Ginebra Molins, Maria Pau|||0000-0002-4700-5621 Pegueroles Neyra, Marta|||0000-0002-7895-8337 |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Tissue engineering Biomedical materials Biomedical engineering X-Rays Solvent-cast direct-writing Bioresorbable stents Poly-l-lactic acid Radiopacity X-Ray imaging Enginyeria de teixits Materials biomèdics Enginyeria biomèdica Raigs X Àrees temàtiques de la UPC::Enginyeria dels materials |
| topic |
Tissue engineering Biomedical materials Biomedical engineering X-Rays Solvent-cast direct-writing Bioresorbable stents Poly-l-lactic acid Radiopacity X-Ray imaging Enginyeria de teixits Materials biomèdics Enginyeria biomèdica Raigs X Àrees temàtiques de la UPC::Enginyeria dels materials |
| description |
Bioresorbable stents (BRS) potential in treating coronary heart disease is still to be further developed. Current trends include research with new polymeric materials, the need for thinner struts combined with appropriate mechanical properties, radiopacity and optimized local drug delivery. This work presents a novel solvent-cast direct-write (SC-DW) printing system to manufacture BRS onto a rotating cylinder with poly-l-lactic acid (PLLA) and poly(l-lactic-co- ¿ -caprolactone) (PLCL) inks. Printed stents were characterized in terms of mechanical, thermal and biological properties with human umbilical vein endothelial cells (HUVECs). Expansion assays showed that stents withstood pressures of at least 16 atm and the indirect cytotoxicity test indicated that stents were biocompatible. Polymeric inks were further modified with the addition of 3 radiopaque agents, namely iodine, triiodobenzoic acid (TIBA) and barium sulfate (BaSO) to render stents radiopaque. Subsequent characterization showed a general increase in strut thickness with respect to control PLLA or PLCL stents, which in turn resulted in higher resistance to compression. Microcomputed tomography was used to assess stents’ radiopacity, showing that TIBA and BaSO-containing stents presented high X-ray attenuation values and maintained their radiopacity after 3 months incubation time. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-12-01 2022 2022-01-27 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2117/360840 https://dx.doi.org/10.1016/j.addma.2021.102392 |
| url |
https://hdl.handle.net/2117/360840 https://dx.doi.org/10.1016/j.addma.2021.102392 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC) |
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Universitat Politècnica de Catalunya (UPC) |
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UPCommons. Portal del coneixement obert de la UPC |
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UPCommons. Portal del coneixement obert de la UPC |
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1869411679551356928 |
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15,300719 |