Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area

The telencephalic subpallium is the source of various GABAergic interneuron cohorts that invade the pallium via tangential migration. Based on genoarchitectonic studies, the subpallium has been subdivided into four major domains: striatum, pallidum, diagonal area and preoptic area (Puelles et al. 20...

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Autores: Puelles, Luis, Morales Delgado, N., Merchán, P., Castro Robles, Beatriz, Martínez de la Torre, M., Díaz, C., Ferran, J. L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/59022
Acceso en línea:https://doi.org/10.1007/s00429-015-1086-8
http://hdl.handle.net/10459.1/59022
Access Level:acceso abierto
Palabra clave:Forebrain interneurons
Secondary prosencephalon
Subpallium
Pallidum
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spelling Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal areaPuelles, LuisMorales Delgado, N.Merchán, P.Castro Robles, BeatrizMartínez de la Torre, M.Díaz, C.Ferran, J. L.Forebrain interneuronsSecondary prosencephalonSubpalliumPallidumThe telencephalic subpallium is the source of various GABAergic interneuron cohorts that invade the pallium via tangential migration. Based on genoarchitectonic studies, the subpallium has been subdivided into four major domains: striatum, pallidum, diagonal area and preoptic area (Puelles et al. 2013; Allen Developing Mouse Brain Atlas), and a larger set of molecularly distinct progenitor areas (Flames et al. 2007). Fate mapping, genetic lineage-tracing studies, and other approaches have suggested that each subpallial subdivision produces specific sorts of inhibitory interneurons, distinguished by differential peptidic content, which are distributed tangentially to pallial and subpallial target territories (e.g., olfactory bulb, isocortex, hippocampus, pallial and subpallial amygdala, striatum, pallidum, septum). In this report, we map descriptively the early differentiation and apparent migratory dispersion of mouse subpallial somatostatin-expressing (Sst) cells from E10.5 onward, comparing their topography with the expression patterns of the genes Dlx5, Gbx2, Lhx7-8, Nkx2.1, Nkx5.1 (Hmx3), and Shh, which variously label parts of the subpallium. Whereas some experimental results suggest that Sst cells are pallidal, our data reveal that many, if not most, telencephalic Sst cells derive from de diagonal area (Dg). Sst-positive cells initially only present at the embryonic Dg selectively populate radially the medial part of the bed nucleus striae terminalis (from paraseptal to amygdaloid regions) and part of the central amygdala; they also invade tangentially the striatum, while eschewing the globus pallidum and the preoptic area, and integrate within most cortical and nuclear pallial areas between E10.5 and E16.5.This work was funded by the Spanish Ministry of Science and Innovation grant BFU2008-04156, and SENECA Foundation contract 0458/GERM/06-10891 to L.P.; and the Local Government of Castilla-La Mancha grant PII1I09-0065-8194 to C.D. Infrastructure support provided by the University of Murcia and Castilla-La Mancha is also acknowledged.Springer Berlin Heidelberg2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1007/s00429-015-1086-8http://hdl.handle.net/10459.1/59022reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMICINN/PN2008-2011/BFU2008-04156Reproducció del document publicat a https://doi.org/10.1007/s00429-015-1086-8Brain Structure and Function, 2016, vol. 221, núm. 6, p. 3027-3065cc-by (c) Puelles, Luis et al., 2015info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/oai:recercat.cat:10459.1/590222026-05-29T05:05:01Z
dc.title.none.fl_str_mv Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area
title Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area
spellingShingle Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area
Puelles, Luis
Forebrain interneurons
Secondary prosencephalon
Subpallium
Pallidum
title_short Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area
title_full Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area
title_fullStr Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area
title_full_unstemmed Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area
title_sort Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area
dc.creator.none.fl_str_mv Puelles, Luis
Morales Delgado, N.
Merchán, P.
Castro Robles, Beatriz
Martínez de la Torre, M.
Díaz, C.
Ferran, J. L.
author Puelles, Luis
author_facet Puelles, Luis
Morales Delgado, N.
Merchán, P.
Castro Robles, Beatriz
Martínez de la Torre, M.
Díaz, C.
Ferran, J. L.
author_role author
author2 Morales Delgado, N.
Merchán, P.
Castro Robles, Beatriz
Martínez de la Torre, M.
Díaz, C.
Ferran, J. L.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Forebrain interneurons
Secondary prosencephalon
Subpallium
Pallidum
topic Forebrain interneurons
Secondary prosencephalon
Subpallium
Pallidum
description The telencephalic subpallium is the source of various GABAergic interneuron cohorts that invade the pallium via tangential migration. Based on genoarchitectonic studies, the subpallium has been subdivided into four major domains: striatum, pallidum, diagonal area and preoptic area (Puelles et al. 2013; Allen Developing Mouse Brain Atlas), and a larger set of molecularly distinct progenitor areas (Flames et al. 2007). Fate mapping, genetic lineage-tracing studies, and other approaches have suggested that each subpallial subdivision produces specific sorts of inhibitory interneurons, distinguished by differential peptidic content, which are distributed tangentially to pallial and subpallial target territories (e.g., olfactory bulb, isocortex, hippocampus, pallial and subpallial amygdala, striatum, pallidum, septum). In this report, we map descriptively the early differentiation and apparent migratory dispersion of mouse subpallial somatostatin-expressing (Sst) cells from E10.5 onward, comparing their topography with the expression patterns of the genes Dlx5, Gbx2, Lhx7-8, Nkx2.1, Nkx5.1 (Hmx3), and Shh, which variously label parts of the subpallium. Whereas some experimental results suggest that Sst cells are pallidal, our data reveal that many, if not most, telencephalic Sst cells derive from de diagonal area (Dg). Sst-positive cells initially only present at the embryonic Dg selectively populate radially the medial part of the bed nucleus striae terminalis (from paraseptal to amygdaloid regions) and part of the central amygdala; they also invade tangentially the striatum, while eschewing the globus pallidum and the preoptic area, and integrate within most cortical and nuclear pallial areas between E10.5 and E16.5.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1007/s00429-015-1086-8
http://hdl.handle.net/10459.1/59022
url https://doi.org/10.1007/s00429-015-1086-8
http://hdl.handle.net/10459.1/59022
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv MICINN/PN2008-2011/BFU2008-04156
Reproducció del document publicat a https://doi.org/10.1007/s00429-015-1086-8
Brain Structure and Function, 2016, vol. 221, núm. 6, p. 3027-3065
dc.rights.none.fl_str_mv cc-by (c) Puelles, Luis et al., 2015
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
rights_invalid_str_mv cc-by (c) Puelles, Luis et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Berlin Heidelberg
publisher.none.fl_str_mv Springer Berlin Heidelberg
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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