Role of innate and adaptive cytokines in the survival of COVID-19 patients
20 p.
| Autores: | , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:ebuahbibliot::110b93a64ed6adad16fdca4a5d153c46 |
| Acceso en línea: | http://hdl.handle.net/10017/69065 https://dx.doi.org/10.3390/ijms231810344 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 Biomarkers Chemokines Growth factors Innate and adaptive cytokines Prognosis Medicina Medicine |
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Role of innate and adaptive cytokines in the survival of COVID-19 patientsMonserrat Sanz, Jorge|||0000-0003-1775-4645Gómez Lahoz, Ana María|||0000-0003-3981-5138Ortega Núñez, Miguel Ángel|||0000-0003-2588-1708Sanz, JoséMuñoz Calvo, Benjamín FranciscoArévalo Serrano, Juan|||0000-0003-2563-7860González-Moro Rodríguez, José Miguel|||0000-0002-8446-3373Gasalla Herráiz, José ManuelGasulla Montardit, ÓscarArranz Caso, José AlbertoFortuny Profitós, JordiMazaira Font, Ferrán AntonioTeixidó Román, MiguelMartínez Alonso, CarlosBalomenos, DimitriAsúnsolo Del Barco, Ángel|||0000-0001-7898-4685Álvarez De Mon Soto, Melchor|||0000-0003-1309-7510COVID-19BiomarkersChemokinesGrowth factorsInnate and adaptive cytokinesPrognosisMedicinaMedicine20 p.The Covid-Hupa GroupAbstract: SARS-CoV-2 is a new coronavirus characterized by a high infection and transmission capacity. A significant number of patients develop inadequate immune responses that produce massive releases of cytokines that compromise their survival. Soluble factors are clinically and pathologically relevant in COVID-19 survival but remain only partially characterized. The objective of this work was to simultaneously study 62 circulating soluble factors, including innate and adaptive cytokines and their soluble receptors, chemokines and growth and wound-healing/repair factors, in severe COVID-19 patients who survived compared to those with fatal outcomes. Serum samples were obtained from 286 COVID-19 patients and 40 healthy controls. The 62 circulating soluble factors were quantified using a Luminex Milliplex assay. Results. The patients who survived had decreased levels of the following 30 soluble factors of the 62 studied compared to those with fatal outcomes, therefore, these decreases were observed for cytokines and receptors predominantly produced by the innate immune system?IL-1?, IL-1?, IL-18, IL-15, IL-12p40, IL-6, IL-27, IL-1Ra, IL-1RI, IL-1RII, TNF?, TGF?, IL-10, sRAGE, sTNF-RI and sTNF-RII?for the chemokines IL-8, IP-10, MCP-1, MCP-3, MIG and fractalkine; for the growth factors M-CSF and the soluble receptor sIL2Ra; for the cytokines involved in the adaptive immune system IFN , IL-17 and sIL-4R; and for the wound-repair factor FGF2. On the other hand, the patients who survived had elevated levels of the soluble factors TNF?, sCD40L, MDC, RANTES, G-CSF, GM-CSF, EGF, PDGFAA and PDGFABBB compared to those who died. Conclusions. Increases in the circulating levels of the sCD40L cytokine; MDC and RANTES chemokines; the G-CSF and GM-CSF growth factors, EGF, PDGFAA and PDGFABBB; and tissue-repair factors are strongly associated with survival. By contrast, large increases in IL-15, IL-6, IL-18, IL-27 and IL-10; the sIL-1RI, sIL1RII and sTNF-RII receptors; the MCP3, IL-8, MIG and IP-10 chemokines; the M-CSF and sIL-2Ra growth factors; and the wound-healing factor FGF2 favor fatal outcomes of the disease.Comunidad de MadridUniversidad de AlcaláProA CapitalHalekulani S.L.MJRFundación Startlite20222022-09-07journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/69065https://dx.doi.org/10.3390/ijms23181034436142255reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengUAH Not available 2019%2F00003%2F016%2F001%2F026UAH Not available 2021-2020%2F00003%2F016%2F001%2F027Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available B2020%2MITICAD-CMopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:ebuahbibliot::110b93a64ed6adad16fdca4a5d153c462026-06-18T11:13:07Z |
