Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats

Timing is essential for survival and reproduction of organisms across the tree of life. The core circadian clock gene Clk is involved in the regulation of annual timing events and shows highly conserved sequence homology across vertebrates except for one variable region of poly-glutamine repeats. Cl...

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Autores: Justen, Hannah, Hasselmann, Timo, Illera, Juan Carlos, Delmore, Kira E., Serrano, David, Flinks, Heiner, Senzaki, Masayuki, Kawamura, Kazuhiro, Helm, Barbara, Liedvogel, Miriam
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/279477
Acesso em linha:http://hdl.handle.net/10261/279477
Access Level:Acceso aberto
Palavra-chave:Ecology
Evolution
Genetics
Molecular biology
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spelling Population-specific association of Clock gene polymorphism with annual cycle timing in stonechatsJusten, HannahHasselmann, TimoIllera, Juan CarlosDelmore, Kira E.Serrano, DavidFlinks, HeinerSenzaki, MasayukiKawamura, KazuhiroHelm, BarbaraLiedvogel, MiriamEcologyEvolutionGeneticsMolecular biologyTiming is essential for survival and reproduction of organisms across the tree of life. The core circadian clock gene Clk is involved in the regulation of annual timing events and shows highly conserved sequence homology across vertebrates except for one variable region of poly-glutamine repeats. Clk genotype varies in some species with latitude, seasonal timing and migration. However, findings are inconsistent, difficult to disentangle from environmental responses, and biased towards high latitudes. Here we combine field data with a common-garden experiment to study associations of Clk polymorphism with latitude, migration and annual-cycle timing within the stonechat species complex across its trans-equatorial distribution range. Our dataset includes 950 records from 717 individuals from nine populations with diverse migratory strategies. Gene diversity was lowest in resident African and Canary Island populations and increased with latitude, independently of migration distance. Repeat length and annual-cycle timing was linked in a population-specific way. Specifically, equatorial African stonechats showed delayed timing with longer repeat length for all annual-cycle stages. Our data suggest that at low latitudes with nearly constant photoperiod, Clk genotype might orchestrate a range of consistent, individual chronotypes. In contrast, the influence of Clk on annual-cycle timing at higher latitudes might be mediated by its interactions with genes involved in (circadian) photoperiodic pathways.We thank the Max Planck Society (MPRG grant MFFALIMN0001 to ML), the DFG (Project Z02 within SFB 1372—Magnetoreception and Navigation in Vertebrates to ML), and Eberhard Gwinner, whose previous work on the stonechats and the avian clock forms the basis for this study.Nature Publishing GroupMax Planck SocietyConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/279477reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://doi.org/10.1038/s41598-022-11158-zSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2794772026-05-22T06:33:51Z
dc.title.none.fl_str_mv Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats
title Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats
spellingShingle Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats
Justen, Hannah
Ecology
Evolution
Genetics
Molecular biology
title_short Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats
title_full Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats
title_fullStr Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats
title_full_unstemmed Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats
title_sort Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats
dc.creator.none.fl_str_mv Justen, Hannah
Hasselmann, Timo
Illera, Juan Carlos
Delmore, Kira E.
Serrano, David
Flinks, Heiner
Senzaki, Masayuki
Kawamura, Kazuhiro
Helm, Barbara
Liedvogel, Miriam
author Justen, Hannah
author_facet Justen, Hannah
Hasselmann, Timo
Illera, Juan Carlos
Delmore, Kira E.
Serrano, David
Flinks, Heiner
Senzaki, Masayuki
Kawamura, Kazuhiro
Helm, Barbara
Liedvogel, Miriam
author_role author
author2 Hasselmann, Timo
Illera, Juan Carlos
Delmore, Kira E.
Serrano, David
Flinks, Heiner
Senzaki, Masayuki
Kawamura, Kazuhiro
Helm, Barbara
Liedvogel, Miriam
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Max Planck Society
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ecology
Evolution
Genetics
Molecular biology
topic Ecology
Evolution
Genetics
Molecular biology
description Timing is essential for survival and reproduction of organisms across the tree of life. The core circadian clock gene Clk is involved in the regulation of annual timing events and shows highly conserved sequence homology across vertebrates except for one variable region of poly-glutamine repeats. Clk genotype varies in some species with latitude, seasonal timing and migration. However, findings are inconsistent, difficult to disentangle from environmental responses, and biased towards high latitudes. Here we combine field data with a common-garden experiment to study associations of Clk polymorphism with latitude, migration and annual-cycle timing within the stonechat species complex across its trans-equatorial distribution range. Our dataset includes 950 records from 717 individuals from nine populations with diverse migratory strategies. Gene diversity was lowest in resident African and Canary Island populations and increased with latitude, independently of migration distance. Repeat length and annual-cycle timing was linked in a population-specific way. Specifically, equatorial African stonechats showed delayed timing with longer repeat length for all annual-cycle stages. Our data suggest that at low latitudes with nearly constant photoperiod, Clk genotype might orchestrate a range of consistent, individual chronotypes. In contrast, the influence of Clk on annual-cycle timing at higher latitudes might be mediated by its interactions with genes involved in (circadian) photoperiodic pathways.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/279477
url http://hdl.handle.net/10261/279477
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://doi.org/10.1038/s41598-022-11158-z
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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