Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS Analysis

Intoxication due to the consumption of poppy seed teas has been reported due to their contamination with opium alkaloids (OAs). In this work, an efficient methodology based on microsolid-phase extraction (µSPEed®) followed by gas chromatography–mass spectrometry (GC-MS) has been optimized to quantif...

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Detalles Bibliográficos
Autores: Casado-Hidalgo, Gema, Perestelo, Rosa, Morante-Zarcero, Sonia, Câmara, José S., Sierra, Isabel
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Rey Juan Carlos
Repositorio:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
OAI Identifier:oai:burjcdigital.urjc.es:10115/21229
Acceso en línea:https://hdl.handle.net/10115/21229
Access Level:acceso abierto
Palabra clave:food safety
opium alkaloids
µSPEed
GC-MS
poppy seed tea
transfer
occurrence
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spelling Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS AnalysisCasado-Hidalgo, GemaPerestelo, RosaMorante-Zarcero, SoniaCâmara, José S.Sierra, Isabelfood safetyopium alkaloidsµSPEedGC-MSpoppy seed teatransferoccurrenceIntoxication due to the consumption of poppy seed teas has been reported due to their contamination with opium alkaloids (OAs). In this work, an efficient methodology based on microsolid-phase extraction (µSPEed®) followed by gas chromatography–mass spectrometry (GC-MS) has been optimized to quantify five OAs in poppy seed teas. Nine cartridges (C4, C8, C18, silica, APS, PFAs, PS/DVB-RP, PS/DVB-SCX and PS/DVB-SAX), pH levels, cycles and elution solvents were evaluated. The method was validated and applied to study the transfer of OAs by evaluating water temperatures, infusion times and seed amounts. The highest transfer rates (71% for morphine, 96% for thebaine, and 100% for codeine, noscapine and papaverine) were achieved at 90°C, 5 min, with 4 g. These conditions were used to quantify the OAs in four teas prepared from different seeds. A high amount of morphine (1563 µg/L) was found in one tea, indicating that the seeds had a concentration twice the maximum limit, highlighting the need to warn the population of this dangerous practice.mdpi202320232023info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10115/21229reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlosinstname:Universidad Rey Juan CarlosInglésAttribution 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:burjcdigital.urjc.es:10115/212292026-06-24T12:48:17Z
dc.title.none.fl_str_mv Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS Analysis
title Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS Analysis
spellingShingle Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS Analysis
Casado-Hidalgo, Gema
food safety
opium alkaloids
µSPEed
GC-MS
poppy seed tea
transfer
occurrence
title_short Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS Analysis
title_full Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS Analysis
title_fullStr Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS Analysis
title_full_unstemmed Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS Analysis
title_sort Evaluation of the Transfer and Occurrence of Opium Alkaloids in Poppy Seed Teas Using Preconcentrations with µSPEed® Followed by GC-MS Analysis
dc.creator.none.fl_str_mv Casado-Hidalgo, Gema
Perestelo, Rosa
Morante-Zarcero, Sonia
Câmara, José S.
Sierra, Isabel
author Casado-Hidalgo, Gema
author_facet Casado-Hidalgo, Gema
Perestelo, Rosa
Morante-Zarcero, Sonia
Câmara, José S.
Sierra, Isabel
author_role author
author2 Perestelo, Rosa
Morante-Zarcero, Sonia
Câmara, José S.
Sierra, Isabel
author2_role author
author
author
author
dc.subject.none.fl_str_mv food safety
opium alkaloids
µSPEed
GC-MS
poppy seed tea
transfer
occurrence
topic food safety
opium alkaloids
µSPEed
GC-MS
poppy seed tea
transfer
occurrence
description Intoxication due to the consumption of poppy seed teas has been reported due to their contamination with opium alkaloids (OAs). In this work, an efficient methodology based on microsolid-phase extraction (µSPEed®) followed by gas chromatography–mass spectrometry (GC-MS) has been optimized to quantify five OAs in poppy seed teas. Nine cartridges (C4, C8, C18, silica, APS, PFAs, PS/DVB-RP, PS/DVB-SCX and PS/DVB-SAX), pH levels, cycles and elution solvents were evaluated. The method was validated and applied to study the transfer of OAs by evaluating water temperatures, infusion times and seed amounts. The highest transfer rates (71% for morphine, 96% for thebaine, and 100% for codeine, noscapine and papaverine) were achieved at 90°C, 5 min, with 4 g. These conditions were used to quantify the OAs in four teas prepared from different seeds. A high amount of morphine (1563 µg/L) was found in one tea, indicating that the seeds had a concentration twice the maximum limit, highlighting the need to warn the population of this dangerous practice.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10115/21229
url https://hdl.handle.net/10115/21229
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv mdpi
publisher.none.fl_str_mv mdpi
dc.source.none.fl_str_mv reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
instname:Universidad Rey Juan Carlos
instname_str Universidad Rey Juan Carlos
reponame_str BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
collection BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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