Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease

Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subs...

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Autores: Castells, Xavier|||0000-0002-2528-0382, Domingo, Laia|||0000-0003-4420-0891, Corominas Torres, Josep M.|||0000-0001-5049-7201, Torá-Rocamora, Isabel|||0000-0002-5946-4569, Quintana Ruiz, Maria Jesús|||0000-0002-1055-9786, Baré i Mañas, Marisa|||0000-0001-8085-2833, Vidal, Carmen|||0000-0003-2768-2710, Natal, Carmen|||0000-0003-0204-3947, Sánchez Movellán, Mar, Saladié, Francina|||0000-0002-1783-4066, Ferrer, Joana, Vernet-Tomas, Maria|||0000-0002-5575-2475, Servitja, Sonia|||0000-0001-6988-4519, Rodríguez Arana, Ana|||0000-0003-3115-0178, Roman, Marta, Espinàs, Josep Alfons, Sala, Maria|||0000-0002-9955-8746
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:300274
Acceso en línea:https://ddd.uab.cat/record/300274
https://dx.doi.org/urn:doi:10.1007/s10549-014-3208-z
Access Level:acceso abierto
Palabra clave:Benign breast disease
Breast cancer
Early detection
Family history
Risk factors
Screening
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network_name_str España
repository_id_str
spelling Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast diseasea study from a population-based screening programCastells, Xavier|||0000-0002-2528-0382Domingo, Laia|||0000-0003-4420-0891Corominas Torres, Josep M.|||0000-0001-5049-7201Torá-Rocamora, Isabel|||0000-0002-5946-4569Quintana Ruiz, Maria Jesús|||0000-0002-1055-9786Baré i Mañas, Marisa|||0000-0001-8085-2833Vidal, Carmen|||0000-0003-2768-2710Natal, Carmen|||0000-0003-0204-3947Sánchez Movellán, MarSaladié, Francina|||0000-0002-1783-4066Ferrer, JoanaVernet-Tomas, Maria|||0000-0002-5575-2475Servitja, Sonia|||0000-0001-6988-4519Rodríguez Arana, Ana|||0000-0003-3115-0178Roman, MartaEspinàs, Josep AlfonsSala, Maria|||0000-0002-9955-8746Benign breast diseaseBreast cancerEarly detectionFamily historyRisk factorsScreeningBenign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies.Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública 22015-01-0120152015-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/300274https://dx.doi.org/urn:doi:10.1007/s10549-014-3208-zreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01296open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3002742026-06-06T12:50:31Z
dc.title.none.fl_str_mv Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease
a study from a population-based screening program
title Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease
spellingShingle Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease
Castells, Xavier|||0000-0002-2528-0382
Benign breast disease
Breast cancer
Early detection
Family history
Risk factors
Screening
title_short Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease
title_full Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease
title_fullStr Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease
title_full_unstemmed Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease
title_sort Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease
dc.creator.none.fl_str_mv Castells, Xavier|||0000-0002-2528-0382
Domingo, Laia|||0000-0003-4420-0891
Corominas Torres, Josep M.|||0000-0001-5049-7201
Torá-Rocamora, Isabel|||0000-0002-5946-4569
Quintana Ruiz, Maria Jesús|||0000-0002-1055-9786
Baré i Mañas, Marisa|||0000-0001-8085-2833
Vidal, Carmen|||0000-0003-2768-2710
Natal, Carmen|||0000-0003-0204-3947
Sánchez Movellán, Mar
Saladié, Francina|||0000-0002-1783-4066
Ferrer, Joana
Vernet-Tomas, Maria|||0000-0002-5575-2475
Servitja, Sonia|||0000-0001-6988-4519
Rodríguez Arana, Ana|||0000-0003-3115-0178
Roman, Marta
Espinàs, Josep Alfons
Sala, Maria|||0000-0002-9955-8746
author Castells, Xavier|||0000-0002-2528-0382
author_facet Castells, Xavier|||0000-0002-2528-0382
Domingo, Laia|||0000-0003-4420-0891
Corominas Torres, Josep M.|||0000-0001-5049-7201
Torá-Rocamora, Isabel|||0000-0002-5946-4569
Quintana Ruiz, Maria Jesús|||0000-0002-1055-9786
Baré i Mañas, Marisa|||0000-0001-8085-2833
Vidal, Carmen|||0000-0003-2768-2710
Natal, Carmen|||0000-0003-0204-3947
Sánchez Movellán, Mar
Saladié, Francina|||0000-0002-1783-4066
Ferrer, Joana
Vernet-Tomas, Maria|||0000-0002-5575-2475
Servitja, Sonia|||0000-0001-6988-4519
Rodríguez Arana, Ana|||0000-0003-3115-0178
Roman, Marta
Espinàs, Josep Alfons
Sala, Maria|||0000-0002-9955-8746
author_role author
author2 Domingo, Laia|||0000-0003-4420-0891
Corominas Torres, Josep M.|||0000-0001-5049-7201
Torá-Rocamora, Isabel|||0000-0002-5946-4569
Quintana Ruiz, Maria Jesús|||0000-0002-1055-9786
Baré i Mañas, Marisa|||0000-0001-8085-2833
Vidal, Carmen|||0000-0003-2768-2710
Natal, Carmen|||0000-0003-0204-3947
Sánchez Movellán, Mar
Saladié, Francina|||0000-0002-1783-4066
Ferrer, Joana
Vernet-Tomas, Maria|||0000-0002-5575-2475
Servitja, Sonia|||0000-0001-6988-4519
Rodríguez Arana, Ana|||0000-0003-3115-0178
Roman, Marta
Espinàs, Josep Alfons
Sala, Maria|||0000-0002-9955-8746
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública
dc.subject.none.fl_str_mv Benign breast disease
Breast cancer
Early detection
Family history
Risk factors
Screening
topic Benign breast disease
Breast cancer
Early detection
Family history
Risk factors
Screening
description Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies.
publishDate 2015
dc.date.none.fl_str_mv 2
2015-01-01
2015
2015-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/300274
https://dx.doi.org/urn:doi:10.1007/s10549-014-3208-z
url https://ddd.uab.cat/record/300274
https://dx.doi.org/urn:doi:10.1007/s10549-014-3208-z
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01296
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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