Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers
Objective In idiopathic Parkinson disease (IPD) sleep disorders are common and may antedate the onset of parkinsonism. Based on the clinical similarities between IPD and Parkinson disease associated with LRRK2 gene mutations (LRRK2-PD), we aimed to characterize sleep in parkinsonian and nonmanifesti...
| Autores: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/15663 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/15663 |
| Access Level: | acceso abierto |
| Palabra clave: | Electromyography Humans Demography Heterozygote Middle Aged Parkinson Disease Male Restless Legs Syndrome Mutation Sleep Wake Disorders Polysomnography REM Sleep Behavior Disorder Protein-Serine-Threonine Kinases Adult Female Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Protein Serine-Threonine Kinases Polisomnografía Proteínas Serina-Treonina Quinasas Trastornos del Sueño-Vigilia Trastorno de la Conducta del Sueño REM Femenino Mutación Masculino Electromiografía Demografía Humanos Persona de Mediana Edad Heterocigoto Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Enfermedad de Parkinson Síndrome de las Piernas Inquietas Adulto |
| id |
ES_7cdfdedc2cd761a1fb9b9b9eef408001 |
|---|---|
| oai_identifier_str |
oai:docusalut.com:20.500.13003/15663 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation CarriersPont-Sunyer, ClaustreIranzo, AlexGaig, CarlesFernandez-Arcos, AnaVilas, DoloresValldeoriola, FrancescCompta, YaroslauFernandez-Santiago, RubenFernandez, ManuelBayes, AngelsCalopa, MatildeCasquero Subías, Pilarde Fabregues-Boixar, OriolJauma, SergePuente, VictorSalamero, ManelMarti, Maria JoseSantamaria Semis, JoanTolosa, EduardElectromyographyHumansDemographyHeterozygoteMiddle AgedParkinson DiseaseMaleRestless Legs SyndromeMutationSleep Wake DisordersPolysomnographyREM Sleep Behavior DisorderProtein-Serine-Threonine KinasesAdultFemaleLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Protein Serine-Threonine KinasesPolisomnografíaProteínas Serina-Treonina QuinasasTrastornos del Sueño-VigiliaTrastorno de la Conducta del Sueño REMFemeninoMutaciónMasculinoElectromiografíaDemografíaHumanosPersona de Mediana EdadHeterocigotoProteína 2 Quinasa Serina-Treonina Rica en Repeticiones de LeucinaEnfermedad de ParkinsonSíndrome de las Piernas InquietasAdultoObjective In idiopathic Parkinson disease (IPD) sleep disorders are common and may antedate the onset of parkinsonism. Based on the clinical similarities between IPD and Parkinson disease associated with LRRK2 gene mutations (LRRK2-PD), we aimed to characterize sleep in parkinsonian and nonmanifesting LRRK2 mutation carriers (NMC). Methods A comprehensive interview conducted by sleep specialists, validated sleep scales and questionnaires, and video-polysomnography followed by multiple sleep latency test (MSLT) assessed sleep in 18 LRRK2-PD (17 carrying G2019S and one R1441G mutations), 17 NMC (11 G2019S, three R1441G, three R1441C), 14 non-manifesting non-carriers (NMNC) and 19 unrelated IPD. Results Sleep complaints were frequent in LRRK2-PD patients; 78% reported poor sleep quality, 33% sleep onset insomnia, 56% sleep fragmentation and 39% early awakening. Sleep onset insomnia correlated with depressive symptoms and poor sleep quality. In LRRK2-PD, excessive daytime sleepiness (EDS) was a complaint in 33% patients and short sleep latencies on the MSLT, which are indicative of objective EDS, were found in 71%. Sleep attacks occurred in three LRRK2-PD patients and a narcoleptic phenotype was not observed. REM sleep behavior disorder (RBD) was diagnosed in three LRRK2-PD. EDS and RBD were always reported to start after the onset of parkinsonism in LRRK2-PD. In NMC, EDS was rarely reported and RBD was absent. When compared to IPD, sleep onset insomnia was more significantly frequent, EDS was similar, and RBD was less significantly frequent and less severe in LRRK2-PD. In NMC, RBD was not detected and sleep complaints were much less frequent than in LRRK2-PD. No differences were observed in sleep between NMC and NMNC. Conclusions Sleep complaints are frequent in LRRK2-PDand show a pattern that when compared to IPD is characterized by more frequent sleep onset insomnia, similar EDS and less prominent RBD. Unlike in IPD, RBD and EDS seem to be not markers of the prodromal stage of LRRK2-PD.Public Library Science20152015-07-1520152015-07-15research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/15663reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/156632026-06-22T12:44:07Z |
| dc.title.none.fl_str_mv |
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers |
| title |
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers |
| spellingShingle |
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers Pont-Sunyer, Claustre Electromyography Humans Demography Heterozygote Middle Aged Parkinson Disease Male Restless Legs Syndrome Mutation Sleep Wake Disorders Polysomnography REM Sleep Behavior Disorder Protein-Serine-Threonine Kinases Adult Female Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Protein Serine-Threonine Kinases Polisomnografía Proteínas Serina-Treonina Quinasas Trastornos del Sueño-Vigilia Trastorno de la Conducta del Sueño REM Femenino Mutación Masculino Electromiografía Demografía Humanos Persona de Mediana Edad Heterocigoto Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Enfermedad de Parkinson Síndrome de las Piernas Inquietas Adulto |
| title_short |
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers |
