Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats

We have previously shown that the Andalusian-cultivated Asparagus officinalis L. “triguero” variety produces hypocholesterolemic and hepatoprotective effects on rats. This asparagus is a rich source of phytochemicals although we hypothesized there would be some of them more involved in these functio...

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Autores: Vázquez Castilla, Sara, Puerta Vázquez, Rocío de la, García Giménez, María Dolores, Guillén Bejarano, Rafael, Fernández Arche, María de los Ángeles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/38802
Acceso en línea:http://hdl.handle.net/11441/38802
https://doi.org/10.3390/ijms141121227
Access Level:acceso abierto
Palabra clave:Flavonoids
Fibers
Saponins
Rats
“Triguero” asparagus
Diet-induced hypercholesterolemia
Plasma lipids
Hepatic antioxidant enzymes
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spelling Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic ratsVázquez Castilla, SaraPuerta Vázquez, Rocío de laGarcía Giménez, María DoloresGuillén Bejarano, RafaelFernández Arche, María de los ÁngelesFlavonoidsFibersSaponinsRats“Triguero” asparagusDiet-induced hypercholesterolemiaPlasma lipidsHepatic antioxidant enzymesWe have previously shown that the Andalusian-cultivated Asparagus officinalis L. “triguero” variety produces hypocholesterolemic and hepatoprotective effects on rats. This asparagus is a rich source of phytochemicals although we hypothesized there would be some of them more involved in these functional properties. Thus, we aimed to study the effects of asparagus (500 mg/kg body weight (bw)/day) and their partially purified fractions in flavonoids (50 mg/kg bw/day), saponins (5 mg/kg bw/day) and dietary fiber (500 mg/kg bw/day) on oxidative status and on lipid profile in rats fed a cholesterol-rich diet. After 5 weeks treatment, plasma lipid values, hepatic enzyme activities and liver malondialdehyde (MDA) concentrations were measured. With the exception of the saponin fraction (SF), the administration of lyophilized asparagus (LA), fiber fraction (FF), and flavonoid fraction (FVF) to hypercholesterolemic rats produced a significant hypolipidemic effect compare to a high-cholesterol diet (HCD). In addition, the LA and FVF groups exhibited a significant increase in enzyme activity from multiple hepatic antioxidant systems including: superoxide dismutase, catalase, and gluthatione reductase/peroxidase as well as a decrease in MDA concentrations compared to HCD group. These results demonstrate that “triguero” asparagus possesses bioactive constituents, especially dietary fiber and flavonoids, that improve the plasma lipid profile and prevent hepatic oxidative damage under conditions of hypercholesterolemia.Multidisciplinary Digital Publishing Institute (MDPI)Farmacología2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/11441/38802https://doi.org/10.3390/ijms141121227reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Molecular Sciences, 14, 21227-2123910.3390/ijms141121227info:eu-repo/semantics/openAccessoai:idus.us.es:11441/388022026-06-17T12:51:07Z
dc.title.none.fl_str_mv Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats
title Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats
spellingShingle Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats
Vázquez Castilla, Sara
Flavonoids
Fibers
Saponins
Rats
“Triguero” asparagus
Diet-induced hypercholesterolemia
Plasma lipids
Hepatic antioxidant enzymes
title_short Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats
title_full Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats
title_fullStr Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats
title_full_unstemmed Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats
title_sort Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats
dc.creator.none.fl_str_mv Vázquez Castilla, Sara
Puerta Vázquez, Rocío de la
García Giménez, María Dolores
Guillén Bejarano, Rafael
Fernández Arche, María de los Ángeles
author Vázquez Castilla, Sara
author_facet Vázquez Castilla, Sara
Puerta Vázquez, Rocío de la
García Giménez, María Dolores
Guillén Bejarano, Rafael
Fernández Arche, María de los Ángeles
author_role author
author2 Puerta Vázquez, Rocío de la
García Giménez, María Dolores
Guillén Bejarano, Rafael
Fernández Arche, María de los Ángeles
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Farmacología
dc.subject.none.fl_str_mv Flavonoids
Fibers
Saponins
Rats
“Triguero” asparagus
Diet-induced hypercholesterolemia
Plasma lipids
Hepatic antioxidant enzymes
topic Flavonoids
Fibers
Saponins
Rats
“Triguero” asparagus
Diet-induced hypercholesterolemia
Plasma lipids
Hepatic antioxidant enzymes
description We have previously shown that the Andalusian-cultivated Asparagus officinalis L. “triguero” variety produces hypocholesterolemic and hepatoprotective effects on rats. This asparagus is a rich source of phytochemicals although we hypothesized there would be some of them more involved in these functional properties. Thus, we aimed to study the effects of asparagus (500 mg/kg body weight (bw)/day) and their partially purified fractions in flavonoids (50 mg/kg bw/day), saponins (5 mg/kg bw/day) and dietary fiber (500 mg/kg bw/day) on oxidative status and on lipid profile in rats fed a cholesterol-rich diet. After 5 weeks treatment, plasma lipid values, hepatic enzyme activities and liver malondialdehyde (MDA) concentrations were measured. With the exception of the saponin fraction (SF), the administration of lyophilized asparagus (LA), fiber fraction (FF), and flavonoid fraction (FVF) to hypercholesterolemic rats produced a significant hypolipidemic effect compare to a high-cholesterol diet (HCD). In addition, the LA and FVF groups exhibited a significant increase in enzyme activity from multiple hepatic antioxidant systems including: superoxide dismutase, catalase, and gluthatione reductase/peroxidase as well as a decrease in MDA concentrations compared to HCD group. These results demonstrate that “triguero” asparagus possesses bioactive constituents, especially dietary fiber and flavonoids, that improve the plasma lipid profile and prevent hepatic oxidative damage under conditions of hypercholesterolemia.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11441/38802
https://doi.org/10.3390/ijms141121227
url http://hdl.handle.net/11441/38802
https://doi.org/10.3390/ijms141121227
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences, 14, 21227-21239
10.3390/ijms141121227
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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