Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA Delivery

Z.W. gratefully acknowledges China Scholarship Council (CSC) for a doctoral scholarship. G.R.-B. acknowledges funding from the Ministerio de Ciencia, Innovación y Universidades through an FPU fellowship (Grant FPU18/02922). Additional support from the ENS Paris-Saclay Booster Program for mobility is...

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Autores: Zhaoxin Wang, Gonzalo Rivero-Barbarroja, Benito, Juan M., Stéphane Maisonneuve, Itziar Vélaz, Inmaculada Juárez-Gonzálvez, María J. Garrido, Conchita Tros de Ilarduya, Carmen Ortiz Mellet, Juan Xie, Jose Manuel García Fernández
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/424073
Acceso en línea:http://hdl.handle.net/10261/424073
Access Level:acceso abierto
Palabra clave:http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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dc.title.none.fl_str_mv Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA Delivery
title Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA Delivery
spellingShingle Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA Delivery
Zhaoxin Wang
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA Delivery
title_full Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA Delivery
title_fullStr Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA Delivery
title_full_unstemmed Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA Delivery
title_sort Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA Delivery
dc.creator.none.fl_str_mv Zhaoxin Wang
Gonzalo Rivero-Barbarroja
Benito, Juan M.
Stéphane Maisonneuve
Itziar Vélaz
Inmaculada Juárez-Gonzálvez
María J. Garrido
Conchita Tros de Ilarduya
Carmen Ortiz Mellet
Juan Xie
Jose Manuel García Fernández
author Zhaoxin Wang
author_facet Zhaoxin Wang
Gonzalo Rivero-Barbarroja
Benito, Juan M.
Stéphane Maisonneuve
Itziar Vélaz
Inmaculada Juárez-Gonzálvez
María J. Garrido
Conchita Tros de Ilarduya
Carmen Ortiz Mellet
Juan Xie
Jose Manuel García Fernández
author_role author
author2 Gonzalo Rivero-Barbarroja
Benito, Juan M.
Stéphane Maisonneuve
Itziar Vélaz
Inmaculada Juárez-Gonzálvez
María J. Garrido
Conchita Tros de Ilarduya
Carmen Ortiz Mellet
Juan Xie
Jose Manuel García Fernández
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
China Scholarship Council
Ministerio de Ciencia, Innovación y Universidades (España)
Université Paris-Saclay
RER-CSIC Biomed
CSIC - Plataforma Temática Interdisciplinar del CSIC Salud Global (PTI Salud Global)
Universidad de Sevilla
Zhaoxin Wang
Gonzalo Rivero-Barbarroja [0000-0002-3124-9373]
Benito, Juan M. [0000-0002-9788-1507]
Stéphane Maisonneuve [0000-0003-0459-3459]
Itziar Velaz [0000-0002-3183-3625]
Inmaculada Juárez-Gonzálvez
María J. Garrido
Conchita Tros de Ilarduya [0000-0001-6414-2719]
Carmen Ortiz Mellet [0000-0002-7676-7721]
Juan Xie [0009-0008-6788-2630]
García Fernández, José M. [0000-0002-6827-0387]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description Z.W. gratefully acknowledges China Scholarship Council (CSC) for a doctoral scholarship. G.R.-B. acknowledges funding from the Ministerio de Ciencia, Innovación y Universidades through an FPU fellowship (Grant FPU18/02922). Additional support from the ENS Paris-Saclay Booster Program for mobility is also acknowledged. J.M.G.F. thanks Red de Enfermedades Raras CSIC (RER-CSIC) and PTI+ Salud Global – CSIC for continuous support. C.O.M. also acknowledge the CITIUS (Univ. Seville), for infrastructural support. The authors would like to thank Dr. Cyril Colas from the “Fédération de Recherche” ICOA/CBM (FR2708) for HRMS analysis. This work was supported by the Ministerio de Ciencia, Innovación y Universidades and the Agencia Estatal de Investigación, AEI/10.130 39/501100011033 and “ERDF A way of making Europe” (PID2021-124247OBC21, PID2021-124247OB-C22, PID2022-141034OB-C21, PID2024-157753OB-C21 and PID2024-157753OB-C22). We also acknowledge funding by the European Union’s Horizon Europe research and innovation program under the Marie Skłodowska-Curie grant agreement 101130235 – Bicyclos
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/424073
url http://hdl.handle.net/10261/424073
dc.language.none.fl_str_mv Inglés
