Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model

Age-related hearing loss (ARHL) impairs the quality of life in elderly persons. ARHL is associated with comorbidities, such as depression, falls, or frailty. Frailty syndrome is related to poor health outcomes in old age. ARHL is a potentially modifiable risk factor for frailty. Oxidative stress has...

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Autores: Heredia Molina, Rosalía Fátima, Riestra Ayora, Juan Ignacio, Yanes Díaz, Joaquín, Thuissard Vasallo, Israel John, Andreu Vázquez, Cristina, Sanz Fernández, Ricardo, Sánchez Rodríguez, Carolina
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/12379
Acceso en línea:http://hdl.handle.net/11268/12379
Access Level:acceso abierto
Palabra clave:Antioxidantes
Polifenoles
Cacao
Nutrición
Efectos fisiológicos
Química orgánica
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spelling Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo ModelHeredia Molina, Rosalía FátimaRiestra Ayora, Juan IgnacioYanes Díaz, JoaquínThuissard Vasallo, Israel JohnAndreu Vázquez, CristinaSanz Fernández, RicardoSánchez Rodríguez, CarolinaAntioxidantesPolifenolesCacaoNutriciónEfectos fisiológicosQuímica orgánicaAge-related hearing loss (ARHL) impairs the quality of life in elderly persons. ARHL is associated with comorbidities, such as depression, falls, or frailty. Frailty syndrome is related to poor health outcomes in old age. ARHL is a potentially modifiable risk factor for frailty. Oxidative stress has been proposed as a key factor underlying the onset and/or development of ARHL and frailty. Cocoa has high levels of polyphenols and provides many health benefits due to its antioxidant properties. Male and female C57Bl/6J mice were randomly assigned to two study groups: animals receiving a cocoa-supplemented diet and the other receiving a standard diet. Then, at the ages of 6, 14, and 22 months, hearing and frailty were measured in all mice. Auditory steady-state responses (ASSR) threshold shifts were measured to different frequencies. The frailty score was based on the “Valencia Score” adapted to the experimental animals. The total antioxidant capacity and total polyphenols in urine samples were also measured. Significant improvements in hearing ability are observed in the cocoa groups at 6, 14, and 22 months compared to the no cocoa group. The cocoa diet significantly retards the development of frailty in mice. Cocoa increases the concentration of polyphenols excreted in the urine, which increases the total antioxidant capacity. In conclusion, cocoa, due to its antioxidant properties, leads to significant protection against ARHL and frailty.20232023-11-2120232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/12379reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/123792026-06-11T12:41:27Z
dc.title.none.fl_str_mv Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
spellingShingle Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
Heredia Molina, Rosalía Fátima
Antioxidantes
Polifenoles
Cacao
Nutrición
Efectos fisiológicos
Química orgánica
title_short Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title_full Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title_fullStr Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title_full_unstemmed Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
title_sort Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model
dc.creator.none.fl_str_mv Heredia Molina, Rosalía Fátima
Riestra Ayora, Juan Ignacio
Yanes Díaz, Joaquín
Thuissard Vasallo, Israel John
Andreu Vázquez, Cristina
Sanz Fernández, Ricardo
Sánchez Rodríguez, Carolina
author Heredia Molina, Rosalía Fátima
author_facet Heredia Molina, Rosalía Fátima
Riestra Ayora, Juan Ignacio
Yanes Díaz, Joaquín
Thuissard Vasallo, Israel John
Andreu Vázquez, Cristina
Sanz Fernández, Ricardo
Sánchez Rodríguez, Carolina
author_role author
author2 Riestra Ayora, Juan Ignacio
Yanes Díaz, Joaquín
Thuissard Vasallo, Israel John
Andreu Vázquez, Cristina
Sanz Fernández, Ricardo
Sánchez Rodríguez, Carolina
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Antioxidantes
Polifenoles
Cacao
Nutrición
Efectos fisiológicos
Química orgánica
topic Antioxidantes
Polifenoles
Cacao
Nutrición
Efectos fisiológicos
Química orgánica
description Age-related hearing loss (ARHL) impairs the quality of life in elderly persons. ARHL is associated with comorbidities, such as depression, falls, or frailty. Frailty syndrome is related to poor health outcomes in old age. ARHL is a potentially modifiable risk factor for frailty. Oxidative stress has been proposed as a key factor underlying the onset and/or development of ARHL and frailty. Cocoa has high levels of polyphenols and provides many health benefits due to its antioxidant properties. Male and female C57Bl/6J mice were randomly assigned to two study groups: animals receiving a cocoa-supplemented diet and the other receiving a standard diet. Then, at the ages of 6, 14, and 22 months, hearing and frailty were measured in all mice. Auditory steady-state responses (ASSR) threshold shifts were measured to different frequencies. The frailty score was based on the “Valencia Score” adapted to the experimental animals. The total antioxidant capacity and total polyphenols in urine samples were also measured. Significant improvements in hearing ability are observed in the cocoa groups at 6, 14, and 22 months compared to the no cocoa group. The cocoa diet significantly retards the development of frailty in mice. Cocoa increases the concentration of polyphenols excreted in the urine, which increases the total antioxidant capacity. In conclusion, cocoa, due to its antioxidant properties, leads to significant protection against ARHL and frailty.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-11-21
2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/12379
url http://hdl.handle.net/11268/12379
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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