| dc.title.none.fl_str_mv |
Role of innate and adaptive cytokines in the survival of COVID-19 patients |
| title |
Role of innate and adaptive cytokines in the survival of COVID-19 patients |
| spellingShingle |
Role of innate and adaptive cytokines in the survival of COVID-19 patients Monserrat Sanz, Jorge|||0000-0003-1775-4645 COVID-19 Biomarkers Chemokines Growth factors Innate and adaptive cytokines Prognosis Medicina Medicine |
| title_short |
Role of innate and adaptive cytokines in the survival of COVID-19 patients |
| title_full |
Role of innate and adaptive cytokines in the survival of COVID-19 patients |
| title_fullStr |
Role of innate and adaptive cytokines in the survival of COVID-19 patients |
| title_full_unstemmed |
Role of innate and adaptive cytokines in the survival of COVID-19 patients |
| title_sort |
Role of innate and adaptive cytokines in the survival of COVID-19 patients |
| dc.creator.none.fl_str_mv |
Monserrat Sanz, Jorge|||0000-0003-1775-4645 Gómez Lahoz, Ana María|||0000-0003-3981-5138 Ortega Núñez, Miguel Ángel|||0000-0003-2588-1708 Sanz, José Muñoz Calvo, Benjamín Francisco Arévalo Serrano, Juan|||0000-0003-2563-7860 González-Moro Rodríguez, José Miguel|||0000-0002-8446-3373 Gasalla Herráiz, José Manuel Gasulla Montardit, Óscar Arranz Caso, José Alberto Fortuny Profitós, Jordi Mazaira Font, Ferrán Antonio Teixidó Román, Miguel Martínez Alonso, Carlos Balomenos, Dimitri Asúnsolo Del Barco, Ángel|||0000-0001-7898-4685 Álvarez De Mon Soto, Melchor|||0000-0003-1309-7510 |
| author |
Monserrat Sanz, Jorge|||0000-0003-1775-4645 |
| author_facet |
Monserrat Sanz, Jorge|||0000-0003-1775-4645 Gómez Lahoz, Ana María|||0000-0003-3981-5138 Ortega Núñez, Miguel Ángel|||0000-0003-2588-1708 Sanz, José Muñoz Calvo, Benjamín Francisco Arévalo Serrano, Juan|||0000-0003-2563-7860 González-Moro Rodríguez, José Miguel|||0000-0002-8446-3373 Gasalla Herráiz, José Manuel Gasulla Montardit, Óscar Arranz Caso, José Alberto Fortuny Profitós, Jordi Mazaira Font, Ferrán Antonio Teixidó Román, Miguel Martínez Alonso, Carlos Balomenos, Dimitri Asúnsolo Del Barco, Ángel|||0000-0001-7898-4685 Álvarez De Mon Soto, Melchor|||0000-0003-1309-7510 |
| author_role |
author |
| author2 |
Gómez Lahoz, Ana María|||0000-0003-3981-5138 Ortega Núñez, Miguel Ángel|||0000-0003-2588-1708 Sanz, José Muñoz Calvo, Benjamín Francisco Arévalo Serrano, Juan|||0000-0003-2563-7860 González-Moro Rodríguez, José Miguel|||0000-0002-8446-3373 Gasalla Herráiz, José Manuel Gasulla Montardit, Óscar Arranz Caso, José Alberto Fortuny Profitós, Jordi Mazaira Font, Ferrán Antonio Teixidó Román, Miguel Martínez Alonso, Carlos Balomenos, Dimitri Asúnsolo Del Barco, Ángel|||0000-0001-7898-4685 Álvarez De Mon Soto, Melchor|||0000-0003-1309-7510 |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
COVID-19 Biomarkers Chemokines Growth factors Innate and adaptive cytokines Prognosis Medicina Medicine |
| topic |
COVID-19 Biomarkers Chemokines Growth factors Innate and adaptive cytokines Prognosis Medicina Medicine |
| description |
20 p. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-09-07 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10017/69065 https://dx.doi.org/10.3390/ijms231810344 36142255 |
| url |
http://hdl.handle.net/10017/69065 https://dx.doi.org/10.3390/ijms231810344 |
| identifier_str_mv |
36142255 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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UAH Not available 2019%2F00003%2F016%2F001%2F026 UAH Not available 2021-2020%2F00003%2F016%2F001%2F027 Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available B2020%2MITICAD-CM |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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