Antibody response in patients admitted to the hospital with suspected SARS-CoV-2 infection: results from a multicenter study across Spain

Aim: To evaluate the serological response against SARS-CoV-2 in a multicenter study representative of the Spanish COVID pandemic. Methods: IgG and IgM + IgA responses were measured on 1466 samples from 1236 Spanish COVID-19 patients admitted to the hospital, two commercial ELISA kits (Vircell SL, Sp...

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Authors: Fuentes, A. (Ana)|||/items/7b4fc3be-ed86-42b7-95a5-cb9c429885d4, Serrano-Conde, E. (Esther)|||/items/255289be-ab8a-4e32-b6b4-00258bd02634, Roldán, C. (Carolina)|||/items/4c01033b-10c9-47c7-9d19-40810d316825, Benito, R. (Rafael)|||/items/3431114e-609a-4861-893f-6816d503c4b8, Mejías, G. (Gregoria)|||/items/e0dc7726-98fb-40cd-994f-09974cb8f75d, Sampedro-Nuñez, M.A. (Miguel Antonio)|||/items/ebe0283a-614e-4b38-a4a2-b136e5f529c4, March-Roselló, G. (Gabriel)|||/items/16a51c03-866e-4f8a-a4d0-3cf1cfb089ab, Fernández-Natal, I. (Isabel)|||/items/62a250fc-0ac1-4851-ab79-7731cfb22c83, Esperalba, J. (Juliana)|||/items/c489bf4f-4fbb-40e6-b303-be813a9ef5bf, Rodríguez, M.J. (Mario José)|||/items/b5d00c10-8f4b-43c5-8b08-7ad79bf9c0d7, Martínez-de-Aguirre, P. (Paula)|||/items/75235790-3c62-4f8e-b0ba-871f9ed904fa, Salas, Carlos|||/items/c0c887f7-e8f8-47c0-9239-fc5517279a13, Roc, L. (Lourdes)|||/items/f7a13631-d18d-465f-a863-ced779e75a43, Soria, L.M. (Luis Miguel)|||/items/8de05540-eed0-4c8c-aab7-fbbe1c7b9e2a, Parra-Grande, M. (Mónica)|||/items/29afa8ac-a9a5-4388-bdc6-ccd548cc9cee, Montero, M.D. (María Dolores)|||/items/df35f394-f69b-47ee-84c4-6b3a08eebb21, Fernández-Roblas, R. (Ricardo)|||/items/40c2fd11-9a1d-4701-b8b2-6088392951d5, Franco-Álvarez-de-Luna, F. (Francisco)|||/items/946ca46a-d2e8-40e1-b9c3-c4879cdba82c, Lozano, C. (Carmen)|||/items/22d67f76-7067-41dd-a88d-1115ca2faaa0, Garcia, F. (Federico)|||/items/3f7e1dd8-2b2e-4977-98b2-20d9e6ed570c
Format: article
Publication Date:2021
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/114012
Online Access:https://hdl.handle.net/10171/114012
Access Level:Open access
Keyword:COVID-19
Diagnosis
IgA
IgG
IgM
SARS-COV-2
Description
Summary:Aim: To evaluate the serological response against SARS-CoV-2 in a multicenter study representative of the Spanish COVID pandemic. Methods: IgG and IgM + IgA responses were measured on 1466 samples from 1236 Spanish COVID-19 patients admitted to the hospital, two commercial ELISA kits (Vircell SL, Spain) based on the detection of antibodies against the viral spike protein and nucleoprotein, were used. Results: Approximately half of the patients presented antibodies (56.8% were IgM + IgA positive and 43.0% were IgG positive) as soon as 2 days after the first positive PCR result. Serological test positivity increased with time from the PCR test, and 10 days after the first PCR result, 91.5% and 88.0% of the patients presented IgM + IgA and IgG antibodies, respectively. Conclusion: The high values of sensitivity attained in the present study from a relatively early period of time after hospitalization support the use of the evaluated serological assays as supplementary diagnostic tests for the clinical management of COVID-19.

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