Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors

Background: Recent data suggest that retinol-binding protein 4 (RBP4) gene variants could be associated with a risk of obesity and its co-morbidities, such as metabolic syndrome, which increases the risk of developing type 2 diabetes mellitus and cardiovascular disease. Objectives: The present study...

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Autores: Codoner-Franch, P, Carrasco-Luna, J, Allepuz, P, Codoner-Alejos, A, Guillem, V
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p3490
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/3490
Access Level:acceso abierto
Palabra clave:C-reactive protein
gene polymorphisms
lipids
obesity
RBP4
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spelling Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factorsCodoner-Franch, PCarrasco-Luna, JAllepuz, PCodoner-Alejos, AGuillem, VC-reactive proteingene polymorphismslipidsobesityRBP4Background: Recent data suggest that retinol-binding protein 4 (RBP4) gene variants could be associated with a risk of obesity and its co-morbidities, such as metabolic syndrome, which increases the risk of developing type 2 diabetes mellitus and cardiovascular disease. Objectives: The present study examined the potential association of RBP4 single nucleotide polymorphisms (SNPs) with childhood obesity and its metabolic complications. Methods: Four RBP4 SNPs, rs3758538 (3944A>C), rs3758539 (4406G>A), rs12265684 (12177G>C) and rs34571439 (14684T>G), were genotyped in a population of 180 Spanish Caucasian children (97 obese and 83 normal-weight children). Association of RBP4 SNPs with obesity, metabolic risk factors (blood pressure, triglycerides, high-density lipoprotein cholesterol, insulin resistance) and markers of vascular inflammation, such as high-sensitive C-reactive protein (hs-CRP), was tested. Results: We found SNP rs3758538 to be associated with obesity (p = 0.007). Specifically, each copy of the minor allele C was associated with an increased risk of obesity, by more than twofold, in respect of being homozygous for the major allele A (odds ratio = 2.4; 95% confidence interval = 1.2-4.8). The rs3758538 and rs34571439 RBP4 SNPs correlated with plasma RBP4 levels. The SNPs rs12265684 and rs34571439 correlated with plasma triglyceride levels. The rs34571439 was also associated to hs-CRP levels. Marginal association of RBP4 SNPs with plasma high-density lipoprotein levels (rs34571439), blood pressure (rs12265684) and insulin resistance (rs3758539) was also observed. Conclusions: These findings suggest that childhood obesity may be associated with variations in RBP4 gene. The presence of selective SNPs in the RBP4 gene may account for metabolic complications.WILEY2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/3490PEDIATRIC DIABETESISSN: 1399543XISSNe: 13995448reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p34902026-06-07T16:35:31Z
dc.title.none.fl_str_mv Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
title Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
spellingShingle Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
Codoner-Franch, P
C-reactive protein
gene polymorphisms
lipids
obesity
RBP4
title_short Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
title_full Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
title_fullStr Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
title_full_unstemmed Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
title_sort Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors
dc.creator.none.fl_str_mv Codoner-Franch, P
Carrasco-Luna, J
Allepuz, P
Codoner-Alejos, A
Guillem, V
author Codoner-Franch, P
author_facet Codoner-Franch, P
Carrasco-Luna, J
Allepuz, P
Codoner-Alejos, A
Guillem, V
author_role author
author2 Carrasco-Luna, J
Allepuz, P
Codoner-Alejos, A
Guillem, V
author2_role author
author
author
author
dc.subject.none.fl_str_mv C-reactive protein
gene polymorphisms
lipids
obesity
RBP4
topic C-reactive protein
gene polymorphisms
lipids
obesity
RBP4
description Background: Recent data suggest that retinol-binding protein 4 (RBP4) gene variants could be associated with a risk of obesity and its co-morbidities, such as metabolic syndrome, which increases the risk of developing type 2 diabetes mellitus and cardiovascular disease. Objectives: The present study examined the potential association of RBP4 single nucleotide polymorphisms (SNPs) with childhood obesity and its metabolic complications. Methods: Four RBP4 SNPs, rs3758538 (3944A>C), rs3758539 (4406G>A), rs12265684 (12177G>C) and rs34571439 (14684T>G), were genotyped in a population of 180 Spanish Caucasian children (97 obese and 83 normal-weight children). Association of RBP4 SNPs with obesity, metabolic risk factors (blood pressure, triglycerides, high-density lipoprotein cholesterol, insulin resistance) and markers of vascular inflammation, such as high-sensitive C-reactive protein (hs-CRP), was tested. Results: We found SNP rs3758538 to be associated with obesity (p = 0.007). Specifically, each copy of the minor allele C was associated with an increased risk of obesity, by more than twofold, in respect of being homozygous for the major allele A (odds ratio = 2.4; 95% confidence interval = 1.2-4.8). The rs3758538 and rs34571439 RBP4 SNPs correlated with plasma RBP4 levels. The SNPs rs12265684 and rs34571439 correlated with plasma triglyceride levels. The rs34571439 was also associated to hs-CRP levels. Marginal association of RBP4 SNPs with plasma high-density lipoprotein levels (rs34571439), blood pressure (rs12265684) and insulin resistance (rs3758539) was also observed. Conclusions: These findings suggest that childhood obesity may be associated with variations in RBP4 gene. The presence of selective SNPs in the RBP4 gene may account for metabolic complications.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/3490
url https://incliva.portalinvestigacion.com/publicaciones/3490
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv PEDIATRIC DIABETES
ISSN: 1399543X
ISSNe: 13995448
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
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