| title_full |
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers |
| title_fullStr |
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers |
| title_full_unstemmed |
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers |
| title_sort |
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers |
| dc.creator.none.fl_str_mv |
Pont-Sunyer, Claustre Iranzo, Alex Gaig, Carles Fernandez-Arcos, Ana Vilas, Dolores Valldeoriola, Francesc Compta, Yaroslau Fernandez-Santiago, Ruben Fernandez, Manuel Bayes, Angels Calopa, Matilde Casquero Subías, Pilar de Fabregues-Boixar, Oriol Jauma, Serge Puente, Victor Salamero, Manel Marti, Maria Jose Santamaria Semis, Joan Tolosa, Eduard |
| author |
Pont-Sunyer, Claustre |
| author_facet |
Pont-Sunyer, Claustre Iranzo, Alex Gaig, Carles Fernandez-Arcos, Ana Vilas, Dolores Valldeoriola, Francesc Compta, Yaroslau Fernandez-Santiago, Ruben Fernandez, Manuel Bayes, Angels Calopa, Matilde Casquero Subías, Pilar de Fabregues-Boixar, Oriol Jauma, Serge Puente, Victor Salamero, Manel Marti, Maria Jose Santamaria Semis, Joan Tolosa, Eduard |
| author_role |
author |
| author2 |
Iranzo, Alex Gaig, Carles Fernandez-Arcos, Ana Vilas, Dolores Valldeoriola, Francesc Compta, Yaroslau Fernandez-Santiago, Ruben Fernandez, Manuel Bayes, Angels Calopa, Matilde Casquero Subías, Pilar de Fabregues-Boixar, Oriol Jauma, Serge Puente, Victor Salamero, Manel Marti, Maria Jose Santamaria Semis, Joan Tolosa, Eduard |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
|
| dc.subject.none.fl_str_mv |
Electromyography Humans Demography Heterozygote Middle Aged Parkinson Disease Male Restless Legs Syndrome Mutation Sleep Wake Disorders Polysomnography REM Sleep Behavior Disorder Protein-Serine-Threonine Kinases Adult Female Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Protein Serine-Threonine Kinases Polisomnografía Proteínas Serina-Treonina Quinasas Trastornos del Sueño-Vigilia Trastorno de la Conducta del Sueño REM Femenino Mutación Masculino Electromiografía Demografía Humanos Persona de Mediana Edad Heterocigoto Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Enfermedad de Parkinson Síndrome de las Piernas Inquietas Adulto |
| topic |
Electromyography Humans Demography Heterozygote Middle Aged Parkinson Disease Male Restless Legs Syndrome Mutation Sleep Wake Disorders Polysomnography REM Sleep Behavior Disorder Protein-Serine-Threonine Kinases Adult Female Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Protein Serine-Threonine Kinases Polisomnografía Proteínas Serina-Treonina Quinasas Trastornos del Sueño-Vigilia Trastorno de la Conducta del Sueño REM Femenino Mutación Masculino Electromiografía Demografía Humanos Persona de Mediana Edad Heterocigoto Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Enfermedad de Parkinson Síndrome de las Piernas Inquietas Adulto |
| description |
Objective In idiopathic Parkinson disease (IPD) sleep disorders are common and may antedate the onset of parkinsonism. Based on the clinical similarities between IPD and Parkinson disease associated with LRRK2 gene mutations (LRRK2-PD), we aimed to characterize sleep in parkinsonian and nonmanifesting LRRK2 mutation carriers (NMC). Methods A comprehensive interview conducted by sleep specialists, validated sleep scales and questionnaires, and video-polysomnography followed by multiple sleep latency test (MSLT) assessed sleep in 18 LRRK2-PD (17 carrying G2019S and one R1441G mutations), 17 NMC (11 G2019S, three R1441G, three R1441C), 14 non-manifesting non-carriers (NMNC) and 19 unrelated IPD. Results Sleep complaints were frequent in LRRK2-PD patients; 78% reported poor sleep quality, 33% sleep onset insomnia, 56% sleep fragmentation and 39% early awakening. Sleep onset insomnia correlated with depressive symptoms and poor sleep quality. In LRRK2-PD, excessive daytime sleepiness (EDS) was a complaint in 33% patients and short sleep latencies on the MSLT, which are indicative of objective EDS, were found in 71%. Sleep attacks occurred in three LRRK2-PD patients and a narcoleptic phenotype was not observed. REM sleep behavior disorder (RBD) was diagnosed in three LRRK2-PD. EDS and RBD were always reported to start after the onset of parkinsonism in LRRK2-PD. In NMC, EDS was rarely reported and RBD was absent. When compared to IPD, sleep onset insomnia was more significantly frequent, EDS was similar, and RBD was less significantly frequent and less severe in LRRK2-PD. In NMC, RBD was not detected and sleep complaints were much less frequent than in LRRK2-PD. No differences were observed in sleep between NMC and NMNC. Conclusions Sleep complaints are frequent in LRRK2-PDand show a pattern that when compared to IPD is characterized by more frequent sleep onset insomnia, similar EDS and less prominent RBD. Unlike in IPD, RBD and EDS seem to be not markers of the prodromal stage of LRRK2-PD. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2015-07-15 2015 2015-07-15 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.13003/15663 |
| url |
https://hdl.handle.net/20.500.13003/15663 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Public Library Science |
| publisher.none.fl_str_mv |
Public Library Science |
| dc.source.none.fl_str_mv |
reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears |
| instname_str |
Conselleria de Salut i Consum del Govern de les Illes Balears |
| reponame_str |
Docusalut |
| collection |
Docusalut |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869411621880725504 |
| score |
15.811543 |