Seven-month kinetics of SARS-CoV-2 antibodies and role of pre-existing antibodies to human coronaviruses

Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential to understand protective immunity to COVID-19 and devise effective surveil...

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Detalles Bibliográficos
Autores: Ortega, Natalia, Ribes, Marta, Vidal, Marta, Rubio Bodí, Rocío, Aguilar, Ruth, Williams, Sarah, Barrios, Diana, Alonso, Selena, Hernández-Luis, Pablo, Mitchell, Robert, Jairoce, Chenjerai, Cruz Vazquez, Angeline Marie, JIMENEZ, ALFONS, Santano García, Rebeca, Méndez, Susana, Lamoglia Puig, Montserrat, Rosell, Neus, Llupià, Anna, Puyol, Laura, Chi, Jordi, Rodrigo Melero, Natalia, Parras, Daniel, Serra, Pau, Pradenas, Edwards, Trinité, Benjamin, Blanco, Julià, Mayor Aparicio, Alfredo Gabriel, Barroso, Sonia, Varela, Pilar, Vilella, Anna, Trilla, Antoni, Santamaria, Pere, Carolis, Carlo, Tortajada, Marta, Izquierdo, Luis, Angulo, Ana, Engel, Pablo, Garcia-Basteiro, Alberto L., Moncunill, Gemma, Dobaño Lazaro, Carlota
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12367/2574
Acceso en línea:https://hdl.handle.net/20.500.12367/2574
Access Level:acceso abierto
Palabra clave:Infection
SARS-CoV-2
Viral infection
Descripción
Sumario:Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential to understand protective immunity to COVID-19 and devise effective surveillance strategies. IgM, IgA and IgG levels against six SARS-CoV-2 antigens and the nucleocapsid antigen of the four HCoV (229E, NL63, OC43 and HKU1) were quantified by Luminex, and antibody neutralization capacity was assessed by flow cytometry, in a cohort of health care workers followed up to 7 months (N = 578). Seroprevalence increases over time from 13.5% (month 0) and 15.6% (month 1) to 16.4% (month 6). [...]

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