Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseases

Synsepalum dulcificum (Richardella dulcifica) is a berry fruit from West Africa with the ability to convert the sour taste into a sweet taste, and for this reason, the fruit is also known as the “miracle berry” (MB). The red and bright berry is rich in terpenoids. The fruit’s pulp and skin contain m...

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Detalles Bibliográficos
Autores: Wagner, Sonia, Gómez de Cedrón, Marta, Navarro del Hierro, Joaquín, Martín Hernández, Diego, Siles Sánchez, María de las Nieves, Santoyo Díez, Susana, Jaime de Pablo, Laura, Martín García, Diana, Fornari Reale, Tiziana, Ramírez de Molina, Ana
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/707704
Acceso en línea:http://hdl.handle.net/10486/707704
https://dx.doi.org/10.3390/ijms24086957
Access Level:acceso abierto
Palabra clave:Taste Buds
Type 2 Taste Receptors
Guanine Nucleotide Binding Protein
Ciencia y Tecnología de Alimentos
Química
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spelling Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseasesWagner, SoniaGómez de Cedrón, MartaNavarro del Hierro, JoaquínMartín Hernández, DiegoSiles Sánchez, María de las NievesSantoyo Díez, SusanaJaime de Pablo, LauraMartín García, DianaFornari Reale, TizianaRamírez de Molina, AnaTaste BudsType 2 Taste ReceptorsGuanine Nucleotide Binding ProteinCiencia y Tecnología de AlimentosQuímicaSynsepalum dulcificum (Richardella dulcifica) is a berry fruit from West Africa with the ability to convert the sour taste into a sweet taste, and for this reason, the fruit is also known as the “miracle berry” (MB). The red and bright berry is rich in terpenoids. The fruit’s pulp and skin contain mainly phenolic compounds and flavonoids, which correlate with their antioxidant activity. Different polar extracts have been described to inhibit cell proliferation and transformation of cancer cell lines in vitro. In addition, MB has been shown to ameliorate insulin resistance in a preclinical model of diabetes induced by a chow diet enriched in fructose. Herein, we have compared the biological activities of three supercritical extracts obtained from the seed—a subproduct of the fruit—and one supercritical extract obtained from the pulp and the skin of MB. The four extracts have been characterized in terms of total polyphenols content. Moreover, the antioxidant, anti-inflammatory, hypo-lipidemic, and inhibition of colorectal cancer cell bioenergetics have been compared. Non-polar supercritical extracts from the seed are the ones with the highest effects on the inhibition of bioenergetic of colorectal (CRC) cancer cells. At the molecular level, the effects on cell bioenergetics seems to be related to the inhibition of main drivers of the de novo lipogenesis, such as the sterol regulatory element binding transcription factor (SREBF1) and downstream molecular targets fatty acid synthase (FASN) and stearoyl coenzyme desaturase 1 (SCD1). As metabolic reprograming is considered as one of the hallmarks of cancer, natural extracts from plants may provide complementary approaches in the treatment of cancer. Herein, for the first time, supercritical extracts from MB have been obtained, where the seed, a by-product of the fruit, seems to be rich in antitumor bioactive compounds. Based on these results, supercritical extracts from the seed merit further research to be proposed as co-adjuvants in the treatment of cancerThis research was funded by Regional Government of Community of Madrid (IND2018/BIO10097; P2018/BAA-4343-ALIBIRD2020-CM), Ministerio de Ciencia e Innovación, Spain (PID2019- 110183RB-C21); Spanish Government (Project: PID2019-110183RB-C22/AEI/10.13039/501100011033); Ramon Areces Foundation (CIVP19A5937); EU Structural Funds and COST Action (CA17118); Synergistic Projects Community of Madrid (NUTRISION-CM/Y2020/BIO-6350), and REACT EU Program (Comunidad de Madrid and The European Regional Development Fund). Sonia Wagner has a predoctoral grant from the industrial predoctoral program of Community of Madrid (IND2018/BIO-10097)MDPIDepartamento de Química Física AplicadaFacultad de Ciencias20232023-04-02research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/707704https://dx.doi.org/10.3390/ijms24086957reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7077042026-06-23T12:46:27Z
