Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis

Bronchiectasis; Dry powder inhaled; Inhaled antibiotics

Detalles Bibliográficos
Autores: Ramírez-Estrada, Sergio, Forero, Carlos G., Gallego, Miguel, Cardinal-Fernandez, P, Ehrmann, Stephan, Rello Condomines, Jordi, Soriano, Joan B, Tejada Magraner, Sofia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/7886
Acceso en línea:https://hdl.handle.net/11351/7886
Access Level:acceso abierto
Palabra clave:Bronquièctasi - Tractament
Avaluació de resultats (Assistència sanitària)
Teràpia respiratòria
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
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network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis
title Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis
spellingShingle Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis
Ramírez-Estrada, Sergio
Bronquièctasi - Tractament
Avaluació de resultats (Assistència sanitària)
Teràpia respiratòria
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
title_short Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis
title_full Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis
title_fullStr Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis
title_full_unstemmed Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis
title_sort Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis
dc.creator.none.fl_str_mv Ramírez-Estrada, Sergio
Forero, Carlos G.
Gallego, Miguel
Cardinal-Fernandez, P
Ehrmann, Stephan
Rello Condomines, Jordi
Soriano, Joan B
Tejada Magraner, Sofia
author Ramírez-Estrada, Sergio
author_facet Ramírez-Estrada, Sergio
Forero, Carlos G.
Gallego, Miguel
Cardinal-Fernandez, P
Ehrmann, Stephan
Rello Condomines, Jordi
Soriano, Joan B
Tejada Magraner, Sofia
author_role author
author2 Forero, Carlos G.
Gallego, Miguel
Cardinal-Fernandez, P
Ehrmann, Stephan
Rello Condomines, Jordi
Soriano, Joan B
Tejada Magraner, Sofia
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Tejada S] Grup de Recerca Clínica/Innovació en Pneumònia i Sèpsia (CRIPS), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. [Ramírez-Estrada S] Intensive Care Department, Clínica Corachán, Barcelona, Spain. [Forero CG] School of Medicine, Universitat Internacional de Catalunya, Barcelona, Spain. [Gallego M] Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. Respiratory Department, Parc Taulí University Hospital, Barcelona, Spain. [Soriano JB] Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. Hospital Universitario La Princesa, Universidad Autónoma de Madrid, Madrid, Spain. [Cardinal-Fernández PA] Intensive Care Unit, HM Group, Madrid, Spain. [Ehrmann S] CHRU Tours, Médecine Intensive Réanimation, CIC INSERM 1415, CRICS-TriggerSEP F-CRIN Research Network, Tours, France. Centre d’étude des Pathologies Respiratoires, INSERM U1100, Université de Tours, Tours, France. [Rello J] Grup de Recerca Clínica/Innovació en Pneumònia i Sèpsia (CRIPS), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Clinical Research in the ICU, CHU Nimes, Universite de Nimes-Montpellier, Nimes, France. Medicine Department, Universitat Internacional de Catalunya (UIC), Sant Cugat, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Bronquièctasi - Tractament
Avaluació de resultats (Assistència sanitària)
Teràpia respiratòria
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
topic Bronquièctasi - Tractament
Avaluació de resultats (Assistència sanitària)
Teràpia respiratòria
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
description Bronchiectasis; Dry powder inhaled; Inhaled antibiotics
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7886
url https://hdl.handle.net/11351/7886
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Antibiotics;11(2)
https://doi.org/10.3390/antibiotics11020275
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411619613704192
spelling Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-AnalysisRamírez-Estrada, SergioForero, Carlos G.Gallego, MiguelCardinal-Fernandez, PEhrmann, StephanRello Condomines, JordiSoriano, Joan BTejada Magraner, SofiaBronquièctasi - TractamentAvaluació de resultats (Assistència sanitària)Teràpia respiratòriaDISEASES::Respiratory Tract Diseases::Bronchial Diseases::BronchiectasisOther subheadings::Other subheadings::Other subheadings::/drug therapyENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasiaOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaBronchiectasis; Dry powder inhaled; Inhaled antibioticsBronquiectasias; Polvo seco inhalado; Antibióticos inhaladosBronquiectasies; Pols seca inhalada; Antibiòtics inhalatsIt remains unknown whether the type of aerosol generating device is affecting efficacy and safety among non-cystic fibrosis bronchiectasis (NCFB) adults. The proposal of this network meta-analysis (NMA) is to evaluate effectiveness and safety of inhaled antibiotics administered via dry powder inhaler (DPI) and via nebulizers (SVN) among adult patients with NCFB. Inclusion criteria were randomized-controlled trials, adults (≥18 years) with NCFB, and inhaled antibiotics administered via DPI as intervention. Search strategy was performed in PubMed, Web of Science, and Cochrane Library from 2000 to 2019. Sixteen trials (2870 patients) were included. Three trials (all ciprofloxacin) used DPIs and thirteen used SVN (three ciprofloxacin). Both DPI and SVN devices achieved similar safety outcomes (adverse events, antibiotic discontinuation, severe adverse events, and bronchospasm). Administration of ciprofloxacin via DPI significantly improved time to first exacerbation (87 days, 95% CI 34.3–139.7) and quality of life (MD −7.52; 95% CI −13.06 to −1.98) when compared with via SVN. No other significant differences were documented in clinical efficacy (at least one exacerbation, FEV1% predicted) and microbiologic response (bacterial eradication, emergence of new potential pathogens, and emergence of antimicrobial resistance) when comparing devices. Our NMA documented that time to first exacerbation and quality of life, were more favorable for DPIs. Decisions on the choice of devices should incorporate these findings plus other criteria, such as simplicity, costs or maintenance requirements.This work was funded by CIBERES, Instituto de Salud Carlos III, Madrid, Spain (Fondos FEDER) (CB06-06-036).MDPIInstitut Català de la Salut[Tejada S] Grup de Recerca Clínica/Innovació en Pneumònia i Sèpsia (CRIPS), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. [Ramírez-Estrada S] Intensive Care Department, Clínica Corachán, Barcelona, Spain. [Forero CG] School of Medicine, Universitat Internacional de Catalunya, Barcelona, Spain. [Gallego M] Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. Respiratory Department, Parc Taulí University Hospital, Barcelona, Spain. [Soriano JB] Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. Hospital Universitario La Princesa, Universidad Autónoma de Madrid, Madrid, Spain. [Cardinal-Fernández PA] Intensive Care Unit, HM Group, Madrid, Spain. [Ehrmann S] CHRU Tours, Médecine Intensive Réanimation, CIC INSERM 1415, CRICS-TriggerSEP F-CRIN Research Network, Tours, France. Centre d’étude des Pathologies Respiratoires, INSERM U1100, Université de Tours, Tours, France. [Rello J] Grup de Recerca Clínica/Innovació en Pneumònia i Sèpsia (CRIPS), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Clinical Research in the ICU, CHU Nimes, Universite de Nimes-Montpellier, Nimes, France. Medicine Department, Universitat Internacional de Catalunya (UIC), Sant Cugat, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7886Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésAntibiotics;11(2)https://doi.org/10.3390/antibiotics11020275Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/78862026-06-12T09:38:37Z
score 15.81155

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