Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.

Consistent findings indicate that Theory of Mind (ToM) is impaired in schizophrenia (SZ). To investigate whether such deficits are trait- or state-dependent, we investigated if ToM is modified by clinical liability markers (such as basic symptoms and psychotic-like experiences), focusing on the anal...

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Autores: Giralt López, Maria, Miret, Salvador, Campanera, Silvia, Moreira Martínez, Mónica, Sotero Moreno, Alejandro, Krebs, Marie Odile, Fañanás Saura, Lourdes, Fatjó-Vilas Mestre, Mar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/217457
Acceso en línea:https://hdl.handle.net/2445/217457
Access Level:acceso abierto
Palabra clave:Malalties mentals
Esquizofrènia
Mental illness
Schizophrenia
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spelling Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.Giralt López, MariaMiret, SalvadorCampanera, SilviaMoreira Martínez, MónicaSotero Moreno, AlejandroKrebs, Marie OdileFañanás Saura, LourdesFatjó-Vilas Mestre, MarMalalties mentalsEsquizofrèniaMental illnessSchizophreniaConsistent findings indicate that Theory of Mind (ToM) is impaired in schizophrenia (SZ). To investigate whether such deficits are trait- or state-dependent, we investigated if ToM is modified by clinical liability markers (such as basic symptoms and psychotic-like experiences), focusing on the analysis of unaffected siblings of individuals diagnosed with SZ. The study included a total of 65 participants: 38 patients diagnosed with a schizophrenia-spectrum disorder and 27 healthy siblings. ToM was assessed using the Hinting Task (HT), Basic symptoms with The Frankfurt Complaint Questionnaire (FCQ), Psychotic-like-experiences with the Community Assessment of Psychic Experiences (CAPE) and Family history with the Family Interview for Genetic Studies. First, a comparison of HT performance between patients and siblings (linear mixed model adjusted for age, sex and Intelligence Quotient (IQ)) showed that patients presented lower scores than siblings ( p = 0.022). These differences did not remain significant after adjusting for clinical vulnerability markers. Second, within siblings, linear regression analyses (adjusted for age, sex, IQ and family history) showed that higher FCQ Depressiveness and CAPE negative scores were related to poorer ToM performance ( p = 0.007 and p = 0.032, respectively). Our findings suggest that clinical liability markers are valuable for delineating variations in ToM capabilities within healthy individuals. Moreover, our results indicate that ToM deficits are not solely linked to SZ but also extend to its clinical vulnerability, suggesting that ToM could serve as an endophenotypic marker. This implies that ToM could help distinguish particularly susceptible individuals from a population at risk, such as those with a genetic predisposition (siblings).Frontiers Media2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/217457Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/doi: 10.3389/fpsyg.2024.1391646Frontiers in Psychology, 2024, vol. 15https://doi.org/doi: 10.3389/fpsyg.2024.1391646cc-by (c) Giralt López M. et al., 2024http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2174572026-05-27T06:46:51Z
dc.title.none.fl_str_mv Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.
title Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.
spellingShingle Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.
Giralt López, Maria
Malalties mentals
Esquizofrènia
Mental illness
Schizophrenia
title_short Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.
title_full Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.
title_fullStr Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.
title_full_unstemmed Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.
title_sort Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.
dc.creator.none.fl_str_mv Giralt López, Maria
Miret, Salvador
Campanera, Silvia
Moreira Martínez, Mónica
Sotero Moreno, Alejandro
Krebs, Marie Odile
Fañanás Saura, Lourdes
Fatjó-Vilas Mestre, Mar
author Giralt López, Maria
author_facet Giralt López, Maria
Miret, Salvador
Campanera, Silvia
Moreira Martínez, Mónica
Sotero Moreno, Alejandro
Krebs, Marie Odile
Fañanás Saura, Lourdes
Fatjó-Vilas Mestre, Mar
author_role author
author2 Miret, Salvador
Campanera, Silvia
Moreira Martínez, Mónica
Sotero Moreno, Alejandro
Krebs, Marie Odile
Fañanás Saura, Lourdes
Fatjó-Vilas Mestre, Mar
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties mentals
Esquizofrènia
Mental illness
Schizophrenia
topic Malalties mentals
Esquizofrènia
Mental illness
Schizophrenia
description Consistent findings indicate that Theory of Mind (ToM) is impaired in schizophrenia (SZ). To investigate whether such deficits are trait- or state-dependent, we investigated if ToM is modified by clinical liability markers (such as basic symptoms and psychotic-like experiences), focusing on the analysis of unaffected siblings of individuals diagnosed with SZ. The study included a total of 65 participants: 38 patients diagnosed with a schizophrenia-spectrum disorder and 27 healthy siblings. ToM was assessed using the Hinting Task (HT), Basic symptoms with The Frankfurt Complaint Questionnaire (FCQ), Psychotic-like-experiences with the Community Assessment of Psychic Experiences (CAPE) and Family history with the Family Interview for Genetic Studies. First, a comparison of HT performance between patients and siblings (linear mixed model adjusted for age, sex and Intelligence Quotient (IQ)) showed that patients presented lower scores than siblings ( p = 0.022). These differences did not remain significant after adjusting for clinical vulnerability markers. Second, within siblings, linear regression analyses (adjusted for age, sex, IQ and family history) showed that higher FCQ Depressiveness and CAPE negative scores were related to poorer ToM performance ( p = 0.007 and p = 0.032, respectively). Our findings suggest that clinical liability markers are valuable for delineating variations in ToM capabilities within healthy individuals. Moreover, our results indicate that ToM deficits are not solely linked to SZ but also extend to its clinical vulnerability, suggesting that ToM could serve as an endophenotypic marker. This implies that ToM could help distinguish particularly susceptible individuals from a population at risk, such as those with a genetic predisposition (siblings).
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/217457
url https://hdl.handle.net/2445/217457
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/doi: 10.3389/fpsyg.2024.1391646
Frontiers in Psychology, 2024, vol. 15
https://doi.org/doi: 10.3389/fpsyg.2024.1391646
dc.rights.none.fl_str_mv cc-by (c) Giralt López M. et al., 2024
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Giralt López M. et al., 2024
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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