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https://www.nature.com/articles/s42004-026-01920-z
https://doi.org/10.1038/s42004-026-01920-z
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Azobenzene-Bridged Ionizable Amphiphilic Janus Glycosides for Light-Controlled, Single- Component and Organ-Modulable pDNA DeliveryZhaoxin WangGonzalo Rivero-BarbarrojaBenito, Juan M.Stéphane MaisonneuveItziar VélazInmaculada Juárez-GonzálvezMaría J. GarridoConchita Tros de IlarduyaCarmen Ortiz MelletJuan XieJose Manuel García Fernándezhttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesZ.W. gratefully acknowledges China Scholarship Council (CSC) for a doctoral scholarship. G.R.-B. acknowledges funding from the Ministerio de Ciencia, Innovación y Universidades through an FPU fellowship (Grant FPU18/02922). Additional support from the ENS Paris-Saclay Booster Program for mobility is also acknowledged. J.M.G.F. thanks Red de Enfermedades Raras CSIC (RER-CSIC) and PTI+ Salud Global – CSIC for continuous support. C.O.M. also acknowledge the CITIUS (Univ. Seville), for infrastructural support. The authors would like to thank Dr. Cyril Colas from the “Fédération de Recherche” ICOA/CBM (FR2708) for HRMS analysis. This work was supported by the Ministerio de Ciencia, Innovación y Universidades and the Agencia Estatal de Investigación, AEI/10.130 39/501100011033 and “ERDF A way of making Europe” (PID2021-124247OBC21, PID2021-124247OB-C22, PID2022-141034OB-C21, PID2024-157753OB-C21 and PID2024-157753OB-C22). We also acknowledge funding by the European Union’s Horizon Europe research and innovation program under the Marie Skłodowska-Curie grant agreement 101130235 – BicyclosStimuli-responsive supramolecular systems enable spatiotemporal control of nucleic acid (NA) delivery. To achieve precise and programmable vectors, we designed azobenzene-bridged ionizable amphiphilic Janus glycosides (IAJGs) as single-component, light-responsive DNA carriers. These glucopyranose-based dimers undergo reversible E/Z photoisomerization while forming stable nanocomplexes with plasmid DNA (pDNA). Photoisomerization alters nanocomplex size, surface charge, and internal order, resulting in distinct transfection outcomes. In vitro, O- and S-glycoside derivatives displayed isomer-dependent activity across COS-7, HepG2, and RAW264.7 cells, with pronounced switching effects specially in macrophages. In vivo, systemic administration revealed organ-selective responses: O-glycosides shifted expression from liver to lung upon E→Z conversion, whereas S-glycosides favored spleen targeting. All formulations maintained high cell viability. These results highlight photoswitchable IAJGs as structurally defined vectors for adjustable control over NA delivery and organ tropism.Peer reviewedSpringer NatureAgencia Estatal de Investigación (España)China Scholarship CouncilMinisterio de Ciencia, Innovación y Universidades (España)Université Paris-SaclayRER-CSIC BiomedCSIC - Plataforma Temática Interdisciplinar del CSIC Salud Global (PTI Salud Global)Universidad de SevillaZhaoxin WangGonzalo Rivero-Barbarroja [0000-0002-3124-9373]Benito, Juan M. [0000-0002-9788-1507]Stéphane Maisonneuve [0000-0003-0459-3459]Itziar Velaz [0000-0002-3183-3625]Inmaculada Juárez-GonzálvezMaría J. GarridoConchita Tros de Ilarduya [0000-0001-6414-2719]Carmen Ortiz Mellet [0000-0002-7676-7721]Juan Xie [0009-0008-6788-2630]García Fernández, José M. [0000-0002-6827-0387]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262026info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/424073reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124247OB-C22info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-141034OB-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124247OB-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2024-2026/PID2024-157753OB-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2024-2026/PID2024-157753OB-C22info:eu-repo/grantAgreement/EC/HE/101130235-Bicycloshttps://www.nature.com/articles/s42004-026-01920-zhttps://doi.org/10.1038/s42004-026-01920-zSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4240732026-05-22T06:33:51Z
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