Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South America
The genus Clinanthus Herb. is found in the Andes Region (South America), mainly in Peru, Ecuador, and Bolivia. These plants belong to the Amaryllidaceae family, specifically the Amaryllidoideae subfamily, which presents an exclusive group of alkaloids known as Amaryllidaceae alkaloids that show impo...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/207863 |
| Acceso en línea: | https://hdl.handle.net/2445/207863 |
| Access Level: | acceso abierto |
| Palabra clave: | Malaltia d'Alzheimer Alcaloides Marcadors bioquímics Alzheimer's disease Alkaloids Biochemical markers |
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Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South AmericaRodríguez-Escobar, María LennyTallini, Luciana R.Lisa-Molina, JuliaBerkov, StrahilViladomat Meya, FrancescMeerow, AlanBastida Armengol, JaumeTorras Claveria, LauraMalaltia d'AlzheimerAlcaloidesMarcadors bioquímicsAlzheimer's diseaseAlkaloidsBiochemical markersThe genus Clinanthus Herb. is found in the Andes Region (South America), mainly in Peru, Ecuador, and Bolivia. These plants belong to the Amaryllidaceae family, specifically the Amaryllidoideae subfamily, which presents an exclusive group of alkaloids known as Amaryllidaceae alkaloids that show important structural diversity and pharmacological properties. It is possible to find some publications in the literature regarding the botanical aspects of Clinanthus species, although there is little information available about their chemical and biological activities. The aim of this work was to obtain the alkaloid profile and the anti-cholinesterase activity of four different samples of Clinanthus collected in South America: Clinanthus sp., Clinanthus incarnatus, and Clinanthus variegatus. The alkaloid extract of each sample was analyzed by gas chromatography coupled with mass spectrometry (GC-MS), and their potential against the enzymes acetyl- and butyrylcholinesterase were evaluated. Thirteen alkaloids have been identified among these species, while six unidentified structures have also been detected in these plants. The alkaloid extract of the C. variegatus samples showed the highest structural diversity as well as the best activity against AChE, which was likely due to the presence of the alkaloid sanguinine. The results suggest this genus as a possible interesting new source of Amaryllidaceae alkaloids, which could contribute to the development of new medicines. Keywords: Alzheimer’s disease; Amaryllidaceae alkaloids; Clinanthus incarnatus; Clinanthus sp.; Clinanthus variegatus; alkaloid profiling.MDPI2024202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1 p.application/pdfhttps://hdl.handle.net/2445/207863Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/doi.org/10.3390/molecules28145408Molecules, 2023, vol. 28, num.5408https://doi.org/doi.org/10.3390/molecules28145408cc-by (c) Rodríguez-Escobar, M.L. et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2078632026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South America |
| title |
Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South America |
| spellingShingle |
Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South America Rodríguez-Escobar, María Lenny Malaltia d'Alzheimer Alcaloides Marcadors bioquímics Alzheimer's disease Alkaloids Biochemical markers |
| title_short |
Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South America |
| title_full |
Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South America |
| title_fullStr |
Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South America |
| title_full_unstemmed |
Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South America |
| title_sort |
Chemical and biological aspects of different species of the genus Clinanthus Herb. (Amaryllidaceae) from South America |
| dc.creator.none.fl_str_mv |
Rodríguez-Escobar, María Lenny Tallini, Luciana R. Lisa-Molina, Julia Berkov, Strahil Viladomat Meya, Francesc Meerow, Alan Bastida Armengol, Jaume Torras Claveria, Laura |
| author |
Rodríguez-Escobar, María Lenny |
| author_facet |
Rodríguez-Escobar, María Lenny Tallini, Luciana R. Lisa-Molina, Julia Berkov, Strahil Viladomat Meya, Francesc Meerow, Alan Bastida Armengol, Jaume Torras Claveria, Laura |
| author_role |
author |
| author2 |
Tallini, Luciana R. Lisa-Molina, Julia Berkov, Strahil Viladomat Meya, Francesc Meerow, Alan Bastida Armengol, Jaume Torras Claveria, Laura |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Malaltia d'Alzheimer Alcaloides Marcadors bioquímics Alzheimer's disease Alkaloids Biochemical markers |
| topic |
Malaltia d'Alzheimer Alcaloides Marcadors bioquímics Alzheimer's disease Alkaloids Biochemical markers |
| description |
The genus Clinanthus Herb. is found in the Andes Region (South America), mainly in Peru, Ecuador, and Bolivia. These plants belong to the Amaryllidaceae family, specifically the Amaryllidoideae subfamily, which presents an exclusive group of alkaloids known as Amaryllidaceae alkaloids that show important structural diversity and pharmacological properties. It is possible to find some publications in the literature regarding the botanical aspects of Clinanthus species, although there is little information available about their chemical and biological activities. The aim of this work was to obtain the alkaloid profile and the anti-cholinesterase activity of four different samples of Clinanthus collected in South America: Clinanthus sp., Clinanthus incarnatus, and Clinanthus variegatus. The alkaloid extract of each sample was analyzed by gas chromatography coupled with mass spectrometry (GC-MS), and their potential against the enzymes acetyl- and butyrylcholinesterase were evaluated. Thirteen alkaloids have been identified among these species, while six unidentified structures have also been detected in these plants. The alkaloid extract of the C. variegatus samples showed the highest structural diversity as well as the best activity against AChE, which was likely due to the presence of the alkaloid sanguinine. The results suggest this genus as a possible interesting new source of Amaryllidaceae alkaloids, which could contribute to the development of new medicines. Keywords: Alzheimer’s disease; Amaryllidaceae alkaloids; Clinanthus incarnatus; Clinanthus sp.; Clinanthus variegatus; alkaloid profiling. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2024 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/207863 |
| url |
https://hdl.handle.net/2445/207863 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/doi.org/10.3390/molecules28145408 Molecules, 2023, vol. 28, num.5408 https://doi.org/doi.org/10.3390/molecules28145408 |
| dc.rights.none.fl_str_mv |
cc-by (c) Rodríguez-Escobar, M.L. et al., 2023 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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cc-by (c) Rodríguez-Escobar, M.L. et al., 2023 http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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1 p. application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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