Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi

For a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), have been studied. In recent years, the thymic phenotype o...

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Detalles Bibliográficos
Autores: Muñoz, Juan José, García Ceca Hernández, Javier, Montero Herradón, Sara, Sánchez del Collado, Beatriz, Alfaro Sánchez, David, Zapata González, Agustín
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/12126
Acceso en línea:https://hdl.handle.net/20.500.14352/12126
Access Level:acceso abierto
Palabra clave:611.438
577.27
Thymus
Thymocytes
Thymic epithelial cells
Eph
Ephrins
Inmunología
Biología celular (Biología)
2412 Inmunología
2407 Biología Celular
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oai_identifier_str oai:docta.ucm.es:20.500.14352/12126
network_acronym_str ES
network_name_str España
repository_id_str
spelling Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient ThymiMuñoz, Juan JoséGarcía Ceca Hernández, JavierMontero Herradón, SaraSánchez del Collado, BeatrizAlfaro Sánchez, DavidZapata González, Agustín611.438577.27ThymusThymocytesThymic epithelial cellsEphEphrinsInmunologíaBiología celular (Biología)2412 Inmunología2407 Biología CelularFor a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), have been studied. In recent years, the thymic phenotype of mutant mice deficient in several Ephs and ephrins B has been determined. Remarkably, thymic stroma in these animals exhibits important defects that appear early in ontogeny but little alterations in the proportions of distinct lymphoid cell populations. In the present manuscript, we summarize and extend these results discussing possible mechanisms governing phenotypical and functional thymocyte maturation in an absence of the critical T–TEC interactions, concluding that some signaling mediated by key molecules, such as MHCII, CD80, β5t, Aire, etc. could be sufficient to enable a proper maturation of thymocytes, independently of morphological alterations affecting thymic epitheliumFrontiers MediaUniversidad Complutense de Madrid20182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/12126reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/121262026-06-02T12:44:21Z
dc.title.none.fl_str_mv Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi
title Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi
spellingShingle Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi
Muñoz, Juan José
611.438
577.27
Thymus
Thymocytes
Thymic epithelial cells
Eph
Ephrins
Inmunología
Biología celular (Biología)
2412 Inmunología
2407 Biología Celular
title_short Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi
title_full Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi
title_fullStr Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi
title_full_unstemmed Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi
title_sort Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi
dc.creator.none.fl_str_mv Muñoz, Juan José
García Ceca Hernández, Javier
Montero Herradón, Sara
Sánchez del Collado, Beatriz
Alfaro Sánchez, David
Zapata González, Agustín
author Muñoz, Juan José
author_facet Muñoz, Juan José
García Ceca Hernández, Javier
Montero Herradón, Sara
Sánchez del Collado, Beatriz
Alfaro Sánchez, David
Zapata González, Agustín
author_role author
author2 García Ceca Hernández, Javier
Montero Herradón, Sara
Sánchez del Collado, Beatriz
Alfaro Sánchez, David
Zapata González, Agustín
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 611.438
577.27
Thymus
Thymocytes
Thymic epithelial cells
Eph
Ephrins
Inmunología
Biología celular (Biología)
2412 Inmunología
2407 Biología Celular
topic 611.438
577.27
Thymus
Thymocytes
Thymic epithelial cells
Eph
Ephrins
Inmunología
Biología celular (Biología)
2412 Inmunología
2407 Biología Celular
description For a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), have been studied. In recent years, the thymic phenotype of mutant mice deficient in several Ephs and ephrins B has been determined. Remarkably, thymic stroma in these animals exhibits important defects that appear early in ontogeny but little alterations in the proportions of distinct lymphoid cell populations. In the present manuscript, we summarize and extend these results discussing possible mechanisms governing phenotypical and functional thymocyte maturation in an absence of the critical T–TEC interactions, concluding that some signaling mediated by key molecules, such as MHCII, CD80, β5t, Aire, etc. could be sufficient to enable a proper maturation of thymocytes, independently of morphological alterations affecting thymic epithelium
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/12126
url https://hdl.handle.net/20.500.14352/12126
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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