Control of Immunoregulatory Molecules by miRNAs in T Cell Activation
MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/6532 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/6532 |
| Access Level: | acceso abierto |
| Palabra clave: | T cell activation MicroRNAs (miRNAs) Immunoregulatory molecules miRNA signature CD4 CD8 T lymphocyte EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS SYSTEMIC-LUPUS-ERYTHEMATOSUS MICRORNA-MEDIATED REGULATION IMMUNE-RESPONSE TGF-BETA MULTIPLE-SCLEROSIS RNA-INTERFERENCE GENE-EXPRESSION DOWN-REGULATION CYTOKINE PRODUCTION |
| Sumario: | MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules. |
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