Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot study

Background: The Global Influenza Hospital Surveillance Network (GIHSN) has operated with the aim of investigating epidemiological and clinical factors related to severe influenza-related hospitalisations. Study design: A common GIHSN core protocol for prospective patient enrolment was implemented. H...

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Authors: Quéromès G, Frobert E, Burtseva E, Draganescu A, Koul PA, Komissarov A, Laguna-Torres VA, Leblanc J, López-Labrador FX, Medic S, Mironenko A, Otieno NA, Ruiz-Palacios GM, Md T, Ngs Team-Lyon, Gihsn Collaborators, Josset L, Lina B
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p13634
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/13634
Access Level:Open access
Keyword:Influenza virus
Surveillance
Epidemiology
Hospitalization
Genome sequencing
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spelling Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot studyQuéromès GFrobert EBurtseva EDraganescu AKoul PAKomissarov ALaguna-Torres VALeblanc JLópez-Labrador FXMedic SMironenko AOtieno NARuiz-Palacios GMMd TNgs Team-LyonGihsn CollaboratorsJosset LLina BInfluenza virusSurveillanceEpidemiologyHospitalizationGenome sequencingBackground: The Global Influenza Hospital Surveillance Network (GIHSN) has operated with the aim of investigating epidemiological and clinical factors related to severe influenza-related hospitalisations. Study design: A common GIHSN core protocol for prospective patient enrolment was implemented. Hospital personnel completed a standardized questionnaire regarding the included patients' medical history, compiled a hospitalisation summary, collected an upper respiratory swab sample for laboratory diagnosis, and genome sequencing was performed for a subset of samples. Patient data were compared according to influenza subtype, lineage, and phylogenetic groups using the Fisher's exact test. Results: From September 2019 to May 2020, 8791 patients aged >= 5 years were included. Among them, 3021 (34.4%) had a laboratory-confirmed influenza diagnosis. Influenza A(H1N1)pdm09 dominated the season among all age groups, while the B/Victoria-like lineage accounted for over half of the infections among younger age groups (5-49 years). Sequencing of the hemagglutinin segment was possible for 623 samples and revealed an influenza A and B clade frequency among severe influenza hospitalisations similar to other medically attended surveillance networks, such as the WHO GISRS. No phylogenetic clustering was observed among hemagglutinin substitutions depending on the administration of supplemental oxygen or vaccine failure. Conclusions: The GIHSN confirms its ability as an international hospital-based active surveillance network to provide valuable information on influenza infection dynamics in hospital settings. Increasing the number of participating sites and compiling more complete data, such as genome sequencing, will allow the exploration of associations between viral factors, vaccine protection, and disease severity.ELSEVIER2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/13634JOURNAL OF CLINICAL VIROLOGYISSN: 13866532ISSNe: 18735967reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p136342026-06-11T12:45:17Z
dc.title.none.fl_str_mv Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot study
title Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot study
spellingShingle Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot study
Quéromès G
Influenza virus
Surveillance
Epidemiology
Hospitalization
Genome sequencing
title_short Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot study
title_full Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot study
title_fullStr Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot study
title_full_unstemmed Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot study
title_sort Clinical and phylogenetic influenza dynamics for the 2019-20 season in the global influenza hospital surveillance network (GIHSN) - Pilot study
dc.creator.none.fl_str_mv Quéromès G
Frobert E
Burtseva E
Draganescu A
Koul PA
Komissarov A
Laguna-Torres VA
Leblanc J
López-Labrador FX
Medic S
Mironenko A
Otieno NA
Ruiz-Palacios GM
Md T
Ngs Team-Lyon
Gihsn Collaborators
Josset L
Lina B
author Quéromès G
author_facet Quéromès G
Frobert E
Burtseva E
Draganescu A
Koul PA
Komissarov A
Laguna-Torres VA
Leblanc J
López-Labrador FX
Medic S
Mironenko A
Otieno NA
Ruiz-Palacios GM
Md T
Ngs Team-Lyon
Gihsn Collaborators
Josset L
Lina B
author_role author
author2 Frobert E
Burtseva E
Draganescu A
Koul PA
Komissarov A
Laguna-Torres VA
Leblanc J
López-Labrador FX
Medic S
Mironenko A
Otieno NA
Ruiz-Palacios GM
Md T
Ngs Team-Lyon
Gihsn Collaborators
Josset L
Lina B
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Influenza virus
Surveillance
Epidemiology
Hospitalization
Genome sequencing
topic Influenza virus
Surveillance
Epidemiology
Hospitalization
Genome sequencing
description Background: The Global Influenza Hospital Surveillance Network (GIHSN) has operated with the aim of investigating epidemiological and clinical factors related to severe influenza-related hospitalisations. Study design: A common GIHSN core protocol for prospective patient enrolment was implemented. Hospital personnel completed a standardized questionnaire regarding the included patients' medical history, compiled a hospitalisation summary, collected an upper respiratory swab sample for laboratory diagnosis, and genome sequencing was performed for a subset of samples. Patient data were compared according to influenza subtype, lineage, and phylogenetic groups using the Fisher's exact test. Results: From September 2019 to May 2020, 8791 patients aged >= 5 years were included. Among them, 3021 (34.4%) had a laboratory-confirmed influenza diagnosis. Influenza A(H1N1)pdm09 dominated the season among all age groups, while the B/Victoria-like lineage accounted for over half of the infections among younger age groups (5-49 years). Sequencing of the hemagglutinin segment was possible for 623 samples and revealed an influenza A and B clade frequency among severe influenza hospitalisations similar to other medically attended surveillance networks, such as the WHO GISRS. No phylogenetic clustering was observed among hemagglutinin substitutions depending on the administration of supplemental oxygen or vaccine failure. Conclusions: The GIHSN confirms its ability as an international hospital-based active surveillance network to provide valuable information on influenza infection dynamics in hospital settings. Increasing the number of participating sites and compiling more complete data, such as genome sequencing, will allow the exploration of associations between viral factors, vaccine protection, and disease severity.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/13634
url https://fisabio.portalinvestigacion.com/publicaciones/13634
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv JOURNAL OF CLINICAL VIROLOGY
ISSN: 13866532
ISSNe: 18735967
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411672397971456
score 15,812429

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