The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death

33 p.-6 fig.-1 tab.

Detalles Bibliográficos
Autores: Legarda-Ceballos, Ana L., Rojas-Caraballo, Jose, López-Abán, Julio, Ruano, A. L., Yepes, Edward, Gajate, Consuelo, Mollinedo, Faustino, Muro, Antonio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/137211
Acceso en línea:http://hdl.handle.net/10261/137211
Access Level:acceso abierto
Palabra clave:Strongyloidiasis
Alkylphospholipid
Edelfosine
Apoptosis
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spelling The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell deathLegarda-Ceballos, Ana L.Rojas-Caraballo, JoseLópez-Abán, JulioRuano, A. L.Yepes, EdwardGajate, ConsueloMollinedo, FaustinoMuro, AntonioStrongyloidiasisAlkylphospholipidEdelfosineApoptosis33 p.-6 fig.-1 tab.Strongyloidiasis is widely distributed in the tropical and subtropical areas. Ivermectin is the drug of choice for the treatment. However, the concerns about relying treatment on a single drug make identification of new molecules a priority. Alkylphospholipid analogues, including edelfosine, are a group of synthetic compounds that have shown activity against some parasites. The objective was to assess the in vitro and in vivo activity of edelfosine, miltefosine, perifosine against Strongyloides venezuelensis. Moreover, apoptosis-like mechanism in larvae after treatment was studied. Edelfosine displayed the highest activity and the best selectivity index (LD50 = 49.6 ± 5.4 μM, SI = 1.1) compared to miltefosine or perifosine. Third stage larvae after culture with edelfosine were not able to develop an infection in mice. Treatment of mice with edelfosine showed reduction of 47% in parasitic females allocated in the gut. Moreover, DNA fragmentation was observed by TUNEL staining in larvae treated with edelfosine. These results suggest that edelfosine could be an effective drug against strongyloidiasis, probably through induction of apoptosis-like cell death.This work has been supported by Proyectos Integrados IBSAL (IBY15/00003; Salamanca, Spain; Spanish Ministerio de Economía y Competitividad (SAF2011-30518, SAF2014-59716-R, and RD12/0036/0065 from Red Temática de Investigación Cooperativa en Cáncer, Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional of the European Union), and the European Union’s Seventh Framework Programme FP7-2007-2013 (grant HEALTH-F2-2011-256986, PANACREAS).Peer reviewedElsevierMinisterio de Economía y Competitividad (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201620162016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/137211reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/256986http://dx.doi.org/10.1016/j.actatropica.2016.07.001Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1372112026-05-22T06:33:51Z
dc.title.none.fl_str_mv The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
spellingShingle The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
Legarda-Ceballos, Ana L.
Strongyloidiasis
Alkylphospholipid
Edelfosine
Apoptosis
title_short The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title_full The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title_fullStr The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title_full_unstemmed The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
title_sort The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death
dc.creator.none.fl_str_mv Legarda-Ceballos, Ana L.
Rojas-Caraballo, Jose
López-Abán, Julio
Ruano, A. L.
Yepes, Edward
Gajate, Consuelo
Mollinedo, Faustino
Muro, Antonio
author Legarda-Ceballos, Ana L.
author_facet Legarda-Ceballos, Ana L.
Rojas-Caraballo, Jose
López-Abán, Julio
Ruano, A. L.
Yepes, Edward
Gajate, Consuelo
Mollinedo, Faustino
Muro, Antonio
author_role author
author2 Rojas-Caraballo, Jose
López-Abán, Julio
Ruano, A. L.
Yepes, Edward
Gajate, Consuelo
Mollinedo, Faustino
Muro, Antonio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Strongyloidiasis
Alkylphospholipid
Edelfosine
Apoptosis
topic Strongyloidiasis
Alkylphospholipid
Edelfosine
Apoptosis
description 33 p.-6 fig.-1 tab.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/137211
url http://hdl.handle.net/10261/137211
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/256986
http://dx.doi.org/10.1016/j.actatropica.2016.07.001
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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