Hepatitis G virus infection in chronic liver disease

Background-The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims-To evaluate the prevalence and meaning of HGV infection in a large series of patients wit...

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Autores: Guilera, M, Sáiz, JC, López-Labrador, FX, Olmedo, E, Ampurdanés, S, Forns, X, Bruix, J, Parés, A, Sánchez-Tapias, JM, de Anta, MTJ, Rodés, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1998
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p18081
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/18081
Access Level:acceso abierto
Palabra clave:chronic liver disease
hepatitis G virus
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spelling Hepatitis G virus infection in chronic liver diseaseGuilera, MSáiz, JCLópez-Labrador, FXOlmedo, EAmpurdanés, SForns, XBruix, JParés, ASánchez-Tapias, JMde Anta, MTJRodés, Jchronic liver diseasehepatitis G virusBackground-The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims-To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects-Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods-HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5' non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results-The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than noninfected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions-The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.BMJ PUBLISHING GROUP1998info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/18081GUTISSN: 00175749ISSNe: 14683288reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p180812026-06-11T12:45:17Z
dc.title.none.fl_str_mv Hepatitis G virus infection in chronic liver disease
title Hepatitis G virus infection in chronic liver disease
spellingShingle Hepatitis G virus infection in chronic liver disease
Guilera, M
chronic liver disease
hepatitis G virus
title_short Hepatitis G virus infection in chronic liver disease
title_full Hepatitis G virus infection in chronic liver disease
title_fullStr Hepatitis G virus infection in chronic liver disease
title_full_unstemmed Hepatitis G virus infection in chronic liver disease
title_sort Hepatitis G virus infection in chronic liver disease
dc.creator.none.fl_str_mv Guilera, M
Sáiz, JC
López-Labrador, FX
Olmedo, E
Ampurdanés, S
Forns, X
Bruix, J
Parés, A
Sánchez-Tapias, JM
de Anta, MTJ
Rodés, J
author Guilera, M
author_facet Guilera, M
Sáiz, JC
López-Labrador, FX
Olmedo, E
Ampurdanés, S
Forns, X
Bruix, J
Parés, A
Sánchez-Tapias, JM
de Anta, MTJ
Rodés, J
author_role author
author2 Sáiz, JC
López-Labrador, FX
Olmedo, E
Ampurdanés, S
Forns, X
Bruix, J
Parés, A
Sánchez-Tapias, JM
de Anta, MTJ
Rodés, J
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv chronic liver disease
hepatitis G virus
topic chronic liver disease
hepatitis G virus
description Background-The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims-To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects-Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods-HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5' non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results-The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than noninfected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions-The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.
publishDate 1998
dc.date.none.fl_str_mv 1998
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/18081
url https://fisabio.portalinvestigacion.com/publicaciones/18081
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ PUBLISHING GROUP
publisher.none.fl_str_mv BMJ PUBLISHING GROUP
dc.source.none.fl_str_mv GUT
ISSN: 00175749
ISSNe: 14683288
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
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