Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review

COPD is characterized by a pulmonary and systemic inflammatory process. Several authors have reported the elevation of multiple inflammatory markers in patients with COPD; however, their use in routine clinical practice has limitations. The neutrophil-to-lymphocyte ratio (NLR) is a useful and cost-e...

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Autores: Pascual-González, Yuliana, López Sánchez, Marta, Dorca i Sargatal, Jordi, Santos Pérez, Salud
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172750
Acceso en línea:https://hdl.handle.net/2445/172750
Access Level:acceso abierto
Palabra clave:Malalties pulmonars obstructives cròniques
Mortalitat
Chronic obstructive pulmonary diseases
Mortality
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spelling Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature reviewPascual-González, YulianaLópez Sánchez, MartaDorca i Sargatal, JordiSantos Pérez, SaludMalalties pulmonars obstructives cròniquesMortalitatChronic obstructive pulmonary diseasesMortalityCOPD is characterized by a pulmonary and systemic inflammatory process. Several authors have reported the elevation of multiple inflammatory markers in patients with COPD; however, their use in routine clinical practice has limitations. The neutrophil-to-lymphocyte ratio (NLR) is a useful and cost-effective inflammatory marker derived from routine complete blood count. We performed a systematic literature review using the PRISMA statement. Twenty-two articles were included, recruiting 7,601 COPD patients and 784 healthy controls. Compared with controls, COPD patients had significantly higher NLR values. We found a significant correlation between the NLR and clinical/functional parameters (FEV1, mMRC, and BODE index) in COPD patients. Elevation of the NLR is associated with the diagnosis of acute exacerbation of COPD (pooled data propose a cut-off value of 3.34 with a median sensitivity, specificity, and area under the curve of 80%, 86%, and 0.86, respectively). Additionally, increased NLR is also associated with the diagnosis of a bacterial infection in exacerbated patients, with a cut-off value of 7.30, although with a low sensitivity and specificity. The NLR is an independent predictor of in-hospital and late mortality after exacerbation. In conclusion, the NLR could be a useful marker in COPD patients; however, further studies are needed to better identify the clinical value of the NLR.Dove Medical Press Ltd.2020202020182020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/172750Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.2147/COPD.S178068International Journal of Chronic Obstructive Pulmonary Disease, 2018, vol. 13, p. 3651-3662https://doi.org/10.2147/COPD.S178068cc by-nc (c) Pascual-González et al., 2018http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1727502026-05-29T05:05:01Z
dc.title.none.fl_str_mv Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review
title Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review
spellingShingle Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review
Pascual-González, Yuliana
Malalties pulmonars obstructives cròniques
Mortalitat
Chronic obstructive pulmonary diseases
Mortality
title_short Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review
title_full Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review
title_fullStr Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review
title_full_unstemmed Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review
title_sort Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review
dc.creator.none.fl_str_mv Pascual-González, Yuliana
López Sánchez, Marta
Dorca i Sargatal, Jordi
Santos Pérez, Salud
author Pascual-González, Yuliana
author_facet Pascual-González, Yuliana
López Sánchez, Marta
Dorca i Sargatal, Jordi
Santos Pérez, Salud
author_role author
author2 López Sánchez, Marta
Dorca i Sargatal, Jordi
Santos Pérez, Salud
author2_role author
author
author
dc.subject.none.fl_str_mv Malalties pulmonars obstructives cròniques
Mortalitat
Chronic obstructive pulmonary diseases
Mortality
topic Malalties pulmonars obstructives cròniques
Mortalitat
Chronic obstructive pulmonary diseases
Mortality
description COPD is characterized by a pulmonary and systemic inflammatory process. Several authors have reported the elevation of multiple inflammatory markers in patients with COPD; however, their use in routine clinical practice has limitations. The neutrophil-to-lymphocyte ratio (NLR) is a useful and cost-effective inflammatory marker derived from routine complete blood count. We performed a systematic literature review using the PRISMA statement. Twenty-two articles were included, recruiting 7,601 COPD patients and 784 healthy controls. Compared with controls, COPD patients had significantly higher NLR values. We found a significant correlation between the NLR and clinical/functional parameters (FEV1, mMRC, and BODE index) in COPD patients. Elevation of the NLR is associated with the diagnosis of acute exacerbation of COPD (pooled data propose a cut-off value of 3.34 with a median sensitivity, specificity, and area under the curve of 80%, 86%, and 0.86, respectively). Additionally, increased NLR is also associated with the diagnosis of a bacterial infection in exacerbated patients, with a cut-off value of 7.30, although with a low sensitivity and specificity. The NLR is an independent predictor of in-hospital and late mortality after exacerbation. In conclusion, the NLR could be a useful marker in COPD patients; however, further studies are needed to better identify the clinical value of the NLR.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172750
url https://hdl.handle.net/2445/172750
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2147/COPD.S178068
International Journal of Chronic Obstructive Pulmonary Disease, 2018, vol. 13, p. 3651-3662
https://doi.org/10.2147/COPD.S178068
dc.rights.none.fl_str_mv cc by-nc (c) Pascual-González et al., 2018
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Pascual-González et al., 2018
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press Ltd.
publisher.none.fl_str_mv Dove Medical Press Ltd.
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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