dc.title.none.fl_str_mv Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseases
title Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseases
spellingShingle Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseases
Wagner, Sonia
Taste Buds
Type 2 Taste Receptors
Guanine Nucleotide Binding Protein
Ciencia y Tecnología de Alimentos
Química
title_short Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseases
title_full Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseases
title_fullStr Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseases
title_full_unstemmed Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseases
title_sort Biological activities of miracle berry supercritical extracts as metabolic regulators in chronic diseases
dc.creator.none.fl_str_mv Wagner, Sonia
Gómez de Cedrón, Marta
Navarro del Hierro, Joaquín
Martín Hernández, Diego
Siles Sánchez, María de las Nieves
Santoyo Díez, Susana
Jaime de Pablo, Laura
Martín García, Diana
Fornari Reale, Tiziana
Ramírez de Molina, Ana
author Wagner, Sonia
author_facet Wagner, Sonia
Gómez de Cedrón, Marta
Navarro del Hierro, Joaquín
Martín Hernández, Diego
Siles Sánchez, María de las Nieves
Santoyo Díez, Susana
Jaime de Pablo, Laura
Martín García, Diana
Fornari Reale, Tiziana
Ramírez de Molina, Ana
author_role author
author2 Gómez de Cedrón, Marta
Navarro del Hierro, Joaquín
Martín Hernández, Diego
Siles Sánchez, María de las Nieves
Santoyo Díez, Susana
Jaime de Pablo, Laura
Martín García, Diana
Fornari Reale, Tiziana
Ramírez de Molina, Ana
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Química Física Aplicada
Facultad de Ciencias
dc.subject.none.fl_str_mv Taste Buds
Type 2 Taste Receptors
Guanine Nucleotide Binding Protein
Ciencia y Tecnología de Alimentos
Química
topic Taste Buds
Type 2 Taste Receptors
Guanine Nucleotide Binding Protein
Ciencia y Tecnología de Alimentos
Química
description Synsepalum dulcificum (Richardella dulcifica) is a berry fruit from West Africa with the ability to convert the sour taste into a sweet taste, and for this reason, the fruit is also known as the “miracle berry” (MB). The red and bright berry is rich in terpenoids. The fruit’s pulp and skin contain mainly phenolic compounds and flavonoids, which correlate with their antioxidant activity. Different polar extracts have been described to inhibit cell proliferation and transformation of cancer cell lines in vitro. In addition, MB has been shown to ameliorate insulin resistance in a preclinical model of diabetes induced by a chow diet enriched in fructose. Herein, we have compared the biological activities of three supercritical extracts obtained from the seed—a subproduct of the fruit—and one supercritical extract obtained from the pulp and the skin of MB. The four extracts have been characterized in terms of total polyphenols content. Moreover, the antioxidant, anti-inflammatory, hypo-lipidemic, and inhibition of colorectal cancer cell bioenergetics have been compared. Non-polar supercritical extracts from the seed are the ones with the highest effects on the inhibition of bioenergetic of colorectal (CRC) cancer cells. At the molecular level, the effects on cell bioenergetics seems to be related to the inhibition of main drivers of the de novo lipogenesis, such as the sterol regulatory element binding transcription factor (SREBF1) and downstream molecular targets fatty acid synthase (FASN) and stearoyl coenzyme desaturase 1 (SCD1). As metabolic reprograming is considered as one of the hallmarks of cancer, natural extracts from plants may provide complementary approaches in the treatment of cancer. Herein, for the first time, supercritical extracts from MB have been obtained, where the seed, a by-product of the fruit, seems to be rich in antitumor bioactive compounds. Based on these results, supercritical extracts from the seed merit further research to be proposed as co-adjuvants in the treatment of cancer
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-04-02
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/707704
https://dx.doi.org/10.3390/ijms24086957
url http://hdl.handle.net/10486/707704
https://dx.doi.org/10.3390/ijms24086957
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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